公开(公告)号：US11141065B2

公开(公告)日：2021-10-12

申请号：US16355039

申请日：2019-03-15

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

IPC: A61B5/00

Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

公开(公告)号：US20220022741A1

公开(公告)日：2022-01-27

申请号：US17498102

申请日：2021-10-11

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

IPC: A61B3/00 ,  A61B3/10

Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured, showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray-like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

公开(公告)号：US20190209014A1

公开(公告)日：2019-07-11

申请号：US16355039

申请日：2019-03-15

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

IPC: A61B5/00

CPC classification number: A61B5/0082 ,  A61B5/0077 ,  A61B5/6821

Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

公开(公告)号：US11844586B2

公开(公告)日：2023-12-19

申请号：US17498102

申请日：2021-10-11

Applicant: TearScience, Inc.

Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

IPC: A61B5/00 ,  A61B3/00 ,  A61B3/10

CPC classification number: A61B5/0082 ,  A61B3/0008 ,  A61B3/101 ,  A61B5/0077 ,  A61B5/6821

Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured, showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray-like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

公开(公告)号：US10278587B2

公开(公告)日：2019-05-07

申请号：US14269646

申请日：2014-05-05

Applicant: TEARSCIENCE, INC.

Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich ,  John M. Jans

IPC: A61B5/00

Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

公开(公告)号：US20140330129A1

公开(公告)日：2014-11-06

申请号：US14269646

申请日：2014-05-05

Applicant: TEARSCIENCE, INC.

Inventor： Stephen M. Grenon ,  Donald R. Korb ,  Joshua Grenon ,  Scott Liddle ,  Steve Bacich

IPC: A61B5/00

CPC classification number: A61B5/0082 ,  A61B5/0077 ,  A61B5/6821

Abstract: Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

Abstract translation: 公开了眼睑照射系统和用于睑板腺分析成像睑板腺的方法。 在一个实施例中，患者的眼睑用红外（IR）光IR反照射。 捕获患者眼睑的透射照明图像，显示黑色轮廓区域中的睑板腺，而非腺体材料显示在浅色区域。 这提供了像X射线的睑板腺的高对比度图像。 可以分析睑板腺的盖反照明图像，以确定诊断患者眼睑中的睑板腺。 眼睑可以由构造成抓住并翻转眼睑的盖翻转装置反照，以对眼睑的内表面进行成像。 此外，还可以捕获睑板腺的IR表面记录图像并与睑板腺的反照明图像组合，以提供睑板腺的较高对比度图像。