公开(公告)号：US12024732B2

公开(公告)日：2024-07-02

申请号：US18253861

申请日：2021-08-18

Applicant: NANJING TECH UNIVERSITY

Inventor： Chenjie Zhu ,  Hanjie Ying ,  Zhuotao Tan ,  Wei Zhuang ,  Yaping Fu ,  Yaoying Han ,  Ming Li ,  Yong Chen ,  Dong Liu ,  Huanqing Niu ,  Pengpeng Yang

IPC: C12P17/16 ,  C12N9/04 ,  C12P17/12 ,  C12P17/14

CPC classification number: C12P17/16 ,  C12N9/0006 ,  C12P17/12 ,  C12P17/14 ,  C12Y101/01001 ,  C12Y101/01255

Abstract: A method for preparing a nitrogen-containing heterocyclic compound and a derivative thereof by an enzymatic-chemical cascade method, comprising: reacting an alcohol, an amine, an alcohol dehydrogenase, a flavin molecule and a coenzyme in a solvent to obtain the nitrogen-containing heterocyclic compound and the derivative thereof; compared with the prior art, the method is a green and economical enzymatic-chemical cascade method, and is used for synthesizing nitrogen-containing heterocyclic compounds and derivatives thereof; compared with a common toxic chemical catalyst, the alcohol dehydrogenase is selected as a catalyst in the method, which has the characteristics of high substrate specificity, no pollution, high catalytic efficiency, no toxic solvents and simple post-treatment.