公开(公告)号：US20250067599A1

公开(公告)日：2025-02-27

申请号：US18721164

申请日：2022-12-19

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Ashwin PARTHASARATHY ,  Sadhu MOKA ,  Abdul Mohaimen SAFI

IPC: G01J3/433 ,  A61B5/026 ,  A61B5/145 ,  A61B5/1455 ,  G01J1/44 ,  G01J3/02 ,  G01J3/44

Abstract: Systems, methods, and apparatus for frequency domain diffuse correlation spectroscopy are provided. In some embodiments, the system comprises: an intensity modulated coherent light source; a photon counting detector; at least one hardware processor that is programmed to: cause the light source to emit light at a plurality of different intensity modulation frequencies toward a tissue sample; detect, for each of the plurality of different modulation frequencies, photon counts over a predetermined period of time; determine, for each of the plurality of modulation frequencies, a normalized intensity auto-correlation function; estimate a plurality of properties of the tissue sample using the plurality of intensity auto-correlation functions; and output at least one of the plurality of properties.

公开(公告)号：US20230363657A1

公开(公告)日：2023-11-16

申请号：US18029649

申请日：2021-09-28

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Abdul Mohaimen SAFI ,  Ashwin Bharadwaj PARTHASARATHY ,  Sadhu MOKA

IPC: A61B5/026 ,  A61B5/00

CPC classification number: A61B5/0261 ,  A61B5/0075

Abstract: A system configured to perform the DCS-type measurements with the use of low-coherence continuous-wave (CW) light source at levels of light intensities that are substantially lower and with pathlengths through the tissue that are substantially longer than those afforded by the use of conventional methods. The method includes utilizing the optical detection system to producing signals representing interference between the portion of CW light arriving through reference arm of interferometer and the sample CW light potion that has traversed the sample arm including different paths through the target tissue while switching between first and second of said different paths only by adjusting a delay in the delay line. The spatial resolution of different pathlengths of sample light through tissue is defined by coherence length of CW light.