公开(公告)号：US11782049B2

公开(公告)日：2023-10-10

申请号：US16805142

申请日：2020-02-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves

IPC: G01N33/497 ,  A61B5/087 ,  A61B5/093 ,  G01N33/00 ,  G01N33/50 ,  A61B10/00

CPC classification number: G01N33/497 ,  A61B5/087 ,  A61B5/093 ,  G01N33/0009 ,  G01N33/5008 ,  A61B2010/0087 ,  G01N2033/4975

Abstract: An apparatus and method for collecting a breath sample are provided. The apparatus has a breath input interface configured to receive exhaled breath, a container connected to the breath input interface for receiving at least some of the exhaled breath, the container having a cavity with a volume that is controllable, and at least one controller configured to control the volume of the cavity to increase at a volume increase rate that is at most equal to a flow rate of the exhaled breath received by the breath input interface.

公开(公告)号：US20210267478A1

公开(公告)日：2021-09-02

申请号：US16805142

申请日：2020-02-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves

IPC: A61B5/087 ,  A61B5/093 ,  G01N33/497 ,  G01N33/00 ,  G01N33/50

Abstract: An apparatus and method for collecting a breath sample are provided. The apparatus has a breath input interface configured to receive exhaled breath, a container connected to the breath input interface for receiving at least some of the exhaled breath, the container having a cavity with a volume that is controllable, and at least one controller configured to control the volume of the cavity to increase at a volume increase rate that is at most equal to a flow rate of the exhaled breath received by the breath input interface.

公开(公告)号：US11788957B2

公开(公告)日：2023-10-17

申请号：US17443873

申请日：2021-07-28

Applicant: Picomole Inc.

Inventor： Gisia Beydaghyan ,  Christopher Quentin Purves ,  Stephen Douglas Graham ,  Erik Justin Scheme ,  Angkoon Phinyomark

IPC: G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01N21/31 ,  G01J3/10 ,  G06N20/00 ,  G01N21/77

CPC classification number: G01N21/39 ,  G01J3/0205 ,  G01J3/10 ,  G01J3/42 ,  G01N1/40 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/552 ,  G01N33/497 ,  G01J2003/423 ,  G01N2021/391 ,  G01N2021/398 ,  G01N2021/7789 ,  G01N2033/4975 ,  G06N20/00

Abstract: Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.

公开(公告)号：US11105739B2

公开(公告)日：2021-08-31

申请号：US16740026

申请日：2020-01-10

Applicant: Picomole Inc.

Inventor： Gisia Beydaghyan ,  Christopher Quentin Purves ,  Stephen Douglas Graham ,  Erik Justin Scheme ,  Angkoon Phinyomark

IPC: G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01N21/31 ,  G01J3/10 ,  G06N20/00 ,  G01N21/77

Abstract: Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.

公开(公告)号：US11499916B2

公开(公告)日：2022-11-15

申请号：US16599943

申请日：2019-10-11

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves ,  Denis Dufour

IPC: G01J3/26 ,  G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01N21/31 ,  G01J3/10 ,  G06N20/00 ,  G01N21/77

Abstract: A spectroscopy system is disclosed, and includes a resonant cavity, a first conduit configured to couple at a first end thereof to a gas source, and at a second end thereof to a first end of a sorbent tube containing a sample for analysis, and a second conduit configured to couple at a first end thereof to a second end of the sorbent tube, and at a second end thereof to the resonant cavity.

公开(公告)号：US20210267483A1

公开(公告)日：2021-09-02

申请号：US16805176

申请日：2020-02-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves

IPC: A61B5/097 ,  A61B5/08 ,  A61B5/095 ,  A61B5/0235

Abstract: An apparatus and method for collecting a breath sample are provided. The apparatus has a breath input interface configured to receive exhaled breath, a first conduit system connected to the breath input interface, a valve configured to control fluid communication between the first conduit system and at least one breath sample storage device configured to store a breath sample, an air circulation system configured to circulate air through the first conduit system upon completion of a first received exhaled breath, and at least one controller configured to control the valve upon completion of the first received exhaled breath at least partially based on a humidity level in the first conduit system.

公开(公告)号：US11506601B2

公开(公告)日：2022-11-22

申请号：US17160791

申请日：2021-01-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves ,  Perry F. Kain ,  Denis Dufour

IPC: G01J3/45 ,  G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01N21/31 ,  G01J3/10 ,  G06N20/00 ,  G01N21/77

Abstract: There is provided a resonant cavity system. A first mirror is actuated at a first end of a resonant cavity to move in a direction between a first position relative to a second mirror at a second end of the resonant cavity, at which a cavity length between the first mirror and the second mirror is less than a resonance length for a laser beam, and a second position relative to the second mirror, at which the cavity length is greater than the resonance length. An event is triggered when the cavity length is proximal to the resonance length. The first mirror is continuously actuated to move in the direction between the first position and the second position during the event.

公开(公告)号：US20210267482A1

公开(公告)日：2021-09-02

申请号：US16805161

申请日：2020-02-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves

IPC: A61B5/097 ,  A61B10/00 ,  A61B5/083 ,  A61B5/087 ,  A61B5/00

Abstract: An apparatus and method for collecting a breath sample are provided. The apparatus includes a breath input interface configured to receive exhaled breath, a metering device configured to determine a constituent level in the breath being received, a first conduit system extending from the breath input interface and connected to at least one breath sample storage device, a valve positioned along the first conduit system to control a flow of the exhaled breath towards the at least one breath sample storage device, and at least one controller configured to determine if the constituent level is within a constituent level target range, if a change rate in the constituent level is within a constituent level change rate target range, and control the valve to open at least partially based on these conditions.

公开(公告)号：US11035789B2

公开(公告)日：2021-06-15

申请号：US16509207

申请日：2019-07-11

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves ,  Denis Dufour

IPC: G01N21/31 ,  G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01J3/10 ,  G06N20/00 ,  G01N21/77

Abstract: A cavity ring-down spectroscopy system and a method of modulating a light beam therein are provided. The cavity ring-down spectroscopy system includes at least one laser that generates a light beam, a first optical modulator positioned to attenuate the light beam from the at least one laser, a second optical modulator positioned to attenuate the light beam from the first optical modulator, a ring-down cavity positioned to receive the light beam from the second optical modulator, and at least one light sensor to detect an intensity of light leaked from the ring-down cavity.

公开(公告)号：US11957450B2

公开(公告)日：2024-04-16

申请号：US16805176

申请日：2020-02-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin Purves

IPC: A61B5/097 ,  A61B5/0235 ,  A61B5/08 ,  A61B5/095

CPC classification number: A61B5/097 ,  A61B5/0235 ,  A61B5/082 ,  A61B5/095 ,  A61B2560/02 ,  A61B2560/04

Abstract: An apparatus and method for collecting a breath sample are provided. The apparatus has a breath input interface configured to receive exhaled breath, a first conduit system connected to the breath input interface, a valve configured to control fluid communication between the first conduit system and at least one breath sample storage device configured to store a breath sample, an air circulation system configured to circulate air through the first conduit system upon completion of a first received exhaled breath, and at least one controller configured to control the valve upon completion of the first received exhaled breath at least partially based on a humidity level in the first conduit system.