公开(公告)号：US20040241315A1

公开(公告)日：2004-12-02

申请号：US10889341

申请日：2004-07-12

Applicant: Regents of the University of Minnesota

Inventor： David Y.H. Pui ,  Da-Ren Chen

IPC: A61L002/00 ,  B05D003/00

CPC classification number: B05B5/032 ,  A61F2/86 ,  B05B1/14 ,  B05B5/025 ,  B05B5/0255 ,  B05B5/08 ,  B05B5/087 ,  B05B7/0408 ,  B05B7/066 ,  B05B13/06

Abstract: Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.

公开(公告)号：US20040177807A1

公开(公告)日：2004-09-16

申请号：US10809660

申请日：2004-03-25

Applicant: Regents of the University of Minnesota

Inventor： David Y.H. Pui ,  Da-Ren Chen

IPC: B05D001/04 ,  C12M001/42

CPC classification number: B01J2/006 ,  A61K39/00 ,  A61K48/00 ,  B01J2/04 ,  B01J2219/00371 ,  B01J2219/00436 ,  B05B5/025 ,  B05B5/03 ,  B05B5/0533 ,  B05B5/081 ,  B05B5/082 ,  B05B5/084 ,  B05B5/087 ,  B05B13/04 ,  C12M35/02 ,  C12N15/8207 ,  C12N15/87 ,  C12N15/895

Abstract: An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A spray of microdroplets suspending at least the particles is established forward of the spray dispenser end by creating a nonuniform electrical field between the spray dispenser end and an electrode electrically isolated therefrom. The particles are coated with at least a portion of the coating material as the microdroplet evaporates. For example, the suspension may include biological material particles.

Abstract translation: 使用电喷雾装置和/或方法来涂覆颗粒。 例如，可以通过喷雾分配器端部的至少一个开口提供包括至少一个液体悬浮液的流。 流动至少包括颗粒和涂层材料。 通过在喷雾分配器端部与与其分离的电极之间产生不均匀的电场，在喷雾分配器端的前方建立悬浮至少颗粒的微滴喷雾。 当微滴蒸发时，颗粒被涂覆有至少一部分涂层材料。 例如，悬浮液可以包括生物材料颗粒。