公开(公告)号：US20250136942A1

公开(公告)日：2025-05-01

申请号：US18932104

申请日：2024-10-30

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Zhipeng LU ,  Minjie ZHANG ,  Kongpan LI ,  Jianhui BAI

IPC: C12N5/077 ,  A61K35/34 ,  C12N9/22 ,  C12N15/113

Abstract: The disclosure provides methods of promoting stem cell differentiation into mesoderm and endoderm cell lineages comprising, for example, contacting a stem cell with an agent that reduces or eliminates gene activity of one or more endogenous small nuclear ribonucleic acid (snoRNA) molecules, wherein the snoRNA molecules comprise SNORD97 and/or SNORD133. Also provided are isolated cardiomyocytes and compositions of the same, wherein the cardiomyocytes are produced using a method described herein.

公开(公告)号：US20240166683A1

公开(公告)日：2024-05-23

申请号：US18503951

申请日：2023-11-07

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  RADBOUD UNIVERSITY NIJMEGEN

Inventor： Zhipeng LU ,  Willem A. VELEMA ,  Ryan VAN DAMME

IPC: C07H21/02 ,  C12N15/11

CPC classification number: C07H21/02 ,  C12N15/111 ,  C12N2310/351 ,  C12N2320/51

Abstract: Reversible Spatial 2′ Hydroxyl Acylation Reversible Crosslinking (SHARC) agents and methods of using the same to determine spatial distance between nucleotides in a ribonucleic acid (RNA) molecule.