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公开(公告)号：US09784960B2
公开(公告)日：2017-10-10
申请号：US14735959
申请日：2015-06-10
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Charles Addison Bouman , Ryan Douglas Muir , Shane Sullivan , Justin Allen Newman , Mark Carlsen , Suhas Sreehari
CPC classification number: G02B21/0084 , G02B21/0048 , G02B21/0076 , G02B26/101
Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
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公开(公告)号：US20200174142A1
公开(公告)日：2020-06-04
申请号：US16209938
申请日：2018-12-04
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Ryan Douglas Muir , Nicholas Roman Pogranichniy
Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.0 keV data can be analytically separated to recover the monochromatic images through simple linear fitting.
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公开(公告)号：US20160004060A1
公开(公告)日：2016-01-07
申请号：US14735959
申请日：2015-06-10
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Charles Addison Bouman , Ryan Douglas Muir , Shane Sullivan , Justin Allen Newman , Mark Carlsen
CPC classification number: G02B21/0084 , G02B21/0048 , G02B21/0076 , G02B26/101
Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
Abstract translation: 描述了用于在多个同时数据采集通道上实现高达kHz帧频光学成像的波束扫描光学设计。 在一个实施例中，两个快速扫描谐振反射镜将光束引导通过视场的迂回轨迹，轨迹重复时间由反射镜周期的最小公倍数给出。 将原始时域数据划分为与基于模型的图像重建（MBIR）相结合的子轨迹。3D绘图算法允许比Lissajous轨迹的重复时间高得多的有效帧速率。 因为子轨迹和全轨迹成像是分析相同数据的不同方法，同时获取具有较低分辨率的高帧率图像和高分辨率的低帧率图像。
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公开(公告)号：US10145968B2
公开(公告)日：2018-12-04
申请号：US14708335
申请日：2015-05-11
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Ryan Douglas Muir , Nicholas Roman Pogranichniy
Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.0 keV data can be analytically separated to recover the monochromatic images through simple linear fitting.
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公开(公告)号：US10416068B2
公开(公告)日：2019-09-17
申请号：US14484248
申请日：2014-09-11
Applicant: Purdue Research Foundation
Inventor： Garth Jason Simpson , Ryan Douglas Muir , Shane Zachary Sullivan
Abstract: A quantitative optical microscopy arrangement is described. Specifically, a digital filter derived from linear discriminant analysis is described for recovering impulse responses in applications that may include photon counting from a high speed photodetector and applied to remove ringing distortions from impedance mismatch in multiphoton fluorescence microscopy. Training of the digital filter is achieved by defining temporally coincident and non-coincident transients and identifying the projection within filter-space that best separates the two classes. The training allows rapid data analysis by digital filtering. The LDA filter is also capable of recovering deconvolved impulses for single photon counting from highly distorted ringing waveforms from an impedance mismatched photomultiplier tube. The LDA filter is also successful in removing these ringing distortions from two-photon excited fluorescence micrographs and may extend the dynamic range of photon counting by about three orders of magnitude through minimization of detector paralysis.
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Patent Agency Ranking
公开(公告)号：US10409047B2
公开(公告)日：2019-09-10
申请号：US15724738
申请日：2017-10-04
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Charles Addison Bouman , Ryan Douglas Muir , Shane Sullivan , Justin Allen Newman , Mark Carlsen , Suhas Sreehari
Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
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公开(公告)号：US20150323687A1
公开(公告)日：2015-11-12
申请号：US14708335
申请日：2015-05-11
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Ryan Douglas Muir , Nicholas Roman Pogranichniy
Abstract: The present disclosure provides a system and method for efficiently mining multi-threshold measurements acquired using photon counting pixel-array detectors for spectral imaging and diffraction analyses. Images of X-ray intensity as a function of X-ray energy were recorded on a 6 megapixel X-ray photon counting array detector through linear fitting of the measured counts recorded as a function of counting threshold. An analytical model is disclosed for describing the probability density of detected voltage, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across multiple pixels. Three-parameter fits to the model were independently performed for each pixel in the array for X-ray scattering images acquired for 13.5 keV and 15.0 keV X-ray energies. From the established pixel responses, multi-threshold composite images produced from the sum of 13.5 keV and 15.0 keV data can be analytically separated to recover the monochromatic images through simple linear fitting.
Abstract translation: 本公开提供了一种用于有效挖掘使用光子计数像素阵列检测器获得的用于光谱成像和衍射分析的多阈值测量的系统和方法。 作为X射线能量的函数的X射线强度的图像通过线性拟合作为计数阈值的函数记录的测量计数记录在6百万像素的X射线光子计数阵列检测器上。 公开了一种用于描述检测电压的概率密度的分析模型，利用分数光子计数来解释跨越多个像素的电压羽流的边缘/角落效应。 针对13.5 keV和15.0 keV X射线能量获得的X射线散射图像，阵列中的每个像素独立地执行与模型的三参数拟合。 从建立的像素响应中，可以分析地从13.5 keV和15.0 keV数据的总和产生的多阈值合成图像通过简单的线性拟合来恢复单色图像。
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公开(公告)号：US10162942B2
公开(公告)日：2018-12-25
申请号：US15702383
申请日：2017-09-12
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Ryan Douglas Muir , David Joseph Kissick
Abstract: A method and apparatus for photon, ion or particle counting described that provides seven orders of magnitude of linear dynamic range (LDR) for a single detector. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons, ions or particles present, the binomial distribution of observed counts for a given threshold, the mean number of photons, ions or particles can be determined well beyond the conventional limit.
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公开(公告)号：US20180068090A1
公开(公告)日：2018-03-08
申请号：US15702383
申请日：2017-09-12
Applicant: Purdue Research Foundation
Inventor： Garth Jason Simpson , Ryan Douglas Muir , David Joseph Kissick
CPC classification number: G06F19/707 , G01J1/16 , G01J1/42 , G01J2001/442 , G01T1/17
Abstract: A method and apparatus for photon, ion or particle counting described that provides seven orders of magnitude of linear dynamic range (LDR) for a single detector. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons, ions or particles present, the binomial distribution of observed counts for a given threshold, the mean number of photons, ions or particles can be determined well beyond the conventional limit.
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公开(公告)号：US20180045939A1
公开(公告)日：2018-02-15
申请号：US15724738
申请日：2017-10-04
Applicant: PURDUE RESEARCH FOUNDATION
Inventor： Garth Jason Simpson , Charles Addison Bouman , Ryan Douglas Muir , Shane Sullivan , Justin Allen Newman , Mark Carlsen , Suhas Sreehari
CPC classification number: G02B21/0084 , G02B21/0048 , G02B21/0076 , G02B26/101
Abstract: A beam-scanning optical design is described for achieving up to kHz frame-rate optical imaging on multiple simultaneous data acquisition channels. In one embodiment, two fast-scan resonant mirrors direct the optical beam on a circuitous trajectory through the field of view, with the trajectory repeat-time given by the least common multiplier of the mirror periods. Dicing the raw time-domain data into sub-trajectories combined with model-based image reconstruction (MBIR) 3D in-painting algorithms allows for effective frame-rates much higher than the repeat time of the Lissajous trajectory. Because sub-trajectory and full-trajectory imaging are different methods of analyzing the same data, both high-frame rate images with relatively low resolution and low frame rate images with high resolution are simultaneously acquired.
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