Thermochromic sensing for nanocalorimetry

    公开(公告)号:US11543303B2

    公开(公告)日:2023-01-03

    申请号:US16801479

    申请日:2020-02-26

    Abstract: A nanocalorimeter device includes a substrate having test cells, each test cell comprising a sample location. Each sample location includes a reaction surface suitable for an enthalpic reaction of constituents of liquid droplets, droplet movement and configured to merge the droplets, and a layer of thermochromic material thermally coupled to the reaction surface. The thermochromic material is configured to exhibit a spectral shift in light emanating from the thermochromic material in response to a change in temperature of the merged droplets.

    OBTAINING SPECTRAL INFORMATION FROM A MOVING OBJECT
    8.
    发明申请
    OBTAINING SPECTRAL INFORMATION FROM A MOVING OBJECT 审中-公开
    从移动对象获取光谱信息

    公开(公告)号:US20170038258A1

    公开(公告)日:2017-02-09

    申请号:US14944446

    申请日:2015-11-18

    Abstract: An optical device includes a waveplate sandwiched between first and second polarizers and is arranged to receive light emanating from an object or object image that is in motion relative to the optical device. A detector array includes one or more detector elements and is optically coupled to receive light from the second polarizer. Each detector element of the detector array provides an electrical output signal that varies according to intensity of the light received from the second polarizer. The intensity of the light is a function of relative motion of the object or the object image and the optical device and contains spectral information about an object point of the object.

    Abstract translation: 光学装置包括夹在第一和第二偏振器之间的波片,并且布置成接收从相对于光学装置运动的物体或物体图像发出的光。 检测器阵列包括一个或多个检测器元件,并被光耦合以接收来自第二偏振器的光。 检测器阵列的每个检测器元件提供根据从第二偏振器接收的光的强度而变化的电输出信号。 光的强度是物体或对象图像和光学装置的相对运动的函数,并且包含关于物体的物点的光谱信息。

    Analyzers with time variation based on color-coded spatial modulation
    9.
    发明授权
    Analyzers with time variation based on color-coded spatial modulation 有权
    基于颜色编码空间调制的时间变化分析仪

    公开(公告)号:US09341562B2

    公开(公告)日:2016-05-17

    申请号:US14155094

    申请日:2014-01-14

    Abstract: A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.

    Abstract translation: 滤波器装置可以发射和/或反射从移动物体发出的光,使得发射光具有时间变化,并且时间变化可以包括关于物体的信息,例如其类型。 例如,可以通过路径的区段发出光,并通过过滤器组件的位置进行透射/反射,并且位置的透射函数可以充分地不同,从而在区间之间的发光中发生时间变化。 或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射,从而根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。 可以使用许多过滤装置,例如 过滤器组件可以包括过滤器组件,其可以具有更简单的不均匀传输功能之一。 可以比较感测结果中的时变波形,以获得光谱差异。 在实用的商业实施例中,过滤器装置可以制造为一次性的,并且用于实际上在任何地方,以低成本使用的点护理装置,并且也可以在在线监测系统中实现。

    Controlling transfer of objects affecting optical characteristics
    10.
    发明授权
    Controlling transfer of objects affecting optical characteristics 有权
    控制影响光学特性的物体的传递

    公开(公告)号:US09307938B2

    公开(公告)日:2016-04-12

    申请号:US13686236

    申请日:2012-11-27

    Abstract: An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.

    Abstract translation: 诸如制品,装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。 该产品还可以包括流体组件,例如过滤器组件,其控制影响或移动光谱特征或特性的物体的转移,例如通过移动透射模式峰值或反射模式谷,移动相位,减小最大值或对比度,或增加中等强度宽度, 作为全宽半最大值(FWHM)。 分析物,例如 葡萄糖分子可以主要包括在一组物体中,其比其它物体更快地转移到分析物容器中,并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子,包括例如氯化钠。 因此,来自容器的输出光包括关于分析物的信息。

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