公开(公告)号：DE69617701D1

公开(公告)日：2002-01-17

申请号：DE69617701

申请日：1996-05-28

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  LIN NAN-HORNG ,  RYTHER B ,  HE YUN

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R , R , A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：DE60006213T2

公开(公告)日：2004-07-29

申请号：DE60006213

申请日：2000-01-25

Applicant: ABBOTT LAB

Inventor： BUNNELLE H ,  CRISTINA BARLOCCO ,  DAANEN F ,  DART J ,  MEYER D ,  RYTHER B ,  SCHRIMPF R ,  SIPPY B ,  TOUPENCE B

IPC: A61K31/00 ,  A61K31/407 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  C07D401/08 ,  C07D471/08 ,  C07D487/08 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61K31/395

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：DE60006213D1

公开(公告)日：2003-12-04

申请号：DE60006213

申请日：2000-01-25

Applicant: ABBOTT LAB

Inventor： BUNNELLE H ,  CRISTINA BARLOCCO ,  DAANEN F ,  DART J ,  MEYER D ,  RYTHER B ,  SCHRIMPF R ,  SIPPY B ,  TOUPENCE B

IPC: A61K31/00 ,  A61K31/407 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  C07D401/08 ,  C07D471/08 ,  C07D487/08 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61K31/395

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：DE69617701T2

公开(公告)日：2002-10-17

申请号：DE69617701

申请日：1996-05-28

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  LIN NAN-HORNG ,  RYTHER B ,  HE YUN

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61P25/00 ,  A61P25/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel 3-pyridyloxymethyl heterocyclic ether compounds having formula (I), wherein * is a chiral center and n, X, R , R , A andB are specifically defined, which are useful in controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions therof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：DE69612292T2

公开(公告)日：2001-11-22

申请号：DE69612292

申请日：1996-07-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT L ,  RYTHER B ,  HOLLADAY W ,  WASICAK T ,  DAANEN F

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/4355 ,  A61P9/00 ,  A61P25/00 ,  A61P25/30 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00

Abstract: Novel heterocyclic ether compounds having the formula: wherein A, m, R, X, Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：DE69813536T2

公开(公告)日：2004-02-19

申请号：DE69813536

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK T ,  GARVEY S ,  HOLLADAY W ,  LIN NAN-HORNG ,  RYTHER B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：DE69717148T2

公开(公告)日：2003-10-02

申请号：DE69717148

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  ARNERIC P ,  BAI HAO ,  DART J ,  LIN NAN-HORNG ,  LYNCH K ,  OR SUN ,  RYTHER B ,  SULLIVAN P ,  WASICAK T ,  EHRLICH P

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：DE69813536D1

公开(公告)日：2003-05-22

申请号：DE69813536

申请日：1998-02-05

Applicant: ABBOTT LAB

Inventor： WASICAK T ,  GARVEY S ,  HOLLADAY W ,  LIN NAN-HORNG ,  RYTHER B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/44

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：DE69717148D1

公开(公告)日：2002-12-19

申请号：DE69717148

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY W ,  ARNERIC P ,  BAI HAO ,  DART J ,  LIN NAN-HORNG ,  LYNCH K ,  OR SUN ,  RYTHER B ,  SULLIVAN P ,  WASICAK T ,  EHRLICH P

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：DE69612292D1

公开(公告)日：2001-05-03

申请号：DE69612292

申请日：1996-07-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT L ,  RYTHER B ,  HOLLADAY W ,  WASICAK T ,  DAANEN F

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/4355 ,  A61P9/00 ,  A61P25/00 ,  A61P25/30 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00

Abstract: Novel heterocyclic ether compounds having the formula: wherein A, m, R, X, Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.