公开(公告)号：US11788957B2

公开(公告)日：2023-10-17

申请号：US17443873

申请日：2021-07-28

Applicant: Picomole Inc.

Inventor： Gisia Beydaghyan ,  Christopher Quentin Purves ,  Stephen Douglas Graham ,  Erik Justin Scheme ,  Angkoon Phinyomark

IPC: G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01N21/31 ,  G01J3/10 ,  G06N20/00 ,  G01N21/77

CPC classification number: G01N21/39 ,  G01J3/0205 ,  G01J3/10 ,  G01J3/42 ,  G01N1/40 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/552 ,  G01N33/497 ,  G01J2003/423 ,  G01N2021/391 ,  G01N2021/398 ,  G01N2021/7789 ,  G01N2033/4975 ,  G06N20/00

Abstract: Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.

公开(公告)号：US11105739B2

公开(公告)日：2021-08-31

申请号：US16740026

申请日：2020-01-10

Applicant: Picomole Inc.

Inventor： Gisia Beydaghyan ,  Christopher Quentin Purves ,  Stephen Douglas Graham ,  Erik Justin Scheme ,  Angkoon Phinyomark

IPC: G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01N21/31 ,  G01J3/10 ,  G06N20/00 ,  G01N21/77

Abstract: Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.