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公开(公告)号：US09637582B2
公开(公告)日：2017-05-02
申请号：US14859486
申请日：2015-09-21
Applicant: Novartis AG
Inventor： Frank Chang , Jinyu Huang , Venkat Shankar
IPC: C08L83/04 , C08F230/08 , C08G77/42 , C08G77/442 , G02C7/04 , G02B1/04 , C08J3/03 , C08J3/075 , C08F220/00 , C08J3/28 , C08F290/06 , C08G77/20 , C08G77/38 , C08G77/445 , C08G77/48 , C08L51/08 , C08L83/06 , C08L83/10 , C08L83/14
CPC classification number: G02B1/043 , B29D11/00134 , B29D11/00192 , B29K2083/00 , B29K2105/0061 , C08F220/00 , C08F220/58 , C08F230/08 , C08F290/068 , C08F2220/585 , C08G77/20 , C08G77/26 , C08G77/28 , C08G77/38 , C08G77/42 , C08G77/442 , C08G77/445 , C08G77/48 , C08G2210/00 , C08J3/03 , C08J3/075 , C08J3/28 , C08L51/085 , C08L83/06 , C08L83/10 , C08L83/14 , G02C7/04 , C08L83/04 , C08L101/14
Abstract: The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.
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公开(公告)号：US20160090432A1
公开(公告)日：2016-03-31
申请号：US14859486
申请日：2015-09-21
Applicant: Novartis AG
Inventor： Frank Chang , Jinyu Huang , Venkat Shankar
IPC: C08F230/08 , G02B1/04
CPC classification number: G02B1/043 , B29D11/00134 , B29D11/00192 , B29K2083/00 , B29K2105/0061 , C08F220/00 , C08F220/58 , C08F230/08 , C08F290/068 , C08F2220/585 , C08G77/20 , C08G77/26 , C08G77/28 , C08G77/38 , C08G77/42 , C08G77/442 , C08G77/445 , C08G77/48 , C08G2210/00 , C08J3/03 , C08J3/075 , C08J3/28 , C08L51/085 , C08L83/06 , C08L83/10 , C08L83/14 , G02C7/04 , C08L83/04 , C08L101/14
Abstract: The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.
Abstract translation: 本发明提供了一种光聚合性两亲性聚硅氧烷，其包含聚硅氧烷聚合物链，其包含聚硅氧烷链段，该聚硅氧烷链段包含至少一个硅氧烷单元，该硅氧烷单元具有与硅氧烷单元的硅氧烷原子连接的低分子量亲水性聚合物链和各自的（甲基）丙烯酰胺基 共价键合到聚硅氧烷聚合物链的一个端部和/或每个与一个硅氧烷原子连接的低分子量亲水聚合物链之一的末端。 本发明还涉及聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜，其包含衍生自本发明的可光化聚合的两亲聚硅氧烷的重复单元。 此外，本发明提供了使用包含本发明的可自由基聚合的两亲性聚硅氧烷和/或本发明的可光化交联的含硅氧烷预聚物的水性透镜形成剂制备硅酮水凝胶隐形眼镜的方法。
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公开(公告)号：US10598825B2
公开(公告)日：2020-03-24
申请号：US16398607
申请日：2019-04-30
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Yasuo Matsuzawa , Venkat Shankar
IPC: G02B1/04 , A61L27/18 , A61L27/34 , A61F2/14 , C08L83/04 , A61F2/16 , A61F9/007 , A61L12/04 , C08G77/12 , C08G77/20
Abstract: The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.
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公开(公告)号：US09921340B2
公开(公告)日：2018-03-20
申请号：US14883142
申请日：2015-10-14
Applicant: Novartis AG
Inventor： Jinyu Huang , Frank Chang , Robert Scott , Arturo Norberto Medina , Venkat Shankar , Selma Kuyu , Dawn Alison Smith , Daqing Wu
CPC classification number: G02B1/043 , C08G77/20 , C08G77/42 , C08G77/442 , C08J3/075 , C08J2343/04 , C08J2383/08 , C08L83/10 , C08L101/14 , C08L83/04
Abstract: The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.
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公开(公告)号：US20150369962A1
公开(公告)日：2015-12-24
申请号：US14840169
申请日：2015-08-31
Applicant: Novartis AG
Inventor： Frank Chang , Venkat Shankar
CPC classification number: G02B1/043 , B29C35/08 , B29C39/006 , B29C39/026 , B29K2083/00 , B29L2011/0041 , C08G18/61 , C08G18/755 , C08G73/0233 , C08G73/0246 , C08G77/452 , G02C7/049 , C08L83/04 , C08L101/14 , C08G18/10 , C08G18/6453 , C08G18/6415 , C08G18/2825 , C08G18/4833
Abstract: The invention provide a class of actinically-crosslinkable amphiphilic prepolymers which comprise at least one polysiloxane segment, at least one polyoxazoline segment, and two terminal ene groups. The present invention is also related to a medical device comprising a silicone hydrogel material obtained from step-growth polymerization of a polymerizable material comprising a prepolymer of the invention and to a method for producing contact lenses from a prepolymer of the invention.
Abstract translation: 本发明提供一类包含至少一个聚硅氧烷链段，至少一个聚恶唑啉链段和两个末端烯基的可光化交联的两亲性预聚物。 本发明还涉及包含由包含本发明的预聚物的可聚合材料的步进生长聚合获得的硅酮水凝胶材料和由本发明的预聚物制备隐形眼镜的方法的医疗装置。
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Patent Agency Ranking
6.发明授权Chain-extended polysiloxane crosslinkers with dangling hydrophilic polymer chains 有权具有悬浮亲水性聚合物链的链延长聚硅氧烷交联剂公开(公告)号：US09052440B2
公开(公告)日：2015-06-09
申请号：US14453021
申请日：2014-08-06
Applicant: Novartis AG
Inventor： Selma Kuyu , Dawn Alison Smith , Jinyu Huang , Frank Chang , Robert Scott , Arturo Norberto Medina , Venkat Shankar
CPC classification number: G02B1/043 , A61K47/34 , C08G77/20 , C08G77/38 , C08G77/42 , C08G77/442 , C08G77/46 , C08L83/10 , G02B2207/109 , C08L83/12 , C08L83/14
Abstract: The invention provide a class of linear chain-extended polysiloxane crosslinkers which comprises two terminal ethylenically unsaturated groups, at least two polysiloxane segments, and dangling hydrophilic polymer chains each covalently attached to a divalent organic radical separating each pair of adjacent polysiloxane segments. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.
Abstract translation: 本发明提供一类线性延伸的聚硅氧烷交联剂，其包含两个末端烯键式不饱和基团，至少两个聚硅氧烷链段和悬浮的亲水性聚合物链，每个共价连接到分隔每对相邻聚硅氧烷链段的二价有机基团。 本发明还涉及包含衍生自本发明的链延长聚硅氧烷交联剂的交联单元和包含这种聚合物的眼用透镜的聚合物。
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公开(公告)号：US10100219B2
公开(公告)日：2018-10-16
申请号：US15216125
申请日：2016-07-21
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Yongxing Qiu , John Dallas Pruitt , Chung-Yuan Chiang , Venkat Shankar , Robert Scott , Yash Kapoor
IPC: C09D133/24 , C07D205/04 , C08F220/56 , B29D11/00 , C08F224/00 , C09D137/00 , C08F283/12 , C09D151/08 , C08F220/54 , C09D133/26 , C09D139/04 , C08F20/00 , C08F26/00
Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.
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公开(公告)号：US09810812B2
公开(公告)日：2017-11-07
申请号：US15249587
申请日：2016-08-29
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Yasuo Matsuzawa , Venkat Shankar
CPC classification number: G02B1/043 , B29D11/00048 , B29D11/00067 , B29D11/00125 , C08J7/123 , C08J2383/08 , C08J2433/02 , C08J2471/00 , C08J2477/00
Abstract: The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.
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9.发明申请公开(公告)号：US20170068018A1
公开(公告)日：2017-03-09
申请号：US15249577
申请日：2016-08-29
Applicant: Novartis AG
Inventor： Xinming Qian , Frank Chang , Yasuo Matsuzawa , Venkat Shankar
CPC classification number: G02B1/043 , A61F2/14 , A61F2/1451 , A61F2/16 , A61F9/00781 , A61F2210/0061 , A61L12/04 , A61L27/18 , A61L27/34 , A61L2400/10 , A61L2400/18 , A61L2430/16 , C08L83/04
Abstract: The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.
Abstract translation: 本发明涉及一种医疗装置，其包括由交联的硅氧烷材料制成的芯材料和热力学稳定的水凝胶涂层。 本发明还涉及一种用于制造这种医疗装置，特别是软性隐形眼镜的方法。
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公开(公告)号：US20160326395A1
公开(公告)日：2016-11-10
申请号：US15216125
申请日：2016-07-21
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Yongxing Qiu , John Dallas Pruitt , Chung-Yuan Chiang , Venkat Shankar , Robert Scott , Yash Kapoor
IPC: C09D133/24 , C07D205/04 , C08F220/56 , B29D11/00 , C08F224/00 , C09D137/00 , C08F283/12 , C09D151/08 , C08F220/54 , C09D133/26
CPC classification number: C09D133/24 , B29D11/00865 , C07D205/04 , C08F20/00 , C08F26/00 , C08F220/54 , C08F220/56 , C08F224/00 , C08F283/124 , C08F2500/26 , C09D133/26 , C09D137/00 , C09D139/04 , C09D151/085
Abstract: The invention is related to azetidinium-containing copolymers and vinylic monomers and their uses in formation of non-silicone hydrogel coatings on silicone hydrogel contact lenses.
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