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公开(公告)号:US20150313471A1
公开(公告)日:2015-11-05
申请号:US14650524
申请日:2014-01-20
Inventor: Kishan DHOLAKIA , Praveen Cheriyan ASHOK
Abstract: An optical apparatus comprising a disposable non-magnetic optical fibre probe for coupling light into a sample and receiving light from the sample for performing Raman spectroscopy, and a non-magnetic optical extension releasably connected to the disposable non-magnetic optical probe for transmitting light into the disposable non-magnetic optical probe and receiving light from the disposable non-magnetic optical probe.
Abstract translation: 一种光学装置,包括一次性非磁性光纤探针,用于将光耦合到样品中并且接收来自用于进行拉曼光谱的样品的光,以及可释放地连接到一次性非磁性光学探针的非磁性光学延伸件,用于将光传输到 一次性非磁性光学探针和从一次性非磁性光学探针接收光。
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公开(公告)号:US20200041778A1
公开(公告)日:2020-02-06
申请号:US16339850
申请日:2017-10-05
Inventor: Kishan DHOLAKIA , Zhengyi YANG
Abstract: A light sheet imaging system comprises an acoustic trapping arrangement for forming an acoustic trap using one or more acoustic beams and an optical system for light sheet imaging a sample positioned in the acoustic trap. A light sheet imaging method comprises forming an acoustic trap using one or more acoustic beams and light sheet imaging a sample positioned in the acoustic trap. The system and/or the method may be used for light sheet microscopy using acoustic trapping for the contactless confinement of a sample to be imaged such as a particle, a colloid, a cell, a conglomerate of cells (e.g. a cell biopsy), an embryo, a larva or an organism such as a complex organism or a plurality of such samples.
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公开(公告)号:US20180266890A1
公开(公告)日:2018-09-20
申请号:US15977596
申请日:2018-05-11
Inventor: Kishan DHOLAKIA , Michael MAZILU , Klaus METZGER
CPC classification number: G01J9/0246 , G01J1/4257 , G01J3/0205 , G01J4/00 , G01J2001/0481 , G01J2009/0257
Abstract: An optical system comprising a randomizer that has a plurality of randomly positioned scatterers for scattering and thereby randomizing light to generate a speckle pattern and a detector for detecting the speckle pattern to determine at least one property of the light and/or change in at least one property of the light.
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公开(公告)号:US20180101000A1
公开(公告)日:2018-04-12
申请号:US15566889
申请日:2016-05-09
Inventor: Zhengyi YANG , Kishan DHOLAKIA
Abstract: An optical system comprising trapping optics for forming an optical trap using counter propagating beams of light and light sheet imaging optics for light sheet imaging a particle, for example a cell, that is positioned in the optical trap, wherein the wavelength of the counter propagating beams of light and the wavelength of the light used for light sheet imaging are non-interfering.
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公开(公告)号:US20190361214A1
公开(公告)日:2019-11-28
申请号:US16433429
申请日:2019-06-06
Inventor: Michael MAZILU , Tom VETTENBURG , Kishan DHOLAKIA , Miguel PRECIADO , Zhengyi YANG
Abstract: An optical system for generating an Airy beam light sheet comprising an optical arrangement for generating a Gaussian beam, and an optical element for converting the Gaussian beam into an Airy beam light sheet, wherein a single optical element is provided for converting the Gaussian beam into an Airy beam light sheet.
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公开(公告)号:US20170199363A1
公开(公告)日:2017-07-13
申请号:US15326073
申请日:2015-07-29
Inventor: Michael MAZILU , Tom VETTENBURG , Kishan DHOLAKIA , Miguel PRECIADO , Zhengyi YANG
CPC classification number: G02B21/06 , G02B21/0032 , G02B21/0076 , G02B26/02 , G02B26/06 , G02B27/0927 , G02B27/0944 , G02B27/0966 , G02B27/0988 , G02B27/30
Abstract: An optical system for generating an Airy beam light sheet comprising an optical arrangement for generating a Gaussian beam, and an optical element for converting the Gaussian beam into an Airy beam light sheet, wherein a single optical element is provided for converting the Gaussian beam into an Airy beam light sheet.
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公开(公告)号:US20160258817A1
公开(公告)日:2016-09-08
申请号:US15032563
申请日:2014-10-29
Inventor: Kishan DHOLAKIA , Michael MAZILU , Klaus METZGER
CPC classification number: G01J9/0246 , G01J1/4257 , G01J3/0205 , G01J4/00 , G01J2001/0481 , G01J2009/0257
Abstract: An optical system comprising a randomizer that has a plurality of randomly positioned scatterers for scattering and thereby randomizing light to generate a speckle pattern and a detector for detecting the speckle pattern to determine at least one property of the light and/or change in at least one property of the light.
Abstract translation: 一种光学系统,包括随机化器,其具有多个随机设置的用于散射的散射体,从而使光随机化以产生散斑图案;以及检测器,用于检测斑点图案,以确定至少一个光的至少一个性质和/或变化 光的属性。
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公开(公告)号:US20210033837A1
公开(公告)日:2021-02-04
申请号:US16622542
申请日:2018-06-15
Inventor: Kishan DHOLAKIA
Abstract: A light sheet imaging system, such as a light sheet microscope, comprises an illumination arrangement for generating a light sheet for three-photon excitation of a fluorescent sample, and a fluorescence collection arrangement for collecting fluorescence generated in the sample as a result of three-photon excitation by the light sheet. The light sheet may be a non-diffractive, propagation-invariant light sheet. The light sheet may be formed from and/or comprise a Bessel beam. A method of light sheet imaging comprises using a light sheet for three-photon excitation of a fluorescent sample, and collecting fluorescence generated in the sample as a result of three-photon excitation of the sample by the light sheet. Such a method may be used for light sheet microscopy.
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公开(公告)号:US20190242752A1
公开(公告)日:2019-08-08
申请号:US16333192
申请日:2017-09-13
Inventor: Kishan DHOLAKIA , Mingzhou CHEN
CPC classification number: G01J3/4412 , G01J3/0218 , G01J3/0262 , G01J3/0272 , G01J3/44 , G01J3/4406 , G01N21/65 , G01N2021/651
Abstract: A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer, and an optical system for coupling light from the optical source to a sample and for coupling light from the sample to the spectrometer and a further spectrometer. A Raman system for use in performing Raman spectroscopy on a sample, comprises an optical source, a spectrometer and an optical system for coupling light from the optical source and a further optical source to a sample and for coupling light from the sample to the spectrometer. The optical system may be configured for coupling light from the optical source and the further optical source to the sample and for coupling light from the sample to the spectrometer and the further spectrometer. The Raman system may be portable and/or may be configured to be transported and/or carried and/or may be handheld.
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公开(公告)号:US20180120232A1
公开(公告)日:2018-05-03
申请号:US15561878
申请日:2016-03-01
Inventor: Derek CRAIG , Kishan DHOLAKIA , Michael MAZILU
CPC classification number: G01N21/65 , B01L3/502715 , G01N33/15 , G01N2021/6419
Abstract: A method for detecting or identifying an analyte, the method comprising: applying an analyte in fluid, for example a drug, to a paper microfluidic device; exciting Raman scattering in the analyte in the paper microfluidic device at a multiple different wavelengths; capturing a signal at each wavelength; and analyzing the captured signal at each wavelength to identify a Raman signal associated with the analyte.
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