公开(公告)号：KR1020090037498A

公开(公告)日：2009-04-15

申请号：KR1020097004570

申请日：2007-08-03

Applicant: 포항공과대학교 산학협력단

Inventor： 류성호 ,  서판길 ,  하상훈 ,  김도형 ,  김일신 ,  김정환 ,  이미남 ,  이현주 ,  김종헌 ,  장승기 ,  이태훈

IPC: A61K38/16 ,  A61P35/00 ,  A61P3/04 ,  A61P3/10

CPC classification number: A61K38/1709 ,  C07K14/4702 ,  C12N9/20 ,  C12Y301/04004 ,  G01N33/5011 ,  G01N2333/9121 ,  G01N2333/916

Abstract: A method for controlling the activity of mTOR(mammalian target-of-rapamycin) with the interaction of phospholipase D(PLD) and raptor is provided to cure metabolic diseases related with mTOR by controlling mTOR through the control of the PLD activity. A method for controlling the activity of mTOR(mammalian target-of-rapamycin) is to suppress PLD2 through raptor and mTOR complex(PLD/raptor/mTOR complex) by suppressing the interaction of PLD2 and raptor. Suppressing the formation of the PLD/raptor/mTOR complex is performed by inactivating a raptor binding domain of PLD2 or a PLD2 binding domain of raptor.

Abstract translation: 提供了通过控制mTOR通过控制PLD活性来控制mTOR（哺乳动物雷帕霉素靶）与磷脂酶D（PLD）和猛禽相互作用的活性的方法，以治疗与mTOR相关的代谢疾病。 用于控制mTOR（哺乳动物雷帕霉素靶）活性的方法是通过抑制PLD2和猛禽的相互作用来抑制PLD2通过猛禽和mTOR复合物（PLD / raptor / mTOR复合物）。 抑制PLD / raptor / mTOR复合物的形成是通过灭活猛禽的PLD2或PLD2结合结构域的猛禽结合结构域来实现的。