公开(公告)号：US20190292549A1

公开(公告)日：2019-09-26

申请号：US16253547

申请日：2019-01-22

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Ke ZHANG ,  Dali Wang

IPC: C12N15/113 ,  C12N15/87 ,  A61K47/10 ,  A61K47/69 ,  A61K47/56

Abstract: Disclosed are bottlebrush poly(ethylene glycol) (PEG) polymer-RNA conjugates (pacRNA) having a plurality of PEG side chains attached to a polymer backbone, and one or more RNA oligonucleotides attached to the polymer backbone via a cleavable linkage. The pacRNAs offer potential useful novel RNA-based therapeutics.

公开(公告)号：US20250135013A1

公开(公告)日：2025-05-01

申请号：US18683235

申请日：2022-08-19

Applicant: Northeastern University

Inventor： Ke Zhang ,  Dali Wang

IPC: A61K47/60 ,  A61P35/00 ,  C12N15/113

Abstract: Provided herein are, in various embodiments, methods and compositions comprising polyethylene glycol (PEG)-conjugated oligonucleotides (e.g., anti-sense oligonucleotides) for treatment of cancer. In certain embodiments, the disclosure provides for methods and compositions for enhancing efficacy of anti-sense oligonucleotides. In still further embodiments, the disclosure provides methods and compositions for treatment of non-small cell lung cancer.