公开(公告)号：US20240228495A1

公开(公告)日：2024-07-11

申请号：US17913824

申请日：2021-03-24

Applicant: SRI INTERNATIONAL

Inventor： Thomas R. Webb ,  Chandraiah Lagisetti ,  Diane Beylkin ,  Jaehyeon Park ,  Wei Zhou ,  Peter Madrid ,  Leyi Gong ,  Jeremiah Malerich ,  Chat Gheong Gabriel Fung ,  Raymond Ng ,  Quentin Perron ,  Vinicius Barros Ribeiro da Silva

IPC: C07D487/04 ,  A61K31/519 ,  A61K31/551 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/551 ,  A61K45/06

Abstract: The present disclosure is concerned with 9-hydroxy-6-(pyrrolidin-2-yl)-3, 4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione compounds for the treatment of various viral infections such as, for example, influenza virus. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230117592A1

公开(公告)日：2023-04-20

申请号：US17788275

申请日：2020-12-18

Applicant: SRI International

Inventor： Ling Jong ,  Nathan Collins ,  Raymond Ng

IPC: C07C217/86 ,  C07C217/92 ,  C07D215/38 ,  C07D213/74 ,  C07D249/08 ,  C07D403/12 ,  C07D401/12 ,  C07D409/12 ,  C07D405/06 ,  C07D209/14 ,  C07C211/53 ,  C07D309/04 ,  C07D305/08 ,  C07D295/13 ,  C07C211/54 ,  C07D413/12 ,  C07D405/12 ,  C07C211/56 ,  C07D403/06 ,  C07D405/14

Abstract: Various embodiments of the present disclosure are directed to compounds having Formula I, Formula II, Formula IIA, Formula III, Formula IIIA, Formula IIIB, and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases and/or treating associated diseases. In some embodiments, subject compounds are used to prepare a composition that is effective in treating neurodegenerative diseases.

公开(公告)号：US20230174485A1

公开(公告)日：2023-06-08

申请号：US17906885

申请日：2021-03-25

Applicant: SRI International

Inventor： Ling Jong ,  Raymond Ng ,  Nathan Collins

IPC: C07D209/88 ,  C07D403/12 ,  C07D471/04 ,  C07D495/04 ,  C07D487/04 ,  C07D471/22 ,  C07D403/04 ,  C07D405/14 ,  C07D401/12 ,  C07D209/86 ,  C07D223/28

CPC classification number: C07D209/88 ,  C07D403/12 ,  C07D471/04 ,  C07D495/04 ,  C07D487/04 ,  C07D471/22 ,  C07D403/04 ,  C07D405/14 ,  C07D401/12 ,  C07D209/86 ,  C07D223/28

Abstract: Various embodiments of the present disclosure are directed to compounds having Formula (I), Formula (IA), Formula (IB), Formula (IC), Formula (ID), Formula (IE), and/or pharmaceutically acceptable salts thereof. The compounds can be suitable for inhibiting lipoxygenases, and/or treating associated diseases, such as Alzheimer's disease. In some embodiments, the compounds may be administered to a patient as part of a pharmaceutical formulation.