公开(公告)号：US12215123B2

公开(公告)日：2025-02-04

申请号：US18505822

申请日：2023-11-09

Applicant: NANJING TECH UNIVERSITY

Inventor： Hanjie Ying ,  Tao Shen ,  Chenglun Tang ,  Dong Liu ,  Yong Chen ,  Chenjie Zhu ,  Pengpeng Yang ,  Wei Zhuang

IPC: C07H19/20 ,  A61P35/00 ,  C07H19/173

Abstract: A cordycepin-based derived compound with an anti-tumor effect, and a structure of the compound is as shown in formula I; a cordycepin derivative and a pharmaceutical composition thereof provided by the invention have a good anti-tumor proliferation effect; compared with a parent drug, the cordycepin derivative has better affinity to cell membranes, so that a half-life period of in-vivo metabolism of the drug is longer, and in-vivo remaining time of the drug is longer; compared with other nucleoside anti-tumor drugs, the cordycepin derivative and the pharmaceutical composition thereof provided by the invention have wider types and action ranges of tumors, have excellent inhibition effects on a gastric cancer, a pancreatic cancer, a liver cancer, a small cell lung cancer, a colorectal cancer, melanoma, an ovarian cancer and the like, and have lower side effects and better curative effects.

公开(公告)号：US12024732B2

公开(公告)日：2024-07-02

申请号：US18253861

申请日：2021-08-18

Applicant: NANJING TECH UNIVERSITY

Inventor： Chenjie Zhu ,  Hanjie Ying ,  Zhuotao Tan ,  Wei Zhuang ,  Yaping Fu ,  Yaoying Han ,  Ming Li ,  Yong Chen ,  Dong Liu ,  Huanqing Niu ,  Pengpeng Yang

IPC: C12P17/16 ,  C12N9/04 ,  C12P17/12 ,  C12P17/14

CPC classification number: C12P17/16 ,  C12N9/0006 ,  C12P17/12 ,  C12P17/14 ,  C12Y101/01001 ,  C12Y101/01255

Abstract: A method for preparing a nitrogen-containing heterocyclic compound and a derivative thereof by an enzymatic-chemical cascade method, comprising: reacting an alcohol, an amine, an alcohol dehydrogenase, a flavin molecule and a coenzyme in a solvent to obtain the nitrogen-containing heterocyclic compound and the derivative thereof; compared with the prior art, the method is a green and economical enzymatic-chemical cascade method, and is used for synthesizing nitrogen-containing heterocyclic compounds and derivatives thereof; compared with a common toxic chemical catalyst, the alcohol dehydrogenase is selected as a catalyst in the method, which has the characteristics of high substrate specificity, no pollution, high catalytic efficiency, no toxic solvents and simple post-treatment.

公开(公告)号：US11814516B2

公开(公告)日：2023-11-14

申请号：US17305327

申请日：2021-07-05

Applicant: NANJING TECH UNIVERSITY

Inventor： Chenjie Zhu ,  Hanjie Ying ,  Ming Li ,  Pingkai Ouyang ,  Jiannong Shen ,  Xinjian Xu ,  Wei Zhuang ,  Tao Shen

IPC: C08L7/00 ,  B60C1/00

CPC classification number: C08L7/00 ,  B60C1/0041

Abstract: The invention belongs to the field of rubber tire processing, and particularly discloses an application of a lignin in preparing a radial tire, wherein the lignin is capable of completely or partially replacing resorcinol, and meanwhile, the lignin is also capable of completely or partially replacing an anti-aging agent. Compared with the prior art, the resorcinol is replaced or partially replaced by a biomass-derived lignin or a modified lignin in the invention, so that requirements of cost reduction, environmental protection and no toxicity are satisfied. Especially, the lignin modified by demethylation according to the invention is capable of effectively enhancing various properties of rubber.