公开(公告)号：US20250163418A1

公开(公告)日：2025-05-22

申请号：US18940823

申请日：2024-11-07

Applicant: Northeastern University

Inventor： Ke Zhang

IPC: C12N15/113 ,  A61P21/00

Abstract: Provided herein are, in various embodiments, methods and compositions for treating muscular dystrophy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising a bottlebrush polymer-oligonucleotide conjugate. Also provided herein are methods of making bottlebrush polymer-oligonucleotide conjugates.

公开(公告)号：US20250049935A1

公开(公告)日：2025-02-13

申请号：US18720511

申请日：2022-12-16

Applicant: Northeastern University

Inventor： Ke Zhang ,  Yuyan Wang

IPC: A61K47/60 ,  A61K45/06 ,  C12N15/115

Abstract: Provided herein are, in various embodiments, are bottlebrush polymer-oligonucleotides conjugates. In certain embodiments, the conjugates are potent in vivo, have improved biopharmaceutical properties, enhanced transfection efficiency, and/or an unconventional biodistribution profile. Also provided herein are pharmaceutical compositions, methods of treatment, and methods of making bottlebrush polymer-oligonucleotide conjugates.

公开(公告)号：US10590414B2

公开(公告)日：2020-03-17

申请号：US15750360

申请日：2016-08-04

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Ke Zhang ,  Xueguang Lu

IPC: C12N15/113 ,  A61K49/00 ,  C12Q1/6886

Abstract: The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a non-cationic, sterically congested brush polymer and the use of such polymer-oligonucleotide conjugates in antisense gene regulation and as diagnostic agents.

公开(公告)号：US20250135013A1

公开(公告)日：2025-05-01

申请号：US18683235

申请日：2022-08-19

Applicant: Northeastern University

Inventor： Ke Zhang ,  Dali Wang

IPC: A61K47/60 ,  A61P35/00 ,  C12N15/113

Abstract: Provided herein are, in various embodiments, methods and compositions comprising polyethylene glycol (PEG)-conjugated oligonucleotides (e.g., anti-sense oligonucleotides) for treatment of cancer. In certain embodiments, the disclosure provides for methods and compositions for enhancing efficacy of anti-sense oligonucleotides. In still further embodiments, the disclosure provides methods and compositions for treatment of non-small cell lung cancer.

公开(公告)号：US11104901B2

公开(公告)日：2021-08-31

申请号：US16796034

申请日：2020-02-20

Applicant: NORTHEASTERN UNIVERSITY

Inventor： Ke Zhang ,  Xueguang Lu

IPC: C12N15/113 ,  A61K49/00 ,  C12Q1/6886 ,  G06F9/48 ,  G06F9/50

Abstract: The disclosed subject matter relates to brush polymer-oligonucleotide conjugates comprising oligonucleotides covalently attached to the backbone of a non-cationic, sterically congested brush polymer and the use of such polymer-oligonucleotide conjugates in antisense gene regulation and as diagnostic agents.