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公开(公告)号：US11287402B2
公开(公告)日：2022-03-29
申请号：US17113164
申请日：2020-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Marian Roetzer , Florian Schweinberger , Benjamin Tiemann , Marius Wagner , Ralf Zimmermann
Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
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公开(公告)号：US20210181166A1
公开(公告)日：2021-06-17
申请号：US17113164
申请日：2020-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Stefan Quint , Marian Roetzer , Florian Schweinberger , Benjamin Tiemann , Marius Wagner , Ralf Zimmermann
Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
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