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公开(公告)号：US09651521B2
公开(公告)日：2017-05-16
申请号：US14818404
申请日：2015-08-05
Applicant: Ohio University
Inventor： Hao Chen , Zhixin Miao
CPC classification number: G01N27/68 , G01N1/00 , G01N33/48707 , G01N33/6848 , H01J49/0445 , H01J49/045 , H01J49/145 , H01J49/165
Abstract: A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization (10) was described for the kinetic study of fast reactions. The device includes a liquid jet generator (64) that is configured to emit a continuous liquid jet (50) having a length. An ambient ionization source (10) is directed toward a selected variable location along the continuous liquid jet (50) to desorb at least a portion of the continuous liquid jet (50). A mass analyzer (30) analyzes a mass-to-charge ratio of an ionized sample that is within the desorbed portion of the continuous liquid jet (50). The acquired mass spectra reflect the reaction progress in different reaction times and, therefore, may be used to derive the reaction rate.
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公开(公告)号：US09400267B2
公开(公告)日：2016-07-26
申请号：US14889625
申请日：2013-10-02
Applicant: Ohio University
IPC: G01N30/72
CPC classification number: G01N30/724 , G01N30/7233 , G01N2030/8429 , H01J49/145
Abstract: An apparatus (10) for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (16), which defines a flow passage (18) and is configured to supply the liquid sample. The fluid conduit (16) has an outer surface and a micro-hole (30) through the outer surface into the flow passage (18). The apparatus (10) also includes an ambient ionizer (40) configured to generate and direct a charged solvent (44) toward the micro-hole (30) at the outer surface for ionizing a portion of the liquid sample (32) that emerges out of the micro-hole (30). The apparatus (10) further includes a mass spectrometer (60) having a sample entrance (62) adjacent the micro-hole (30) configured to analyze an ionized portion of the liquid sample (54).
Abstract translation: 用于将液相色谱与质谱耦合并用于分离和分析液体样品的装置（10）包括限定流路（18）并被配置为供应液体样品的流体导管（16）。 流体管道（16）具有外表面和穿过外表面进入流动通道（18）的微孔（30）。 设备（10）还包括环境离子发生器（40），其被配置为在外表面处向带电溶剂（44）产生并引导微孔（30），用于离开出现的液体样品（32）的一部分 的微孔（30）。 装置（10）还包括质谱仪（60），其具有邻近微孔（30）的样品入口（62），该样品入口构造成分析液体样品（54）的离子化部分。
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公开(公告)号：US09977028B2
公开(公告)日：2018-05-22
申请号：US14441385
申请日：2013-11-07
Applicant: Ohio University
Inventor： Hao Chen , Ning Pan , Pengyuan Liu
CPC classification number: G01N33/6848 , C12Q1/6806 , G01N33/66 , G01N33/6842 , H01J49/0031 , H01J49/165 , C12Q2565/627 , C12Q1/06
Abstract: A mass spectrometry-based method for analyzing an acidic organic target compound includes directing a charged solvent (44) toward a pre-acidified sample (12) comprising the target compound, to thereby ionize the pre-acidified sample (12). The method further includes directing the ionized pre-acidified sample (54) to a mass spectrometer (18), the mass spectrometer (18) being configured to identify and quantify the target compound.
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公开(公告)号：US11360058B2
公开(公告)日：2022-06-14
申请号：US16341622
申请日：2017-10-25
Applicant: Ohio University
Inventor： Hao Chen
Abstract: A method of quantifying a target compound includes applying an oxidation/reduction potential to an electrochemical cell (14); measuring an electrochemical current during the application of the oxidation/reduction potential; and ionizing and directing the target compound before and after the application of the oxidation/reduction potential to a mass spectrometer (16) that measures a target compound ion intensity. The method further includes determining a target compound ion intensity change due to the application of the oxidation/reduction potential and determining a total amount of the target compound in the sample using the measured electrochemical current and the target compound ion intensity change. Determining the target compound ion intensity change may comprise either comparing the target compound ion intensity before and after the electrolysis relative to a reference peak or comparing the integrated peak area of a target compound ion in an extracted ion chromatogram before and after the electrolysis.
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Patent Agency Ranking
公开(公告)号：US20210333248A1
公开(公告)日：2021-10-28
申请号：US16341622
申请日：2017-10-25
Applicant: Ohio University
Inventor： Hao Chen
Abstract: A method of quantifying a target compound includes applying an oxidation/reduction potential to an electrochemical cell (14); measuring an electrochemical current during the application of the oxidation/reduction potential; and ionizing and directing the target compound before and after the application of the oxidation/reduction potential to a mass spectrometer (16) that measures a target compound ion intensity. The method further includes determining a target compound ion intensity change due to the application of the oxidation/reduction potential and determining a total amount of the target compound in the sample using the measured electrochemical current and the target compound ion intensity change. Determining the target compound ion intensity change may comprise either comparing the target compound ion intensity before and after the electrolysis relative to a reference peak or comparing the integrated peak area of a target compound ion in an extracted ion chromatogram before and after the electrolysis.
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公开(公告)号：US20160123936A1
公开(公告)日：2016-05-05
申请号：US14889625
申请日：2013-10-02
Applicant: OHIO UNIVERSITY
IPC: G01N30/72
CPC classification number: G01N30/724 , G01N30/7233 , G01N2030/8429 , H01J49/145
Abstract: An apparatus (10) for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (16), which defines a flow passage (18) and is configured to supply the liquid sample. The fluid conduit (16) has an outer surface and a micro-hole (30) through the outer surface into the flow passage (18). The apparatus (10) also includes an ambient ionizer (40) configured to generate and direct a charged solvent (44) toward the micro-hole (30) at the outer surface for ionizing a portion of the liquid sample (32) that emerges out of the micro-hole (30). The apparatus (10) further includes a mass spectrometer (60) having a sample entrance (62) adjacent the micro-hole (30) configured to analyze an ionized portion of the liquid sample (54).
Abstract translation: 用于将液相色谱与质谱耦合并用于分离和分析液体样品的装置（10）包括限定流路（18）并被配置为供应液体样品的流体导管（16）。 流体管道（16）具有外表面和穿过外表面进入流动通道（18）的微孔（30）。 设备（10）还包括环境离子发生器（40），其被配置为在外表面处向带电溶剂（44）产生并引导微孔（30），用于离开出现的液体样品（32）的一部分 的微孔（30）。 装置（10）还包括质谱仪（60），其具有邻近微孔（30）的样品入口（62），该样品入口构造成分析液体样品（54）的离子化部分。
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公开(公告)号：US10290479B2
公开(公告)日：2019-05-14
申请号：US14441245
申请日：2013-11-07
Applicant: Ohio University
Inventor： Hao Chen , Ning Pan , Howard Dewald
IPC: H01J49/00 , H01M8/0444 , H01M8/10 , H01M8/0662 , H01M8/1011 , H01J49/04 , H01M8/1018
Abstract: A mass spectrometry-based method of directly online detecting fuel cell reaction products includes passing a reactant sample (16) through a fuel cell (12) to form reaction products that exit the fuel cell (12) in an output stream (26). The method also includes adding a derivatizing reagent (32) to the output stream (28) to form a derivatized output stream (34), wherein the derivatizing reagent (32) reacts with a potential reaction product to thereby form a derivatized reaction product if the potential reaction product is present. The method further includes directing a charged solvent (44) toward the derivatized output stream (34) to thereby ionize the derivatized output stream (34) and directing the ionized, derivatized output stream (54) to a mass spectrometer (14), the mass spectrometer (14) being configured to detect the derivatized reaction product.
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8.发明申请Online Monitoring of Fuel Cell Reactions by Desorption Electrospray Mass Spectrometry 审中-公开通过解吸电喷雾质谱在线监测燃料电池反应公开(公告)号：US20150288013A1
公开(公告)日：2015-10-08
申请号：US14441245
申请日：2013-11-07
Applicant: OHIO UNIVERSITY
Inventor： Hao Chen , Ning Pan , Howard Dewald
CPC classification number: H01J49/0031 , H01J49/04 , H01M8/04462 , H01M8/0447 , H01M8/0662 , H01M8/10 , H01M8/1011 , H01M2008/1095 , H01M2300/0082 , Y02E60/523
Abstract: A mass spectrometry-based method of directly online detecting fuel cell reaction products includes passing a reactant sample (16) through a fuel cell (12) to form reaction products that exit the fuel cell (12) in an output stream (26). The method also includes adding a derivatizing reagent (32) to the output stream (28) to form a derivatized output stream (34), wherein the derivatizing reagent (32) reacts with a potential reaction product to thereby form a derivatized reaction product if the potential reaction product is present. The method further includes directing a charged solvent (44) toward the derivatized output stream (34) to thereby ionize the derivatized output stream (34) and directing the ionized, derivatized output stream (54) to a mass spectrometer (14), the mass spectrometer (14) being configured to detect the derivatized reaction product.
Abstract translation: 直接在线检测燃料电池反应产物的基于质谱的方法包括使反应物样品（16）通过燃料电池（12），以形成在输出流（26）中离开燃料电池（12）的反应产物。 该方法还包括向输出流（28）加入衍生化试剂（32）以形成衍生化的输出流（34），其中衍生试剂（32）与潜在的反应产物反应，从而形成衍生化反应产物，如果 存在潜在的反应产物。 该方法还包括将带电溶剂（44）引向衍生的输出流（34），从而使衍生的输出流（34）电离并将离子化的衍生的输出流（54）引导到质谱仪（14），质量 光谱仪（14）被配置为检测衍生的反应产物。
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9.发明申请Ionization of Chemicals in Mixture at Low pH by Ambient Ionization/Mass Spectrometry 有权通过环境电离/质谱法在低pH下混合物中化学物质的离子化公开(公告)号：US20150293116A1
公开(公告)日：2015-10-15
申请号：US14441385
申请日：2013-11-07
Applicant: OHIO UNIVERSITY
Inventor： Hao Chen , Ning Pan , Pengyuan Liu
IPC: G01N33/68
CPC classification number: G01N33/6848 , C12Q1/6806 , G01N33/66 , G01N33/6842 , H01J49/0031 , H01J49/165 , C12Q2565/627 , C12Q1/06
Abstract: A mass spectrometry-based method for analyzing an acidic organic target compound includes directing a charged solvent (44) toward a pre-acidified sample (12) comprising the target compound, to thereby ionize the pre-acidified sample (12). The method further includes directing the ionized pre-acidified sample (54) to a mass spectrometer (18), the mass spectrometer (18) being configured to identify and quantify the target compound.
Abstract translation: 用于分析酸性有机靶化合物的基于质谱法的方法包括将带电溶剂（44）引导到包含目标化合物的预酸化样品（12），从而使预酸化样品（12）电离。 该方法还包括将离子化的预酸化样品（54）引导到质谱仪（18），质谱仪（18）被配置为鉴定和定量目标化合物。
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