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公开(公告)号：KR1020090128634A
公开(公告)日：2009-12-16
申请号：KR1020080054477
申请日：2008-06-11
Applicant: 서울시립대학교 산학협력단 , 재단법인서울대학교산학협력재단 , (주)한미글로벌건축사사무소 , 단국대학교 산학협력단 , (주) 희림종합건축사사무소 , 한국건설기술연구원
Abstract: PURPOSE: A model for estimating the design construction cost of a public apartment based on CBR is provided to perform the calculation of construction cost based on the amount of materials, thereby improving the accuracy and reliability of the estimation. CONSTITUTION: A design phase to predict is set up(S20). Parts to predict are selected(S50). The basic information of an apartment complex and the building information of each building are inputted(S60). An index according to the input information is compared in a database(S70). A similar case is selected by a CBR(Case based Reasoning) algorithm(S80). By the comparison with the selected similar case, a similar case is selected(S90,S100). The manpower/material quantity of the selected similar case is extracted from a material amount database(S110). Cost about the corrected material amount is extracted from the expense database of the database(S130). Direct construction cost is calculated(S150).
Abstract translation: 目的：提供基于CBR的公屋设计施工成本估算模型，根据材料量进行施工成本计算，提高估算的准确性和可靠性。 构成：建立设计阶段（S20）。 选择要预测的部分（S50）。 输入公寓的基本信息和各建筑物的建筑物信息（S60）。 在数据库中比较根据输入信息的索引（S70）。 类似的情况由CBR（基于案例的推理）算法（S80）选择。 通过与所选择的类似情况的比较，选择类似的情况（S90，S100）。 从材料量数据库中提取所选择的类似情况的人力/物料数量（S110）。 从数据库的费用数据库中提取关于校正材料量的成本（S130）。 计算直接建设成本（S150）。
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Patent Agency Ranking2.发明公开알파-일레오스테아르산을 포함하는 유방암 치료용 조성물및 이를 이용한 피피에이알γ 활성 조절에 의한 질환의치료방법 无效用于治疗包含ALPHA-ELEOSTEACIC酸的乳腺癌的组合物和通过使用其调节PPARγ活性来治疗疾病的方法
公开(公告)号：KR1020090012520A
公开(公告)日：2009-02-04
申请号：KR1020070076422
申请日：2007-07-30
Applicant: 재단법인서울대학교산학협력재단 , 주식회사 리포젠
Abstract: A composition for treatment of breast cancer is provided to investigate anti-cancer capability and mechanism in MCF-7 breast cancer cell using alpha-eleostearic acid. A composition for treatment of breast cancer includes alpha-eleostearic acid to active ingredient. A remedial method of disease at cancer cell line includes a step of processing the alpha-eleostearic acid of a therapeutically effective amount to the cancer cell line and prevents, suppresses or improves pathology or symptom of diseases by adjustment of PPAR gamma activity or phosphorylation of ERK1/2.
Abstract translation: 提供了一种用于治疗乳腺癌的组合物，用于研究使用α-蒿酸的MCF-7乳腺癌细胞的抗癌能力和机制。 用于治疗乳腺癌的组合物包括对活性成分的α-蒿酸。 在癌细胞系疾病的补救方法包括将治疗有效量的α-蒿酸处理至癌细胞系的步骤，通过调整PPARγ活性或ERK1磷酸化来预防，抑制或改善疾病的病理学或症状 / 2。
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公开(公告)号：KR100905084B1
公开(公告)日：2009-06-30
申请号：KR1020070068172
申请日：2007-07-06
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 항암용 불포화 고급지방산 유도체 및 그 제조 방법에 관한 것으로, 용매나 촉매를 쓰지 않는 온도 처리의 간단한 방법으로 불포화 고급지방산에 폴리에틸렌글리콜 또는 폴리에틸렌글리콜과 폴리프로필렌글리콜의 공중합체를 결합시켜 항암활성이 향상된 불포화 고급지방산 유도체를 제조하는 방법 및 이로부터 제조된 항암용 불포화 고급지방산 유도체를 제공할 수 있는 매우 뛰어난 효과가 있다.
불포화 고급지방산, CLA, 공액 리놀레산, 폴리에틸렌글리콜, 폴리프로필렌글리콜, 공중합체, 항암-
公开(公告)号：KR1020090004173A
公开(公告)日：2009-01-12
申请号：KR1020070068172
申请日：2007-07-06
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K31/23 , A61K47/6925 , B82Y5/00 , B82Y40/00
Abstract: An unsaturated high molecular weight fatty acid derivative, a method for preparing the derivative, and an anticancer composition containing the derivative are provided to improve the anticancer activity remarkably. An unsaturated high molecular weight fatty acid derivative is represented by the formula 1, wherein R is a C18-C22 alkenyl group; n is an integer of 1-400; m is an integer of 0-200; and l is an integer of 0-400. Also the unsaturated high molecular weight fatty acid derivative is represented by the formula 2, wherein R is a C18-C22 alkenyl group; and X, X', X'', X''', Y, Y', Y'' and Y''' are an integer of 1-400.
Abstract translation: 提供不饱和高分子量脂肪酸衍生物，制备该衍生物的方法和含有该衍生物的抗癌组合物，以显着提高抗癌活性。 不饱和高分子量脂肪酸衍生物由式1表示，其中R是C 18 -C 22烯基; n为1-400的整数; m是0-200的整数; l为0-400的整数。 此外，不饱和高分子量脂肪酸衍生物由式2表示，其中R是C 18 -C 22烯基; X，X'，X“，X”'，Y，Y'，Y“和Y”'为1-400的整数。
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公开(公告)号：KR100856938B1
公开(公告)日：2008-09-05
申请号：KR1020060039032
申请日：2006-04-28
Applicant: 재단법인서울대학교산학협력재단
Abstract: 본 발명은 불포화 고급지방산의 페길화 방법에 관한 것으로, 보다 구체적으로는 용매나 촉매를 쓰지 않는 온도 처리의 간단한 방법으로 불포화 고급지방산을 PEGylation 시킬 수 있고, 페길화 고급지방산에 의해 반응 전 불포화 고급지방산이 갖는 고유한 성질은 유지시키면서 세포에 대한 독성을 줄였으며, 제조된 페길화 고급지방산은 core-shell 특성을 가진 나노입자를 형성함으로써 약물의 방출 조절과 안정성을 높일 수 있으므로 페길화에 의해 안정화되고 반추위 미생물들에 의한 이성화 방지가 가능한 신규한 페길화 고급지방산을 제공할 수 있는 매우 뛰어난 효과가 있다.
불포화 고급지방산, CLA, 공액 리놀레산, 페길화, 지방산, 반추위, 폴리에틸렌글리콜-
公开(公告)号：KR1020070106315A
公开(公告)日：2007-11-01
申请号：KR1020060039032
申请日：2006-04-28
Applicant: 재단법인서울대학교산학협력재단
CPC classification number: A61K47/60 , C08G65/329
Abstract: A method for polyethylene glycolylation(PEGylation) of an unsaturated higher fatty acid is provided to avoid the use of a solvent or catalyst while inhibiting undesired isomerization, to obtain a PEGylated higher fatty acid having low cytotoxicity, drug release controllability and stability. A method for PEGylation of an unsaturated higher fatty acid comprises a step of reacting an unsaturated higher fatty acid with polyethylene glycol at 60-200 deg.C for 30 minutes to 10 hours under agitation. The unsaturated higher fatty acid has 16-22 carbon atoms, and examples thereof include alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, conjugated linoleic acid, linoleic acid, gamma-linolenic acid, arachidonic acid, timnodonic acid, cervonic acid, linolenic acid and oleic acid.
Abstract translation: 提供了一种不饱和高级脂肪酸的聚乙二醇糖化（PEG化）方法，以避免使用溶剂或催化剂同时抑制不想要的异构化，获得具有低细胞毒性，药物释放可控性和稳定性的聚乙二醇化高级脂肪酸。 用于不饱和高级脂肪酸聚乙二醇化的方法包括在搅拌下在60-200℃使不饱和高级脂肪酸与聚乙二醇反应30分钟至10小时的步骤。 不饱和高级脂肪酸具有16-22个碳原子，其实例包括α-亚麻酸，二十碳五烯酸，二十二碳六烯酸，共轭亚油酸，亚油酸，γ-亚麻酸，花生四烯酸，timnodonic酸，cervonic acid，亚麻酸 和油酸。
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