公开(公告)号：DE69613347T2

公开(公告)日：2002-04-18

申请号：DE69613347

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA Z ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  LEBOLD A ,  LEE L ,  PRATT K ,  SIPPY B ,  TIETJE R ,  YAMAMOTO M

IPC: A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  C07D487/02 ,  C07D495/02 ,  C07D487/00

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：DE69613347D1

公开(公告)日：2001-07-19

申请号：DE69613347

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA Z ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  LEBOLD A ,  LEE L ,  PRATT K ,  SIPPY B ,  TIETJE R ,  YAMAMOTO M

IPC: A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  C07D487/02 ,  C07D495/02 ,  C07D487/00

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：DE69609051T2

公开(公告)日：2001-03-22

申请号：DE69609051

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA Z ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  LEBOLD A ,  LEE L ,  ELMORE W ,  SIPPY B ,  TIETJE R ,  WENDT D ,  YAMAMOTO M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：DE60006213D1

公开(公告)日：2003-12-04

申请号：DE60006213

申请日：2000-01-25

Applicant: ABBOTT LAB

Inventor： BUNNELLE H ,  CRISTINA BARLOCCO ,  DAANEN F ,  DART J ,  MEYER D ,  RYTHER B ,  SCHRIMPF R ,  SIPPY B ,  TOUPENCE B

IPC: A61K31/00 ,  A61K31/407 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  C07D401/08 ,  C07D471/08 ,  C07D487/08 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61K31/395

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：DE60006213T2

公开(公告)日：2004-07-29

申请号：DE60006213

申请日：2000-01-25

Applicant: ABBOTT LAB

Inventor： BUNNELLE H ,  CRISTINA BARLOCCO ,  DAANEN F ,  DART J ,  MEYER D ,  RYTHER B ,  SCHRIMPF R ,  SIPPY B ,  TOUPENCE B

IPC: A61K31/00 ,  A61K31/407 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61P9/10 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  C07D401/08 ,  C07D471/08 ,  C07D487/08 ,  C07D491/048 ,  C07D495/04 ,  C07D519/00 ,  A61K31/395

Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein: V is selected from the group consisting of a covalent bond and CH2; W is selected from the group consisting of a covalent bond, CH2 and CH2CH2; X is selected from the group consisting of a covalent bond and CH2; Y is selected from the group consisting of a covalent bond, CH2 and CH2CH2; Z is selected from the group consisting of CH2 and CH2CH2, and CH2CH2CH2; L1 is selected from the group consisting of a covalent bond and (CH2)n; n is 1-5; R1 is selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), and (l); R2 is selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxy, hydroxyalkyl, phenoxycarbonyl, and -NH2; are useful for controlling synaptic transmission in mammal.

公开(公告)号：DE69609051D1

公开(公告)日：2000-08-03

申请号：DE69609051

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA Z ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  LEBOLD A ,  LEE L ,  ELMORE W ,  SIPPY B ,  TIETJE R ,  WENDT D ,  YAMAMOTO M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.