公开(公告)号：US20150338375A1

公开(公告)日：2015-11-26

申请号：US14818404

申请日：2015-08-05

Applicant: Ohio University

Inventor： HAO CHEN ,  Zhixin Miao

IPC: G01N27/68 ,  H01J49/16 ,  G01N33/68 ,  H01J49/04

CPC classification number: G01N27/68 ,  G01N1/00 ,  G01N33/48707 ,  G01N33/6848 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/145 ,  H01J49/165

Abstract: A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length. An ambient ionization source (10) is directed toward a selected variable location along the continuous liquid jet (50) to desorb at least a portion of the continuous liquid jet (50). A mass analyzer (30) analyzes a mass-to-charge ratio of an ionized sample that is within the desorbed portion of the continuous liquid jet (50). The acquired mass spectra reflect the reaction progress in different reaction times and, therefore, may be used to derive the reaction rate.

Abstract translation: 描述了用于快速反应的动力学研究的微秒时间分辨质谱装置和使用解吸电喷雾电离的方法（10）。 该装置包括液体喷射发生器（64），其构造成发射具有长度的连续液体射流（50）。 环境电离源（10）沿着连续液体射流（50）指向选定的可变位置以解吸至少一部分连续液体射流（50）。 质量分析器（30）分析在连续液体射流（50）的解吸附部分内的电离样品的质荷比。 所获得的质谱反映了不同反应时间的反应进程，因此可用于得到反应速率。

公开(公告)号：US09651521B2

公开(公告)日：2017-05-16

申请号：US14818404

申请日：2015-08-05

Applicant: Ohio University

Inventor： Hao Chen ,  Zhixin Miao

IPC: G01N27/68 ,  H01J49/16 ,  H01J49/04 ,  G01N33/68 ,  G01N1/00 ,  H01J49/14 ,  G01N33/487

CPC classification number: G01N27/68 ,  G01N1/00 ,  G01N33/48707 ,  G01N33/6848 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/145 ,  H01J49/165

Abstract: A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length. An ambient ionization source (10) is directed toward a selected variable location along the continuous liquid jet (50) to desorb at least a portion of the continuous liquid jet (50). A mass analyzer (30) analyzes a mass-to-charge ratio of an ionized sample that is within the desorbed portion of the continuous liquid jet (50). The acquired mass spectra reflect the reaction progress in different reaction times and, therefore, may be used to derive the reaction rate.