公开(公告)号：KR101072504B1

公开(公告)日：2011-10-11

申请号：KR1020097004571

申请日：2007-08-03

Applicant: 포항공과대학교 산학협력단

Inventor： 류성호 ,  서판길 ,  하상훈 ,  이미남 ,  이현주 ,  김일신 ,  김도형 ,  이태훈

IPC: A61K38/43 ,  A61K38/16 ,  A61P35/00 ,  A61P3/04

CPC classification number: C12Q1/485 ,  A61K38/00 ,  C12N9/16 ,  C12Q1/34 ,  G01N2333/9121 ,  G01N2333/916

Abstract: 본발명은포스포리파아제 D (PLD) 및 Rheb (Ras homolog enriched in brain)에의한 mTOR 조절메커니즘의신규한연구결과에기초한포유류라파마이신표적 (mTOR) 조절방법에관한것이다. 또한, 본발명은 mTOR 억제제검출방법, mTOR 억제제에의한 mTOR 관련대사성질환의치료용조성물및 치료방법에관한것이다.

公开(公告)号：KR1020090040364A

公开(公告)日：2009-04-23

申请号：KR1020097004571

申请日：2007-08-03

Applicant: 포항공과대학교 산학협력단

Inventor： 류성호 ,  서판길 ,  하상훈 ,  이미남 ,  이현주 ,  김일신 ,  김도형 ,  이태훈

IPC: A61K38/43 ,  A61K38/16 ,  A61P35/00 ,  A61P3/04

CPC classification number: C12Q1/485 ,  A61K38/00 ,  C12N9/16 ,  C12Q1/34 ,  G01N2333/9121 ,  G01N2333/916

Abstract: A method of regulating mammalian target-of-rapamycin(mTOR) activity based on mTOR control mechanism by phospholipase D(PLD) AND Rheb(Ras homolog enriched in brain) is provided to cure mTOR-related metabolic disease through the mTOR suppression. A method of regulating mammalian target-of-rapamycin(mTOR) activity comprises (i) coupling Rheb and mTOR through PLD2 by interaction between phospholipase D 2(PLD2) and Rheb; (ii) increasing the concentration of PA by moving phosphatidic acid(PA) produced from PLD2 to adjacent mTOR; and (iii) increasing mTOR kinase activity by coupling Rheb with mTOR through the increase of PA density around the adjacent mTOR.

Abstract translation: 提供基于mTOR通过磷脂酶D（PLD）的控制机制调节哺乳动物雷帕霉素（mTOR）活性的方法和Rheb（Ras同源物富含脑），以通过mTOR抑制来治愈mTOR相关代谢疾病。 调节哺乳动物雷帕霉素靶向（mTOR）活性的方法包括：（i）通过磷脂酶D 2（PLD2）和Rheb之间的相互作用使PLD2连接Rheb和mTOR; （ii）通过将由PLD2产生的磷脂酸（PA）移动到相邻的mTOR来增加PA的浓度; 和（iii）通过在相邻mTOR周围增加PA密度增加，通过将Rheb与mTOR偶联来增加mTOR激酶活性。

公开(公告)号：KR1020090037498A

公开(公告)日：2009-04-15

申请号：KR1020097004570

申请日：2007-08-03

Applicant: 포항공과대학교 산학협력단

Inventor： 류성호 ,  서판길 ,  하상훈 ,  김도형 ,  김일신 ,  김정환 ,  이미남 ,  이현주 ,  김종헌 ,  장승기 ,  이태훈

IPC: A61K38/16 ,  A61P35/00 ,  A61P3/04 ,  A61P3/10

CPC classification number: A61K38/1709 ,  C07K14/4702 ,  C12N9/20 ,  C12Y301/04004 ,  G01N33/5011 ,  G01N2333/9121 ,  G01N2333/916

Abstract: A method for controlling the activity of mTOR(mammalian target-of-rapamycin) with the interaction of phospholipase D(PLD) and raptor is provided to cure metabolic diseases related with mTOR by controlling mTOR through the control of the PLD activity. A method for controlling the activity of mTOR(mammalian target-of-rapamycin) is to suppress PLD2 through raptor and mTOR complex(PLD/raptor/mTOR complex) by suppressing the interaction of PLD2 and raptor. Suppressing the formation of the PLD/raptor/mTOR complex is performed by inactivating a raptor binding domain of PLD2 or a PLD2 binding domain of raptor.

Abstract translation: 提供了通过控制mTOR通过控制PLD活性来控制mTOR（哺乳动物雷帕霉素靶）与磷脂酶D（PLD）和猛禽相互作用的活性的方法，以治疗与mTOR相关的代谢疾病。 用于控制mTOR（哺乳动物雷帕霉素靶）活性的方法是通过抑制PLD2和猛禽的相互作用来抑制PLD2通过猛禽和mTOR复合物（PLD / raptor / mTOR复合物）。 抑制PLD / raptor / mTOR复合物的形成是通过灭活猛禽的PLD2或PLD2结合结构域的猛禽结合结构域来实现的。