Abstract:
A composition for treatment of breast cancer is provided to investigate anti-cancer capability and mechanism in MCF-7 breast cancer cell using alpha-eleostearic acid. A composition for treatment of breast cancer includes alpha-eleostearic acid to active ingredient. A remedial method of disease at cancer cell line includes a step of processing the alpha-eleostearic acid of a therapeutically effective amount to the cancer cell line and prevents, suppresses or improves pathology or symptom of diseases by adjustment of PPAR gamma activity or phosphorylation of ERK1/2.
Abstract:
본 발명은 항암용 불포화 고급지방산 유도체 및 그 제조 방법에 관한 것으로, 용매나 촉매를 쓰지 않는 온도 처리의 간단한 방법으로 불포화 고급지방산에 폴리에틸렌글리콜 또는 폴리에틸렌글리콜과 폴리프로필렌글리콜의 공중합체를 결합시켜 항암활성이 향상된 불포화 고급지방산 유도체를 제조하는 방법 및 이로부터 제조된 항암용 불포화 고급지방산 유도체를 제공할 수 있는 매우 뛰어난 효과가 있다. 불포화 고급지방산, CLA, 공액 리놀레산, 폴리에틸렌글리콜, 폴리프로필렌글리콜, 공중합체, 항암
Abstract:
An unsaturated high molecular weight fatty acid derivative, a method for preparing the derivative, and an anticancer composition containing the derivative are provided to improve the anticancer activity remarkably. An unsaturated high molecular weight fatty acid derivative is represented by the formula 1, wherein R is a C18-C22 alkenyl group; n is an integer of 1-400; m is an integer of 0-200; and l is an integer of 0-400. Also the unsaturated high molecular weight fatty acid derivative is represented by the formula 2, wherein R is a C18-C22 alkenyl group; and X, X', X'', X''', Y, Y', Y'' and Y''' are an integer of 1-400.