公开(公告)号：US20150092190A1

公开(公告)日：2015-04-02

申请号：US14499741

申请日：2014-09-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： John Curtis Wright ,  Erin Selene Boyle

IPC: G01N21/65 ,  G01J3/45

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/44 ,  G01N2201/06113 ,  G01N2201/0697

Abstract: Methods of obtaining a multidimensional image of a sample are provided comprising (a) directing a first coherent light pulse having a first frequency ω1 and a first wave vector k1 at a first location in the sample, (b) directing a second coherent light pulse having a second frequency ω2 and a second wave vector k2 at the first location, (c) directing a third coherent light pulse having a third frequency ω3 and a third wave vector k3 at the first location and (d) detecting a coherent output signal having a fourth frequency ω4 and a fourth wave vector k4. At least two, but optionally all three, of the coherent light pulses each excite a different transition to a discrete quantum state (e.g., transitions to vibrational states or to electronic states) of a molecule or molecular functionality in the sample. Steps (a)-(d) are repeated at a sufficient number of other locations in the sample to provide the multidimensional image.

Abstract translation: 提供了获得样本的多维图像的方法，包括：（a）在样本中的第一位置处引导具有第一频率ω1和第一波矢量k1的第一相干光脉冲，（b）引导具有 在第一位置处的第二频率ω2和第二波矢量k2，（c）在第一位置处引导具有第三频率ω3和第三波矢量k3的第三相干光脉冲，以及（d）检测具有 第四频率ω4和第四波矢量k4。 每个相干光脉冲中的至少两个，但可选地，全部三个激发不同的跃迁到样品中分子或分子功能的离散量子态（例如，转变到振动状态或电子状态）。 在样本中的足够数量的其他位置重复步骤（a） - （d）以提供多维图像。

公开(公告)号：US09267893B2

公开(公告)日：2016-02-23

申请号：US14499741

申请日：2014-09-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： John Curtis Wright ,  Erin Selene Boyle

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/44 ,  G01N2201/06113 ,  G01N2201/0697

Abstract: Methods of obtaining a multidimensional image of a sample are provided comprising (a) directing a first coherent light pulse having a first frequency ω1 and a first wave vector k1 at a first location in the sample, (b) directing a second coherent light pulse having a second frequency ω2 and a second wave vector k2 at the first location, (c) directing a third coherent light pulse having a third frequency ω3 and a third wave vector k3 at the first location and (d) detecting a coherent output signal having a fourth frequency ω4 and a fourth wave vector k4. At least two, but optionally all three, of the coherent light pulses each excite a different transition to a discrete quantum state (e.g., transitions to vibrational states or to electronic states) of a molecule or molecular functionality in the sample. Steps (a)-(d) are repeated at a sufficient number of other locations in the sample to provide the multidimensional image.

Abstract translation: 提供了获得样本的多维图像的方法，包括：（a）在样本中的第一位置处引导具有第一频率ω1和第一波矢量k1的第一相干光脉冲，（b）引导具有 在第一位置处的第二频率ω2和第二波矢量k2，（c）在第一位置处引导具有第三频率ω3和第三波矢量k3的第三相干光脉冲，以及（d）检测具有 第四频率ω4和第四波矢量k4。 每个相干光脉冲中的至少两个，但可选地，全部三个激发不同的跃迁到样品中分子或分子功能的离散量子态（例如，转变到振动状态或电子状态）。 在样本中的足够数量的其他位置重复步骤（a） - （d）以提供多维图像。