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公开(公告)号：DE69631609D1
公开(公告)日：2004-03-25
申请号：DE69631609
申请日：1996-10-17
Applicant: ABBOTT LAB
Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R , R and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.
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公开(公告)号：DE69612292D1
公开(公告)日：2001-05-03
申请号：DE69612292
申请日：1996-07-25
Applicant: ABBOTT LAB
Inventor： ELLIOTT L , RYTHER B , HOLLADAY W , WASICAK T , DAANEN F
IPC: A61K31/00 , A61K31/435 , A61K31/4353 , A61K31/4355 , A61P9/00 , A61P25/00 , A61P25/30 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Novel heterocyclic ether compounds having the formula: wherein A, m, R, X, Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.
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公开(公告)号：DE69626040T2
公开(公告)日：2004-01-22
申请号：DE69626040
申请日：1996-11-06
Applicant: ABBOTT LAB
Inventor： OR SUN , CHU T , ELLIOTT L , PIREH DAISY
IPC: A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P31/04 , C07H17/08
Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.
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公开(公告)号：DE69612292T2
公开(公告)日：2001-11-22
申请号：DE69612292
申请日：1996-07-25
Applicant: ABBOTT LAB
Inventor： ELLIOTT L , RYTHER B , HOLLADAY W , WASICAK T , DAANEN F
IPC: A61K31/00 , A61K31/435 , A61K31/4353 , A61K31/4355 , A61P9/00 , A61P25/00 , A61P25/30 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Novel heterocyclic ether compounds having the formula: wherein A, m, R, X, Y1, Y2 and Y3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.
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公开(公告)号：DE69427361D1
公开(公告)日：2001-07-05
申请号：DE69427361
申请日：1994-08-30
Applicant: ABBOTT LAB
Inventor： LIN NAN-HORNG , HE YUN , ELLIOTT L , CHORGHADE S , WITTENBERGER J , BUNNELLE H , NARAYANAN A , SINGAM PULLA R , ESCH K , BEER O , WITZIG C , HERZIG C , RAO V RAMA
IPC: C07D413/04 , C07D207/09
Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
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Patent Agency Ranking
公开(公告)号：DE69626040D1
公开(公告)日：2003-03-06
申请号：DE69626040
申请日：1996-11-06
Applicant: ABBOTT LAB
Inventor： OR SUN , CHU T , ELLIOTT L , PIREH DAISY
IPC: A61K31/00 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P31/04 , C07H17/08
Abstract: A compound selected from groups (I), (II), and (III), wherein A, B, V, W, X and R are specifically defined; pharmaceutical compositions thereof; a method of treating or preventing bacterial infections by administering therapeutically effective pharmaceutical compositions thereof; and a process for the preparation thereof.
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公开(公告)号：DE69822668T2
公开(公告)日：2005-03-10
申请号：DE69822668
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HOLLADAY W , ABREO A , GUNN E , LIN NAN-HORNG , GARVEY S , RYTHER KEITH , LEBOLD A , ELLIOTT L , HE YUN , WASIAK T , BAI HAO , DART J , EHRLICH P , LI YIHONG , KINCAID F , SCHKERYANTZ M , LYNCH K
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/50 , A61K31/505
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公开(公告)号：DE69631609T2
公开(公告)日：2005-01-05
申请号：DE69631609
申请日：1996-10-17
Applicant: ABBOTT LAB
Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R , R and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.
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公开(公告)号：DE69723848T2
公开(公告)日：2004-07-01
申请号：DE69723848
申请日：1997-04-25
Applicant: ABBOTT LAB
Inventor： ELLIOTT L , OR SUN , CHU T , GRIESGRABER W , PLATTNER J , PIREH DAISY
IPC: A61K31/04 , A61K31/70 , A61K31/7048 , A61K31/7052 , C07H17/08
Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.
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公开(公告)号：DE69822668D1
公开(公告)日：2004-04-29
申请号：DE69822668
申请日：1998-12-18
Applicant: ABBOTT LAB
Inventor： HOLLADAY W , ABREO A , GUNN E , LIN NAN-HORNG , GARVEY S , RYTHER KEITH , LEBOLD A , ELLIOTT L , HE YUN , WASIAK T , BAI HAO , DART J , EHRLICH P , LI YIHONG , KINCAID F , SCHKERYANTZ M , LYNCH K
IPC: A61K31/427 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61P25/00 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/12 , C07D403/12 , C07D417/12 , C07D455/02 , C07D487/04 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/50 , A61K31/505
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