公开(公告)号：US20250093252A1

公开(公告)日：2025-03-20

申请号：US18726639

申请日：2023-01-09

Applicant: Standard BioTools Canada Inc.

Inventor： Alexander Loboda ,  Adam Carew

IPC: G01N15/1404 ,  G01N15/10 ,  H01J49/00 ,  H01J49/04 ,  H01J49/10

Abstract: A coupling tube made of a stretchable elastomeric material. The “stretchy” coupling tubing allows for improved reliability/repeatability of coupling performance. For example, the stretch provided can take up tolerances between positions of imager and reader instruments. In one example, the stretch can take up tolerances between positions of the junction between the rigid portion of tubing inside the IMC unit and the injector to an ionization source. The coupling tube may also be provided with a reduced inner diameter (ID) as compared to standard coupling components. A taper in the inner diameter (ID) can occur before the flow enters the stretchable coupling tube. Barbed ends may also be provided for securing the coupling tube into place.

公开(公告)号：US20250044571A1

公开(公告)日：2025-02-06

申请号：US18887633

申请日：2024-09-17

Applicant: Standard BioTools Canada Inc.

Inventor： Daaf Sandkuijl ,  Alexander V. Loboda ,  Adam Carew ,  Khashayar Askarpour

IPC: G02B21/24 ,  G01N1/04 ,  G01N33/543 ,  G02B21/00 ,  G02B21/26 ,  H01J49/00 ,  H01J49/10

Abstract: We describe in this application systems and methods for autofocusing in imaging mass spectrometry. The present application describes improvements over current IMS and IMC apparatus and methods through an autofocus component including a plurality of apertures in the autofocus system, such as a plurality of apertures arranged in 2 dimensions. As a plurality of apertures is used, the autofocus system provides redundancy in the event that measurement of focus on the sample from the illuminating radiation passed through one or more of the apertures fails so as to reduce the number of unsuccessful autofocus attempts.

公开(公告)号：US20230215714A1

公开(公告)日：2023-07-06

申请号：US17785887

申请日：2020-12-21

Applicant: Standard BioTools Canada Inc.

Inventor： Adam Carew ,  Daaf Sandkuijl ,  Alexander Loboda ,  Matthew Weel ,  Dmitry Bandura

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/04

CPC classification number: H01J49/0004 ,  H01J49/40 ,  H01J49/0463

Abstract: Described herein are systems and methods for imaging mass spectrometry, including imaging mass cytometry. Aspects of the subject application include apparatus and methods for imaging mass spectrometry (IMS) that improve speed of sample acquisition, signal sensitivity, and/or signal stability. Systems and methods described herein may minimize the transfer time and/or may minimize the spread of plumes of sample material ablated from a sample to be transferred to the components of the imaging mass spectrometer or mass cytometer that ionize and analyze the sample material.