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1.发明公开公开(公告)号：US20240150705A1
公开(公告)日：2024-05-09
申请号：US18542860
申请日：2023-12-18
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Nitin Nitin , Rewa Rai , Marluci Palazzolli da Silva Padilha
IPC: C12N1/04 , A61K35/745 , A61K35/747 , A61K36/61 , A61K36/77 , A61K36/87 , C12N1/20 , C12R1/23 , C12R1/245 , C12R1/25
CPC classification number: C12N1/04 , A61K35/745 , A61K35/747 , A61K36/61 , A61K36/77 , A61K36/87 , C12N1/205 , A61K2236/333 , C12R2001/23 , C12R2001/245 , C12R2001/25
Abstract: Vacuum infusion of plant extracts in live probiotic cells significantly enhances the viability of probiotics during in vitro gastrointestinal digestion with the retention of their metabolic and antagonistic activities. In-vivo results validate the significantly enhanced persistence and mucoadhesion of probiotic cells with infused plant extracts.
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公开(公告)号：US20220018836A1
公开(公告)日：2022-01-20
申请号：US17344202
申请日：2021-06-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Nitin Nitin , Mahmoudreza Ovissipour
IPC: G01N33/569 , G01N21/65 , G01J3/44 , G01J3/10
Abstract: Systems, surrogates, indicators and methods for rapid assessment of sanitation processes are provided. Non-living and non-toxic surrogates applied to a platform or encapsulated in a biological material mounted to a platform are exposed to a sanitation process to be evaluated. Responses to sanitation are measured and quantified using FTIR and chemometrics including principal component analysis (PCA), partial least squares regression (PLSR), loading plots and predictive models. An artificial leaf platform with one or more types of surrogates on one surface and an anchor such as an adhesive film on a second surface is described. Surrogate types include nucleic acid, phage, yeast and algae surrogates. Surrogates may also be attached directly or through a polymer to the platform surface. Surrogates may also be encapsulated or attached to the outside of a biological carrier such as a yeast cell that is free or coupled to the platform.
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公开(公告)号：US20200337304A1
公开(公告)日：2020-10-29
申请号：US16871831
申请日：2020-05-11
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Nitin Nitin , Kang Huang
Abstract: Rechargeable antimicrobial materials that can provide continuous sanitation of contact surfaces or liquids are provided that are based on functionalized sanitization particles that are either freestanding or coupled to a surface film. The sanitization particles have a carrier particle and one or more antimicrobial agents loaded into, adsorbed onto or bonded to each carrier particle. The antimicrobial agents may also be joined to a polymer or particulates of clay or zeolite that are coupled to the carrier. Sanitization particles may also be coupled directly to a film or through a chemical linker. The particles and films provide methods of enhanced inactivation of antibiotic resistant bacteria, inactivation and dissipation of biofilms, and the reduction or elimination of bacterial pathogens from surfaces, medical devices, on food or in food containers.
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Patent Agency Ranking
公开(公告)号：US20160088853A1
公开(公告)日：2016-03-31
申请号：US14784407
申请日：2014-04-16
Inventor： Rohan Vijay Tikekar , Nitin Nitin , Aachen Elsinghorst
CPC classification number: A23B7/015 , A23B7/01 , A23B7/10 , A23B7/154 , A23L3/28 , A23L3/3463 , A23L3/3499 , A23L3/3508 , A23L3/3526 , A23L3/3544 , A23V2002/00 , A61L2/00 , A61L2/088 , A61L9/00 , C02F1/32 , C02F1/725 , C02F2303/04 , C02F2305/023 , C02F2305/10
Abstract: The present invention is directed to a process of disinfecting produce, comprising the steps of associating the produce with one or more photosensitizers selected from the group consisting of gallic acid, fructose, riboflavin, sodium chlorophyllin and photo-porphyrin; and exposing the associated produce and one or more photosensitizers to UV radiation sufficient to cause the one or more photosensitizers to generate one or more free radicals. The produce may be fresh produce and may be selected from fresh vegetable and fruits. The present invention may also be used to treat waste water by adding at least one photosensitizer to waste water ant then expose the waste water to US radiation.
Abstract translation: 本发明涉及消毒产品的方法，包括以下步骤：将产物与选自没食子酸，果糖，核黄素，叶绿素钠和光卟啉的一种或多种光敏剂缔合。 并将相关产品和一种或多种光敏剂暴露于足以引起一种或多种光敏剂产生一种或多种自由基的紫外线辐射。 产品可以是新鲜农产品，可以选自新鲜蔬菜和水果。 本发明也可用于通过向废水蚂蚁中加入至少一种光敏剂来处理废水，然后将废水暴露于美国辐射。
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公开(公告)号：US09714288B2
公开(公告)日：2017-07-25
申请号：US14871862
申请日：2015-09-30
Inventor： Michael Oestergaard , Punit P. Seth , Shuling Guo , Noriko Satake , Nitin Nitin , Joseph M. Tuscano
IPC: A61K31/70 , C07H21/02 , C07H21/04 , C07K16/28 , A61K31/475 , A61K31/704 , A61K47/48 , A61K31/713 , A61K31/00 , C12N15/113 , C12N5/00
CPC classification number: C07K16/2803 , A61K31/00 , A61K31/475 , A61K31/704 , A61K31/713 , A61K47/484 , A61K47/4863 , A61K47/6807 , A61K47/6867 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346
Abstract: The present disclosure provides compounds comprising modified oligonucleotides and anti-CD22 antibodies. Certain such modified oligonucleotides conjugated to anti-CD22 antibodies are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
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公开(公告)号：US10509036B2
公开(公告)日：2019-12-17
申请号：US15586594
申请日：2017-05-04
Applicant: The Regents of the University of California
Inventor： Noriko Satake , Nitin Nitin
IPC: G01N33/574 , G01N33/50 , G01N33/58
Abstract: Provided herein are methods for selecting/identifying and/or isolating cancer stem cells from a biological sample or a cell culture sample using a fluorescent glucose analog. Also provided herein are methods for selecting/identifying and/or isolating leukemia stem cells and subpopulations thereof. The present invention is based, in part, on the discovery that cancer stem cells can be selected/identified based upon a lower level of fluorescence of the fluorescent glucose analog compared to non-cancer stem cells and that specific genes are differentially expressed in leukemia stem cells compared to non-leukemia stem cells.
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公开(公告)号：US20180011100A1
公开(公告)日：2018-01-11
申请号：US15586594
申请日：2017-05-04
Applicant: The Regents of the University of California
Inventor： Noriko Satake , Nitin Nitin
IPC: G01N33/574
CPC classification number: G01N33/57426 , G01N33/5005 , G01N33/574 , G01N33/57407 , G01N33/582
Abstract: Provided herein are methods for selecting/identifying and/or isolating cancer stem cells from a biological sample or a cell culture sample using a fluorescent glucose analog. Also provided herein are methods for selecting/identifying and/or isolating leukemia stem cells and subpopulations thereof. The present invention is based, in part, on the discovery that cancer stem cells can be selected/identified based upon a lower level of fluorescence of the fluorescent glucose analog compared to non-cancer stem cells and that specific genes are differentially expressed in leukemia stem cells compared to non-leukemia stem cells.
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公开(公告)号：US20160090598A1
公开(公告)日：2016-03-31
申请号：US14871862
申请日：2015-09-30
Inventor： Michael Oestergaard , Punit P. Seth , Shuling Guo , Noriko Satake , Nitin Nitin , Joseph M. Tuscano
IPC: C12N15/113 , C07K16/28 , A61K47/48 , A61K31/713 , A61K31/475 , A61K31/704
CPC classification number: C07K16/2803 , A61K31/00 , A61K31/475 , A61K31/704 , A61K31/713 , A61K47/484 , A61K47/4863 , A61K47/6807 , A61K47/6867 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346
Abstract: The present disclosure provides compounds comprising modified oligonucleotides and anti-CD22 antibodies. Certain such modified oligonucleotides conjugated to anti-CD22 antibodies are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
Abstract translation: 本公开提供包含修饰的寡核苷酸和抗CD22抗体的化合物。 与抗CD22抗体缀合的某些这样的修饰的寡核苷酸可用于与互补核酸杂交，包括但不限于细胞中的核酸。 在某些实施方案中，杂交导致细胞中靶核酸的活性或表达的调节。
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