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公开(公告)号：US20220293404A1
公开(公告)日：2022-09-15
申请号：US17805133
申请日：2022-06-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Andrea Geistanger , Daniel Intelmann , Shirin Shahriari , Anton Hilger
IPC: H01J49/00
Abstract: A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function fp for a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fp describes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fp is a parametrized function fp(concentration), with p=(p1,p2, . . . pn) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)}1,{circumflex over (p)}2, . . . {circumflex over (p)}n) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.
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公开(公告)号：US11585791B2
公开(公告)日：2023-02-21
申请号：US17113354
申请日：2020-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Albert Geiger , Daniel Intelmann , Ruediger Laubender , Julian Michely , Kirill Tarasov
Abstract: A method for monitoring an analyzer including a liquid chromatography device (LC) having at least two liquid chromatography (LC) streams, the method including continuously monitoring one or more parameters in measurement data of samples in each of the at least two LC streams, the one or more parameters being independent of an analyte concentration of the respective sample, determining if the one or more monitored parameters show an expected behavior and triggering a response upon detection that the one or more monitored parameters deviate from the expected behavior.
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公开(公告)号：US20230333122A1
公开(公告)日：2023-10-19
申请号：US18333347
申请日：2023-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Daniel Intelmann , Peter Heiss
CPC classification number: G01N33/743 , G01N30/72 , G01N30/8624 , G01N30/88 , G01N33/96 , G01N2030/8813 , G01N2333/575 , G01N2496/00
Abstract: The present invention relates to a method for providing a verified analyte measurement of a sample with a chromatography mass spectrometer device, said method comprising the following steps: a) admixing an interferent monitoring compound and, optionally an internal standard, to the sample; b) determining a chromatogram of the sample by acquiring a plurality of data points for signal intensities over time for said interferent monitoring compound, said analyte, and optionally said internal standard; and c) comparing a property of an interferent monitoring compound peak to a property of an internal standard peak and/or to a property of an analyte peak; and to methods and systems related thereto.
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公开(公告)号：US20230326729A1
公开(公告)日：2023-10-12
申请号：US18333174
申请日：2023-06-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Benjamin Tiemann , Daniel Intelmann
CPC classification number: H01J49/0009 , H01J49/063 , H01J49/0031 , H01J49/009 , G01N30/724
Abstract: A method for optimizing at least one parameter setting of at least one mass spectrometry device (110) operating at unit resolution is disclosed. The method comprises the following steps:
a) determining at least one analyte detection window for detecting an analyte of interest with the mass spectrometry device (110), wherein the analyte detection window is defined by a central mass to charge ratio value of the analyte and a predefined width, wherein the central mass to charge ratio value of the analyte is set to a theoretical mass to charge ratio value of the analyte of interest having more than one decimal place and/or a mass to charge ratio value of the analyte of interest determined by a high resolution mass spectrometry measurement having more than one decimal place;
b) determining at least one internal standard detection window for detecting an internal standard substance with the mass spectrometry device (110), wherein the internal standard detection window is defined by a central mass to charge ratio value of the internal standard substance and the pre-defined width, wherein the central mass to charge ratio value of the internal standard substance is set to a mass to charge ratio value of the internal standard substance calculated relative to the analyte of interest and having more than one decimal place and/or to a mass to charge ratio value of the internal standard substance determined by a high resolution mass spectrometry measurement having more than one decimal place.-
5.发明申请公开(公告)号：US20220308024A1
公开(公告)日：2022-09-29
申请号：US17806764
申请日：2022-06-14
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Nadja Arens , Andrea Geistanger , Anton Hilger , Daniel Intelmann , Shirin Shahriari
Abstract: A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sijk is acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.
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Patent Agency Ranking
公开(公告)号：US12159773B2
公开(公告)日：2024-12-03
申请号：US17809760
申请日：2022-06-29
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Nadja Arens , Daniel Intelmann
Abstract: Systems for analyzing a biological sample include a separation unit configured to separate a component from the biological sample, an ionization unit configured to generate a plurality of ions from the component, an adjustable mass-selective filtering element, a detector configured to detect ions that pass through the mass-selective filtering element, and a controller connected to the mass-selective filtering element and to the detector, where the controller is configured so that during operation of the system, the controller adjusts the mass-selective filtering element and activates the detector to measure at least three different ion signals corresponding to the plurality of ions, and determines a mass axis shift of the system based on the at least three different ion signals.
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7.发明授权公开(公告)号：US11982657B2
公开(公告)日：2024-05-14
申请号：US17806764
申请日：2022-06-14
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Nadja Arens , Andrea Geistanger , Anton Hilger , Daniel Intelmann , Shirin Shahriari
CPC classification number: G01N30/8665 , G01N30/7233
Abstract: A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sijk is acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.
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公开(公告)号：US20220328295A1
公开(公告)日：2022-10-13
申请号：US17809760
申请日：2022-06-29
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Nadja Arens , Daniel Intelmann
Abstract: Systems for analyzing a biological sample include a separation unit configured to separate a component from the biological sample, an ionization unit configured to generate a plurality of ions from the component, an adjustable mass-selective filtering element, a detector configured to detect ions that pass through the mass-selective filtering element, and a controller connected to the mass-selective filtering element and to the detector, where the controller is configured so that during operation of the system, the controller adjusts the mass-selective filtering element and activates the detector to measure at least three different ion signals corresponding to the plurality of ions, and determines a mass axis shift of the system based on the at least three different ion signals.
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公开(公告)号：US20210190736A1
公开(公告)日：2021-06-24
申请号：US17113354
申请日：2020-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Albert Geiger , Daniel Intelmann , Ruediger Laubender , Julian Michely , Kirill Tarasov
IPC: G01N30/72
Abstract: A method for monitoring an analyzer including a liquid chromatography device (LC) having at least two liquid chromatography (LC) streams, the method including continuously monitoring one or more parameters in measurement data of samples in each of the at least two LC streams, the one or more parameters being independent of an analyte concentration of the respective sample, determining if the one or more monitored parameters show an expected behavior and triggering a response upon detection that the one or more monitored parameters deviate from the expected behavior.
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公开(公告)号：US12074015B2
公开(公告)日：2024-08-27
申请号：US17805133
申请日：2022-06-02
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Andrea Geistanger , Daniel Intelmann , Shirin Shahriari , Anton Hilger
IPC: H01J49/00
CPC classification number: H01J49/0009
Abstract: A method for calibrating at least one mass spectrometry device having a first defined hardware configuration comprises at least one manufacturer-site pre-calibration step establishing at least one reference calibration function fp for a generic type of mass spectrometry devices having a second defined hardware configuration, wherein the second defined hardware configuration is equivalent to the first defined hardware configuration, wherein the reference calibration function fp describes a relationship of at least one concentration c of at least one analyte in at least one calibrator sample, wherein the reference calibration function fp is a parametrized function fp(concentration), with p=(p1,p2, . . . pn) being a set of parameters of the reference calibration function and n being a positive integer; determining calibration values {circumflex over (p)}=({circumflex over (p)}1,{circumflex over (p)}2, . . . {circumflex over (p)}n) for the set of parameters of the reference calibration function for the generic type of mass spectrometry devices.
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