公开(公告)号：US20250044571A1

公开(公告)日：2025-02-06

申请号：US18887633

申请日：2024-09-17

Applicant: Standard BioTools Canada Inc.

Inventor： Daaf Sandkuijl ,  Alexander V. Loboda ,  Adam Carew ,  Khashayar Askarpour

IPC: G02B21/24 ,  G01N1/04 ,  G01N33/543 ,  G02B21/00 ,  G02B21/26 ,  H01J49/00 ,  H01J49/10

Abstract: We describe in this application systems and methods for autofocusing in imaging mass spectrometry. The present application describes improvements over current IMS and IMC apparatus and methods through an autofocus component including a plurality of apertures in the autofocus system, such as a plurality of apertures arranged in 2 dimensions. As a plurality of apertures is used, the autofocus system provides redundancy in the event that measurement of focus on the sample from the illuminating radiation passed through one or more of the apertures fails so as to reduce the number of unsuccessful autofocus attempts.