公开(公告)号：US20250144195A1

公开(公告)日：2025-05-08

申请号：US18915595

申请日：2024-10-15

Applicant: Purdue Research Foundation

Inventor： Philip S. LOW ,  Haiyan Chu ,  Yong Gu Lee

IPC: A61K39/00 ,  A61K35/17 ,  A61K40/11 ,  A61K40/31 ,  A61K47/54 ,  A61K47/55 ,  A61K47/60 ,  A61K47/69

Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.

公开(公告)号：US12144850B2

公开(公告)日：2024-11-19

申请号：US16092054

申请日：2017-04-07

Applicant: PURDUE RESEARCH FOUNDATION ,  ENDOCYTE, INC.

Inventor： Philip Stewart Low ,  Haiyan Chu ,  Yong Gu Lee

IPC: A61K39/00 ,  A61K9/00 ,  A61K35/12 ,  A61K35/17 ,  A61K39/395 ,  A61K47/54 ,  A61K47/55 ,  A61K48/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/44 ,  C12N15/86

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US12150981B2

公开(公告)日：2024-11-26

申请号：US17387892

申请日：2021-07-28

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Haiyan Chu ,  Yong Gu Lee

IPC: A61K47/54 ,  A61K35/17 ,  A61K39/00 ,  A61K47/55 ,  A61K47/60 ,  A61K47/69

Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.

公开(公告)号：US11759480B2

公开(公告)日：2023-09-19

申请号：US16921400

申请日：2020-07-06

Applicant: ENDOCYTE, INC. ,  PURDUE RESEARCH FOUNDATION

Inventor： Philip Stewart Low ,  Haiyan Chu ,  Yong Gu Lee ,  Yingjuan J. Lu ,  Christopher Paul Leamon ,  Leroy W Wheeler, II

IPC: A61K35/17 ,  C07K14/705 ,  C07K16/30

CPC classification number: A61K35/17 ,  C07K14/70503 ,  C07K16/30 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/033

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US11850262B2

公开(公告)日：2023-12-26

申请号：US16489455

申请日：2018-02-28

Applicant: Purdue Research Foundation ,  Endocyte, Inc.

Inventor： Philip Stewart Low ,  Haiyan Chu ,  Yong Gu Lee ,  Yingjuan J. Lu ,  Christopher Paul Leamon ,  Leroy W. Wheeler, II

IPC: A61K31/17 ,  A61K35/17 ,  C07K14/705 ,  C07K16/30

CPC classification number: A61K35/17 ,  C07K14/70503 ,  C07K16/30 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/033

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US20170290900A1

公开(公告)日：2017-10-12

申请号：US15296666

申请日：2016-10-18

Applicant: Purdue Research Foundation

Inventor： Philip S. Low ,  Haiyan Chu ,  Yong Gu Lee

IPC: A61K39/00

Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.