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公开(公告)号:US20190127812A1
公开(公告)日:2019-05-02
申请号:US16165415
申请日:2018-10-19
Applicant: Purdue Research Foundation
Inventor: Lynne S. Taylor , Lisa J. Mauer , Alpana Thorat
Abstract: The present disclosure relates to a novel method of inhibiting sugar crystallization and/or sugar crystal growth with at least one glycoside as the sugar crystallization and/or sugar crystal growth inhibitor, and novel compositions comprising amorphous sugar and at least one glycoside as the sugar crystallization and/or sugar crystal growth inhibitor.
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公开(公告)号:US12076444B2
公开(公告)日:2024-09-03
申请号:US18152394
申请日:2023-01-10
Applicant: Purdue Research Foundation
Inventor: Arun V. Giridhar , Michael Harris , Gintaras V. Reklaitis , Lynne S. Taylor , Zoltan K. Nagy , Elcin Icten , Frederick Fiesser , Laura Hirshfield
IPC: A61K9/70 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/38 , B01J4/00 , B01J4/02
CPC classification number: A61K9/7007 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/38 , B01J4/002 , B01J4/008 , B01J4/02 , B01J2204/005 , B01J2204/007
Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.
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公开(公告)号:US20220298265A1
公开(公告)日:2022-09-22
申请号:US17836338
申请日:2022-06-09
Inventor: Kevin J. Edgar , Brittany L.B. Nichols , Junyi Chen , Charles Frazier , Lynne S. Taylor , Laura I. Mosquera-Giraldo , Ann Norris , Benjamin Adams
Abstract: A method for the synthesis of alkyl ω-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ω-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.
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公开(公告)号:US20190367498A1
公开(公告)日:2019-12-05
申请号:US16423321
申请日:2019-05-28
Applicant: Purdue Research Foundation
Inventor: Lynne S. Taylor , Lisa J. Mauer , Vivekanand Bhardwaj
IPC: C07D417/06 , C07C55/10 , C07C57/13 , C07D213/80 , C07C51/41
Abstract: The present disclosure relates to novel thiamine-organic acid salt, and the method of making the novel thiamine-organic acid salt.
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公开(公告)号:US20180228737A1
公开(公告)日:2018-08-16
申请号:US15751771
申请日:2016-08-09
Applicant: Purdue Research Foundation
Inventor: Arun V. Giridhar , Michael Harris , Gintaras V. Raklaitis , Lynne S. Taylor , Zoltan K. Nagy , Elcin Icten , Frederick Fiesser , Laura Hirshfield
IPC: A61K9/70 , B01J4/00 , B01J4/02 , A61K31/192 , A61K47/34 , A61K47/38 , A61K31/635 , A61K31/167 , A61K31/196 , A61K47/14
CPC classification number: A61K9/7007 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/415 , A61K31/635 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/38 , B01J4/002 , B01J4/008 , B01J4/02 , B01J2204/005 , B01J2204/007
Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.
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公开(公告)号:US12162962B2
公开(公告)日:2024-12-10
申请号:US17836338
申请日:2022-06-09
Inventor: Kevin J. Edgar , Brittany L. B. Nichols , Junyi Chen , Charles Frazier , Lynne S. Taylor , Laura I. Mosquera-Giraldo , Ann Norris
Abstract: A method for the synthesis of alkyl ω-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ω-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.
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公开(公告)号:US11547675B2
公开(公告)日:2023-01-10
申请号:US15751771
申请日:2016-08-09
Applicant: Purdue Research Foundation
Inventor: Arun V. Giridhar , Michael Harris , Gintaras V. Reklaitis , Lynne S. Taylor , Zoltan K. Nagy , Elcin Icten , Frederick Fiesser , Laura Hirshfield
IPC: A61K9/70 , A61K47/10 , A61K31/415 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/635 , A61K47/14 , A61K47/34 , A61K47/38 , B01J4/00 , B01J4/02
Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.
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