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公开(公告)号：KR1020090088236A
公开(公告)日：2009-08-19
申请号：KR1020080013657
申请日：2008-02-14
Applicant: 재단법인서울대학교산학협력재단
Abstract: A bio marker related to CLA (conjugated linoleic acid) synthesis is provided to select an animal which produces milk having high content of CLA and minimize selection process. A bio marker related to CLA biosynthesis comprises a protein of which expression is respectively increases in a glandula mammaria having high CLA expression activity than that having low CLA expression activity. A diagnostic agent for selecting a lactating animal having high content of CLA comprises a biomarker protein or antigen which specifically binds to immunogen fragment.
Abstract translation: 提供了与CLA（共轭亚油酸）合成相关的生物标记物，以选择产生CLA含量高的乳的动物，并使选择过程最小化。 与CLA生物合成相关的生物标志物包含与具有低CLA表达活性的CLA相比具有高CLA表达活性的腺体乳腺中分别增加的蛋白质。 用于选择CLA含量高的哺乳动物的诊断剂包括特异性结合免疫原片段的生物标记蛋白或抗原。
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公开(公告)号：KR1020090088225A
公开(公告)日：2009-08-19
申请号：KR1020080013643
申请日：2008-02-14
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: G01N33/577 , G01N33/6812
Abstract: A bio marker protein related to the time of muscle development and fat development is provided to settle the production technology of Korean beef (Hanwoo) having high quality and minimize the selection process. A bio marker for selecting Korean beef (Hanwoo) comprises a villin 2 protein having the sequence number 1 of which expression is increased in sirloin of muscle development period than that of fat development period. An agent for selecting Korean beef (Hanwoo) having high quality comprises a bio marker protein having villin 2 protein or an antibody which specifically binds to an immunogen fragment as an active ingredient. The antibody is monoclonal antibody.
Abstract translation: 提供与肌肉发育和脂肪发育时间相关的生物标记蛋白，以确定高品质的韩国牛肉（Hanwoo）的生产技术，并尽可能减少选择过程。 用于选择韩国牛肉（Hanwoo）的生物标记物包括在肌肉发育期的牛腩中表达增加的序列号1的绒毛蛋白2蛋白质比脂肪发育期的蛋白质。 用于选择具有高品质的韩国牛肉（Hanwoo）的药剂包括具有绒毛蛋白2蛋白的生物标记蛋白或特异性结合免疫原片段作为活性成分的抗体。 抗体是单克隆抗体。
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3.发明公开피에이치 감응성과 점막점착성을 갖는 유드라지트로 코팅된단백질 경구투여용 키토산미립자 및 그 제조방법 无效用于通过敏感和不饱和脂肪族螺旋体衍生物涂覆的口服蛋白质药物递送的壳聚糖微球及其制备方法
公开(公告)号：KR1020090039513A
公开(公告)日：2009-04-22
申请号：KR1020070105205
申请日：2007-10-18
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: C08B37/003 , A61K9/0053 , A61K9/167 , A61K47/36
Abstract: A chitosan particle coated with thiolated eudragit, in which the BSA(Bovine Serum Albumin) is soaked, is provide to use as a delivery agent of a drug by oral administration. A manufacturing method of a chitosan particulate for a protein oral administration coated with eudragit having a pH sensitivity and mucous adhesive property comprises: a step of sonicating and centrifuging the chitosan solution to obtain chitosan particle; a step of adding BSA to the chiotsan particle, suspending to distribute the chitosan particle, and stirring at 35-40°C for 12-24 hours to soak the BSA into chitosan particle; and a step of adding the thiolated eudragit solution to the BSA-soaked chitosan particle, stirring and centrifuging to obtain the chitosan particle coated with BSA-dipped thiolated eudragit. The addition rate of the thiolated eudragit solution to the BSA-dipped chitosan particle is 1:1-1:4.
Abstract translation: 将BSA（牛血清白蛋白）浸泡的硫蛋白包被的壳聚糖颗粒通过口服给药用作药物的递送剂。 用于具有pH敏感性和粘性粘合性质的用于蛋白质口服给药的壳聚糖颗粒的制造方法包括：超声处理和离心壳聚糖溶液以获得壳聚糖颗粒的步骤; 将BSA加入到悬浮颗粒中，悬浮以分散壳聚糖颗粒，并在35-40℃下搅拌12-24小时以将BSA浸泡到壳聚糖颗粒中; 将硫醇化的eudragit溶液加入到BSA-浸泡的壳聚糖颗粒中，搅拌和离心以获得涂布有BSA-浸渍的硫苷酸脱乙酰壳多糖的壳聚糖颗粒的步骤。 硫苷酸脱乙酰壳多糖溶液对BSA-浸渍壳聚糖颗粒的添加速率为1:1-1:4。
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4.发明公开서머스 필리포미스(Ｔｈｅｒｍｕｓ ｆｉｌｉｆｏｒｍｉｓ)Ｗａｉ 33 Ａ１ 유래 신규의 내열성 베타-글리코시다제,ｔｆｉ β-ｇｌｙ 有权可从THERMUS FILIFORMIS WAI 33 A1中得到的热稳定β-谷氨酰胺酶TFIβ-GLY
公开(公告)号：KR1020030094518A
公开(公告)日：2003-12-18
申请号：KR1020020026801
申请日：2002-05-15
Applicant: 재단법인서울대학교산학협력재단
IPC: C12N15/56
Abstract: PURPOSE: Thermostable beta-glycosidase tfi β-gly derived from Thermus filiformis Wai 33 A1 is provided. The enzyme is easily purified by the simple heat treatment, maintains its activity at pH 7.0 and 70 deg. C for 70 hours or more, and shows maximum enzyme activity at pH 5.0-6.0 and 80 to 90 deg. C. CONSTITUTION: A thermostable beta-glycosidase tfi β-gly derived from Thermus filiformis Wai 33 A1 has the amino acid sequence of SEQ ID NO: 6, wherein the thermostable beta-glycosidase tfi β-gly has improved lactose degrading activity; and the thermostable beta-glycosidase tfi β-gly is expressed from the recombinant Escherichia coli containing a gene encoding the thermostable beta-glycosidase tfi β-gly. The gene encoding the amino acid sequence of SEQ ID NO: 6 has the nucleotide sequence of SEQ ID NO: 5.
Abstract translation: 目的：提供源自Thermus filiformis Wai 33 A1的热稳定性β-糖苷酶tfiβ-gly。 酶易于通过简单的热处理纯化，其活性保持在pH 7.0和70度。 70小时以上，并且在pH 5.0-6.0和80至90度下显示出最大的酶活性。 C.构成：源自Thermus filiformis Wai 33A1的热稳定性β-糖苷酶tfiβ-gly具有SEQ ID NO：6的氨基酸序列，其中，所述耐热β-糖苷酶tfiβ-gly具有改善的乳糖降解活性; 并且由含有编码热稳定性β-糖苷酶tfiβ-gly的基因的重组大肠杆菌表达热稳定性β-糖苷酶tfiβ-gly。 编码SEQ ID NO：6的氨基酸序列的基因具有SEQ ID NO：5的核苷酸序列。
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5.发明公开서머스(Ｔｈｅｒｍｕｓ ｓｐ.) ＩＢ-21 유래 신규의내열성 베타-갈락토시다제, ｔｉｂ β-ｇａｌ 失效来自THERMUS SP的新型可热降解的β-GLYCOSIDASE TIBβ-GAL IB-21
公开(公告)号：KR1020030088964A
公开(公告)日：2003-11-21
申请号：KR1020020026802
申请日：2002-05-15
Applicant: 재단법인서울대학교산학협력재단
IPC: C12N15/56
CPC classification number: C12N9/2471 , C12N15/70 , C12Y302/01023
Abstract: PURPOSE: Novel thermostable beta-glycosidase tib β-gal derived from Thermus sp. IB-21 is provided. The enzyme is easily purified because the protein derived from the mesophilic host cell can be easily removed by the simple heat treatment. CONSTITUTION: Novel thermostable beta-glycosidase tib β-gal derived from Thermus sp. IB-21 has the amino acid sequence of SEQ ID NO: 12, wherein the thermostable beta-glycosidase tib β-gal can maintain its activity at pH 7.0 and 70 deg. C for 70 hours or more, and has maximum enzyme activity at pH 5.0 to 6.0 and 80 to 90 deg. C. A gene encoding the amino acid sequence of SEQ ID NO: 12 has the nucleotide sequence of SEQ ID NO: 11. The thermostable beta-glycosidase tib β-gal is combined together in the form of homo-dimer.
Abstract translation: 目的：来自Thermus sp。的新型热稳定性β-糖苷酶tibβ-gal 提供IB-21。 该酶易于纯化，因为通过简单的热处理可以容易地除去源自嗜温宿主细胞的蛋白质。 构成：来自Thermus sp。的新型热稳定性β-糖苷酶tibβ-gal IB-21具有SEQ ID NO：12的氨基酸序列，其中热稳定的β-糖苷酶tibβ-gal可以在pH 7.0和70度维持其活性。 70℃以上，并且在pH 5.0〜6.0和80〜90℃下具有最大的酶活性。 C.编码SEQ ID NO：12的氨基酸序列的基因具有SEQ ID NO：11的核苷酸序列。将热稳定性β-糖苷酶tibβ-gal以同二聚体的形式组合在一起。
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Patent Agency Ranking
公开(公告)号：KR100967588B1
公开(公告)日：2010-07-05
申请号：KR1020080013643
申请日：2008-02-14
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 고급육 생산을 위한 근육발달시기 및 지방발달시기와 관련된 바이오 마커 단백질 및 이를 이용하여 우수한 경제형질을 지닌 한우를 선발하는 방법에 관한 것이다.
본 발명에 따르면, 단백질 수준에서 한우의 근육발달시기 및 지방발달시기와 관련된 바이오 마커 단백질을 프로테옴분석 기술을 이용하여 선발한 후 이를 활용하여 새로운 개념의 고급육 생산기술을 정착시킬 수 있다. 또한, 고비용의 표현형 위주의 능력검정작업을 최소화함과 동시에 성장 초기에 고급육 선별에 활용하여 형질이 우수한 한우를 확보할 수 있다.
한우, 근육발달시기, 지방발달시기, 바이오 마커, 프로테옴, villin 2-
公开(公告)号：KR100905084B1
公开(公告)日：2009-06-30
申请号：KR1020070068172
申请日：2007-07-06
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 항암용 불포화 고급지방산 유도체 및 그 제조 방법에 관한 것으로, 용매나 촉매를 쓰지 않는 온도 처리의 간단한 방법으로 불포화 고급지방산에 폴리에틸렌글리콜 또는 폴리에틸렌글리콜과 폴리프로필렌글리콜의 공중합체를 결합시켜 항암활성이 향상된 불포화 고급지방산 유도체를 제조하는 방법 및 이로부터 제조된 항암용 불포화 고급지방산 유도체를 제공할 수 있는 매우 뛰어난 효과가 있다.
불포화 고급지방산, CLA, 공액 리놀레산, 폴리에틸렌글리콜, 폴리프로필렌글리콜, 공중합체, 항암-
公开(公告)号：KR1020090004173A
公开(公告)日：2009-01-12
申请号：KR1020070068172
申请日：2007-07-06
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K31/23 , A61K47/6925 , B82Y5/00 , B82Y40/00
Abstract: An unsaturated high molecular weight fatty acid derivative, a method for preparing the derivative, and an anticancer composition containing the derivative are provided to improve the anticancer activity remarkably. An unsaturated high molecular weight fatty acid derivative is represented by the formula 1, wherein R is a C18-C22 alkenyl group; n is an integer of 1-400; m is an integer of 0-200; and l is an integer of 0-400. Also the unsaturated high molecular weight fatty acid derivative is represented by the formula 2, wherein R is a C18-C22 alkenyl group; and X, X', X'', X''', Y, Y', Y'' and Y''' are an integer of 1-400.
Abstract translation: 提供不饱和高分子量脂肪酸衍生物，制备该衍生物的方法和含有该衍生物的抗癌组合物，以显着提高抗癌活性。 不饱和高分子量脂肪酸衍生物由式1表示，其中R是C 18 -C 22烯基; n为1-400的整数; m是0-200的整数; l为0-400的整数。 此外，不饱和高分子量脂肪酸衍生物由式2表示，其中R是C 18 -C 22烯基; X，X'，X“，X”'，Y，Y'，Y“和Y”'为1-400的整数。
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公开(公告)号：KR100856938B1
公开(公告)日：2008-09-05
申请号：KR1020060039032
申请日：2006-04-28
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 불포화 고급지방산의 페길화 방법에 관한 것으로, 보다 구체적으로는 용매나 촉매를 쓰지 않는 온도 처리의 간단한 방법으로 불포화 고급지방산을 PEGylation 시킬 수 있고, 페길화 고급지방산에 의해 반응 전 불포화 고급지방산이 갖는 고유한 성질은 유지시키면서 세포에 대한 독성을 줄였으며, 제조된 페길화 고급지방산은 core-shell 특성을 가진 나노입자를 형성함으로써 약물의 방출 조절과 안정성을 높일 수 있으므로 페길화에 의해 안정화되고 반추위 미생물들에 의한 이성화 방지가 가능한 신규한 페길화 고급지방산을 제공할 수 있는 매우 뛰어난 효과가 있다.
불포화 고급지방산, CLA, 공액 리놀레산, 페길화, 지방산, 반추위, 폴리에틸렌글리콜-
10.发明公开
公开(公告)号：KR1020080024016A
公开(公告)日：2008-03-17
申请号：KR1020060088277
申请日：2006-09-12
Applicant: 재단법인서울대학교산학협력재단
Abstract: A novel gene carrier is provided to reduce cytotoxicity and biodegradability, and improve gene deliver efficiency and complex-forming ability with DNA by using biodegradable polyesteramine based on polycaprolactone diacrylate and polyethyleneimine. A method for preparing a novel gene carrier comprises the steps of: independently dissolving polyethyleneimine and polycaprolactone diacrylate in anhydrous methyl alcohol; mixing the dissolved polyethyleneimine and polycaprolactone diacrylate; sealing the mixture with a solvent-resistant cover and reacting them at 40 deg. C for 24 hours; and subjecting the reaction product to dialysis with a membrane of 6,000-8,000 dalton at 4 deg. C for 24 hours. Further, a mol rate of the polycaprolactone diacrylate and the polyethyleneimine is 1:1 to 4.
Abstract translation: 提供了一种新的基因载体，通过使用基于聚己内酯二丙烯酸酯和聚乙烯亚胺的可生物降解的聚酯胺，降低细胞毒性和生物降解性，并提高DNA的基因传递效率和复合形成能力。 制备新基因载体的方法包括以下步骤：独立地将聚乙烯亚胺和聚己内酯二丙烯酸酯溶解在无水甲醇中; 混合溶解的聚乙烯亚胺和聚己内酯二丙烯酸酯; 用耐溶剂的盖子密封混合物，并将它们在40℃下反应。 C 24小时; 并用4,000-8,000道尔顿的膜在4℃下对该反应产物进行透析。 C 24小时。 此外，聚己内酯二丙烯酸酯和聚乙烯亚胺的摩尔比为1:1〜4。
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