Portable controlled micro-environment device for modular bio-processing

    公开(公告)号:US11285471B2

    公开(公告)日:2022-03-29

    申请号:US15993481

    申请日:2018-05-30

    Applicant: Nextern, Inc.

    Abstract: Apparatus and associated methods relate to an adaptable microenvironment for cellular and biological processing in a traceable, transportable unit. In an illustrative example, an apparatus consists of one or more portable cell tissue containment modules that may be removably interconnected to perform a processing step and/or transfer the stored medium to another module. Associated apparatus and methods are proposed to ensure non-contaminating mechanical or fluid communication between a plurality of modules or between a module and peripheral equipment, to limit process errors such as steps performed out of order, and to intrinsically manage identification of tissue samples with accompanying process data in a manner that decreases risk of mislabeling or otherwise mishandling a sample at all stages of the production and treatment process.

    Canted off-axis driver for quiet pneumatic pumping

    公开(公告)号:US09920753B2

    公开(公告)日:2018-03-20

    申请号:US14796756

    申请日:2015-07-10

    Applicant: Nextern, Inc.

    CPC classification number: F04B43/04 F04B43/021

    Abstract: Apparatus and associated methods relate to nutating a piston drive linkage oriented around a longitudinal axis in response to the rotation of a drive shaft about a drive axis of rotation, said longitudinal axis being offset and canted with respect to said drive axis of rotation. In an illustrative example, the piston drive linkage may be formed as an umbrella shape with multiple arm members extending radially from the longitudinal axis. The distal ends of each of the radial arm members may attach to a stationary piston crank. The nutating motion of the piston drive linkage may impart a substantially linear motion profile substantially parallel to the drive axis of rotation. A shaft extending along the longitudinal axis from the piston linkage may advantageously freely insert into and rotate within a receptacle of a spinner body being rotated around the drive axis of rotation.

    ROBOTICALLY AUGMENTED CATHETER MANIPULATION HANDLE

    公开(公告)号:US20200254219A1

    公开(公告)日:2020-08-13

    申请号:US16861633

    申请日:2020-04-29

    Applicant: Nextern, Inc.

    Abstract: Apparatus and associated methods relate to a catheter manipulation handle with user interface controls for steering a catheter in situ while providing an augmented (e.g., motorized, powered and tunable precision steering, and perforation safeguards) control and feedback user experience. In an illustrative example, the catheter manipulation handle may provide motor assisted operation to automatically rotate and/or deflect a distal tip of the catheter to steer and guide the distal tip to a target location in the patient's vasculature system. The augmented feedback may include, for example, haptic feedback via the handle. Haptic, audible, and/or visual feedback via the handle may indicate, for example, proximity or engagement of the distal tip with sensitive tissue. In some examples, the handle's augmented operation may advantageously amplify feedback signals to enhance the user's perception of the patient's safety with respect to the safe passage of the distal tip through the patient's vasculature.

    WEARABLE ACTIVE-COMPRESSION THERAPY AND TREATMENT

    公开(公告)号:US20200060926A1

    公开(公告)日:2020-02-27

    申请号:US16654459

    申请日:2019-10-16

    Applicant: Nextern, Inc.

    Abstract: Apparatus and associated methods relate to a wearable compression therapy system for ambulatory therapy, the system including a wearable garment having one or more inflatable chambers, and a pneumatic engine locally coupled to the garment to provide control and inflation of the one or more inflatable chambers. In an illustrative embodiment, the pneumatic engine may control a pump and one or more valves to inflate the inflatable chambers. The valves and pump may be coordinated according to a pre-programmed profile. In some embodiments, the pneumatic engine may have a wireless interface configured to receive control signals from a remote mobile device untethered from the garment. The pneumatic engine may send to the remote mobile device signals indicative of sensed conditions of the compression therapy system. In some embodiments, the pneumatic engine may include a power source that advantageously permits the user to be untethered from a source of power.

    Responsive whole patient care compression therapy and treatment system

    公开(公告)号:US10285898B2

    公开(公告)日:2019-05-14

    申请号:US14965763

    申请日:2015-12-10

    Applicant: Nextern Inc.

    Abstract: Apparatus and methods relate to a pneumatic compression therapy device configured to suggest content to the patient based on a determined disease state, the content pertaining to suggested changes in lifestyle based on a standard of care. In an illustrative embodiment, the suggested changes may include modifications to treatment location, treatment time, diet, eating habits, or sleeping schedule. Various examples may further sample the patient's health and automatically adjust a treatment parameter within a predetermined parameter range based on a history of measured parameters, such as limb volume, for example. In coordination with the therapeutic treatment, the therapy device may deliver suggested content to guide the patient to make more healthful lifestyle choices to reduce recovery time and improve patient health outcomes.

    Pneumatic distribution system using shared pump plenum

    公开(公告)号:US10087925B2

    公开(公告)日:2018-10-02

    申请号:US14946438

    申请日:2015-11-19

    Applicant: Nextern Inc.

    Abstract: Apparatus and associated methods relate to a pneumatic distribution system having pneumatic pump that exhausts into a common plenum that is in fluid communication with a plurality of flow controllers. In an illustrative embodiment, a system controller may coordinate the operation of the one or more pneumatic pumps and the plurality of flow controllers to provide air pressure control to a system of pneumatic chambers. In some embodiments, one of the plurality of flow controllers may be configured to provide fluid communication with an ambient atmosphere so as to permit a fluid path from a pneumatic chamber connected to another flow controller to the ambient atmosphere via both flow controllers and the common plenum. In an exemplary embodiment, the system controller may advantageously control the air pressures in a plurality of pneumatic chambers independently of one another using coordinated control of the pump and flow controllers.

    CANTED OFF-AXIS DRIVER FOR QUIET PNEUMATIC PUMPING
    7.
    发明申请
    CANTED OFF-AXIS DRIVER FOR QUIET PNEUMATIC PUMPING 有权
    可选择的离轴驱动器用于定位气动抽吸

    公开(公告)号:US20160047365A1

    公开(公告)日:2016-02-18

    申请号:US14796756

    申请日:2015-07-10

    Applicant: Nextern,Inc

    CPC classification number: F04B43/04 F04B43/021

    Abstract: Apparatus and associated methods relate to nutating a piston drive linkage oriented around a longitudinal axis in response to the rotation of a drive shaft about a drive axis of rotation, said longitudinal axis being offset and canted with respect to said drive axis of rotation. In an illustrative example, the piston drive linkage may be formed as an umbrella shape with multiple arm members extending radially from the longitudinal axis. The distal ends of each of the radial arm members may attach to a stationary piston crank. The nutating motion of the piston drive linkage may impart a substantially linear motion profile substantially parallel to the drive axis of rotation. A shaft extending along the longitudinal axis from the piston linkage may advantageously freely insert into and rotate within a receptacle of a spinner body being rotated around the drive axis of rotation.

    Abstract translation: 装置和相关方法涉及响应于围绕驱动旋转轴线的驱动轴的旋转而围绕纵向轴线定向的活塞驱动联动装置,所述纵向轴线相对于所述驱动旋转轴线偏移和倾斜。 在说明性的示例中,活塞驱动联动装置可以形成为伞形,其中多个臂构件从纵向轴线径向延伸。 每个径向臂构件的远端可以附接到静止的活塞曲柄。 活塞驱动联动装置的章动运动可以实质上基本上平行于驱动旋转轴线的运动曲线。 沿着纵向轴线从活塞连接件延伸的轴可以有利地自由地插入并旋转在围绕驱动旋转轴线旋转的旋转体的容器内。

    Robotically augmented catheter manipulation handle

    公开(公告)号:US11717644B2

    公开(公告)日:2023-08-08

    申请号:US16861633

    申请日:2020-04-29

    Applicant: Nextern, Inc.

    Abstract: Apparatus and associated methods relate to a catheter manipulation handle with user interface controls for steering a catheter in situ while providing an augmented (e.g., motorized, powered and tunable precision steering, and perforation safeguards) control and feedback user experience. In an illustrative example, the catheter manipulation handle may provide motor assisted operation to automatically rotate and/or deflect a distal tip of the catheter to steer and guide the distal tip to a target location in the patient's vasculature system. The augmented feedback may include, for example, haptic feedback via the handle. Haptic, audible, and/or visual feedback via the handle may indicate, for example, proximity or engagement of the distal tip with sensitive tissue. In some examples, the handle's augmented operation may advantageously amplify feedback signals to enhance the user's perception of the patient's safety with respect to the safe passage of the distal tip through the patient's vasculature.

    METHOD AND SYSTEM RELATED TO COLLECTION AND CORRELATION OF DATA FROM MULTIPLE SOURCES

    公开(公告)号:US20200037878A1

    公开(公告)日:2020-02-06

    申请号:US16530548

    申请日:2019-08-02

    Applicant: Nextern, Inc.

    Abstract: Apparatus and methods are directed to virtually verifying authenticity of medical information transmitted from at least one unvalidated communication device associated with a patient being monitored by at least on validated medical device. In an illustrative example, medical information related to patient data may be transmitted through a network for storage in a central database from one or more validated medical devices and one or more unvalidated personal communication devices. The transmitted information may include unique identifiers that enables the patient data to be verified and collated across the validated and unvalidated devices and assigned to a specific data record for a given patient or group of patients.

    SOLENOID OPERATED VALVE WITH FLUX DENSITY CONCENTRATION RING AND MOLDED-IN VALVE SEAT

    公开(公告)号:US20190219188A1

    公开(公告)日:2019-07-18

    申请号:US15873760

    申请日:2018-01-17

    Applicant: Nextern, Inc.

    CPC classification number: F16K31/0631 F16K1/465 F16K3/0254 F16K31/0606

    Abstract: Apparatus and associated methods relate to a solenoid assisted valve including a split collar and a precision sealing valve seat surface with tight dimensional tolerances and substantial performance repeatability. In an illustrative example, the split collar may concentrically mate around a cylindrical bobbin. In some examples, the split collar may include ferromagnetic material alone or in combination with various thermoplastic materials. The placement of the split collar may be adjusted by manufacturing to fine tune placement of a magnetic pole and to customize valve performance, for example. The valve seat may include, for example, an orifice sealed with an elastic stopper. The valve seat may be configured, for example, with specific ratiometric dimensional relationships and flatness specifications. Various solenoid valves may allow manufacturers to tune the location of a solenoid generated magnetic pole, for example, to tailor the valve plunger performance for a wide variety of applications.

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