公开(公告)号：US20190091673A1

公开(公告)日：2019-03-28

申请号：US15745361

申请日：2016-07-15

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Eric STERN ,  Aleksandar VACIC ,  Alec Nathanson FLYER ,  Benjamin SPEARS ,  Susan CLARDY

IPC: B01J31/16 ,  B01J31/18 ,  B01J35/00 ,  C09K11/07 ,  G01N33/58

Abstract: Nanoparticles for use in assay methods for detecting analytes in samples, which comprise a signal inducing agent, e.g. a transition-metal catalyst or a chemiluminophore, a chemiluminophore precursor, a soluble absorber, or a soluble absorber precursor. After binding to an analyte, the nanoparticle is dissociated by a chemical or physical trigger, e.g. an organic solvent or ultrasound, to release the signal inducing agent, which releases a detectable signal via a physical or chemical reaction. The nanoparticles comprising a chemiluminophore, a chemiluminophore precursor, a soluble absorber, or a soluble absorber precursor can also effect chemical reactions that serve as signal amplifiers.

公开(公告)号：US20180275058A1

公开(公告)日：2018-09-27

申请号：US15756938

申请日：2016-09-02

Applicant: SeLux Diagnostics, Inc.

Inventor： Eric STERN ,  Aleksandar VACIC ,  Nathan B. PURMORT

IPC: G01N21/64 ,  B01L3/00 ,  G01J3/44 ,  G01N21/69 ,  G01N21/76

CPC classification number: G01N21/6428 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0605 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0688 ,  B82Y15/00 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/03 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6489 ,  G01N21/69 ,  G01N21/76 ,  G01N2021/0321 ,  G01N2021/0328 ,  G01N2021/0346 ,  G01N2021/6482 ,  G01N2201/0245

Abstract: In some aspects, reader systems for optically detecting binding agents or analyte complexes in a sample as a result of performing biochemical assays can include: a housing defining a positioning receptacle to receive the sample; an excitation source to generate incident light directed at the sample; at least one solid-state photomultiplier detector configured to: i) receive a light emitted by at least one label associated with the binding agents and/or analyte complexes within the sample; and ii) produce a signal in response to receiving the light emitted by the at least one label or substrate solution that is physically or chemically modified by the said label, the at least one detector being connected to integrated signal processing electronics to process the signal; and a user interface in communication with the signal processing electronics for conveying one or more results of the one or more biochemical as says.