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公开(公告)号：US11534460B2
公开(公告)日：2022-12-27
申请号：US15573379
申请日：2016-05-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Li Zhang , Paulina Achita , Jong Lee , Dalam Ly , Dzana Dervovic
IPC: A61K35/17 , C12N5/0783 , A61P35/00
Abstract: There is provided herein a method for expanding human CD4-CD8- regulatory T cells (DN Tregs) from a population of cells comprising DN Tregs, comprising: culturing the population of cells with artificial antigen presenting cells (APCs), preferably the DN Tregs are αβ-TCR-CD56- or alternatively γ8-TCR+.
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