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公开(公告)号：US11850262B2
公开(公告)日：2023-12-26
申请号：US16489455
申请日：2018-02-28
Applicant: Purdue Research Foundation , Endocyte, Inc.
Inventor： Philip Stewart Low , Haiyan Chu , Yong Gu Lee , Yingjuan J. Lu , Christopher Paul Leamon , Leroy W. Wheeler, II
IPC: A61K31/17 , A61K35/17 , C07K14/705 , C07K16/30
CPC classification number: A61K35/17 , C07K14/70503 , C07K16/30 , C07K2317/622 , C07K2319/03 , C07K2319/033
Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
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公开(公告)号：US20170290900A1
公开(公告)日：2017-10-12
申请号：US15296666
申请日：2016-10-18
Applicant: Purdue Research Foundation
Inventor： Philip S. Low , Haiyan Chu , Yong Gu Lee
IPC: A61K39/00
Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.
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公开(公告)号：US12150981B2
公开(公告)日：2024-11-26
申请号：US17387892
申请日：2021-07-28
Applicant: Purdue Research Foundation
Inventor： Philip S. Low , Haiyan Chu , Yong Gu Lee
Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.
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公开(公告)号：US11759480B2
公开(公告)日：2023-09-19
申请号：US16921400
申请日：2020-07-06
Applicant: ENDOCYTE, INC. , PURDUE RESEARCH FOUNDATION
Inventor： Philip Stewart Low , Haiyan Chu , Yong Gu Lee , Yingjuan J. Lu , Christopher Paul Leamon , Leroy W Wheeler, II
IPC: A61K35/17 , C07K14/705 , C07K16/30
CPC classification number: A61K35/17 , C07K14/70503 , C07K16/30 , C07K2317/622 , C07K2319/03 , C07K2319/033
Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
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Patent Agency Ranking
公开(公告)号：US20250144195A1
公开(公告)日：2025-05-08
申请号：US18915595
申请日：2024-10-15
Applicant: Purdue Research Foundation
Inventor： Philip S. LOW , Haiyan Chu , Yong Gu Lee
Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.
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公开(公告)号：US12269862B2
公开(公告)日：2025-04-08
申请号：US18459302
申请日：2023-08-31
Applicant: PURDUE RESEARCH FOUNDATION , ENDOCYTE, INC. , SEATTLE CHILDREN'S HOSPITAL
Inventor： Philip Stewart Low , Haiyan Chu , Yingjuan June Lu , Christopher Paul Leamon , Leroy W. Wheeler, II , Michael C. Jensen , James Matthaei
IPC: C07K14/725 , A61K9/00 , A61K31/365 , A61K31/519 , A61K38/17 , A61K39/00 , A61P35/00 , C07K16/44 , C07K16/46 , C12N5/0783
Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
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公开(公告)号：US12240870B2
公开(公告)日：2025-03-04
申请号：US16971801
申请日：2019-02-22
Applicant: Purdue Research Foundation , ENDOCYTE, INC. , SEATTLE CHILDREN'S HOSPITAL
Inventor： Richard Messmann , Christopher Paul Leamon , Haiyan Chu , Yingjuan June Lu , Philip Stewart Low , Michael C. Jensen , James Matthaei , Navin Robert Charles Pinto , Julie Ruggieri Park
IPC: A61K39/00 , A61K47/55 , A61P35/00 , C07K14/705
Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
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公开(公告)号：US12144850B2
公开(公告)日：2024-11-19
申请号：US16092054
申请日：2017-04-07
Applicant: PURDUE RESEARCH FOUNDATION , ENDOCYTE, INC.
Inventor： Philip Stewart Low , Haiyan Chu , Yong Gu Lee
IPC: A61K39/00 , A61K9/00 , A61K35/12 , A61K35/17 , A61K39/395 , A61K47/54 , A61K47/55 , A61K48/00 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/44 , C12N15/86
Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
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公开(公告)号：US11779602B2
公开(公告)日：2023-10-10
申请号：US16253562
申请日：2019-01-22
Applicant: ENDOCYTE, INC. , PURDUE RESEARCH FOUNDATION , SEATTLE CHILDREN'S HOSPITAL
Inventor： Philip Stewart Low , Haiyan Chu , Yingjuan June Lu , Christopher Paul Leamon , Leroy W. Wheeler, II , Michael C. Jensen , James Matthaei
IPC: A61K35/17 , C07K14/725 , C12N5/0783 , A61P35/00 , A61K9/00 , A61K31/365 , A61K31/519 , A61K38/17 , C07K16/44 , C07K16/46
CPC classification number: A61K35/17 , A61K9/0019 , A61K9/0053 , A61K31/365 , A61K31/519 , A61K38/1774 , A61P35/00 , C07K14/7051 , C07K16/44 , C07K16/46 , C12N5/0638 , C07K2317/622
Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
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