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    METHOD FOR PRODUCING (1-10C)ALKYL 2-KETO-L-GULONATE
    1.
    发明专利
    METHOD FOR PRODUCING (1-10C)ALKYL 2-KETO-L-GULONATE 失效

    公开(公告)号：JP2001106695A

    公开(公告)日：2001-04-17

    申请号：JP2000247011

    申请日：2000-08-16

    Applicant: BASF AG

    Inventor： BOETTCHER ANDREAS ,  BURST WOLFRAM

    IPC: C07B61/00 ,  C07H1/00 ,  C07H7/027

    Abstract: PROBLEM TO BE SOLVED: To obtain a (1-10C)alkyl 2-keto-L-gulonate as an intermediate for synthesizing L-ascorbic acid (vitamin C) in a sufficiently low residual water content rate and a short esterification reaction residence time. SOLUTION: In the method for producing the (1-10C)alkyl 2-keto-L-gulonate by esterifying 2-keto-L-gulonic acid or diacetone-2-keto-L-gulonic acid with a 1-10C alcohol in the presence of an acidic catalyst, esterification is carried out in the hot surface of a liquid film while removing water at the same time. Solid is not formed in a reactor though keto-L-gulonic acid is difficultly soluble in an lower alcohol such as methanol, ethanol, propanol, butanol or pentanol and a produced ester is present in a state not containing a solvent after removing water.

    PRODUCTION OF L-ASCORBIC ACID
    2.
    发明专利
    PRODUCTION OF L-ASCORBIC ACID 失效

    公开(公告)号：JP2000319271A

    公开(公告)日：2000-11-21

    申请号：JP2000124500

    申请日：2000-04-25

    Applicant: BASF AG

    Inventor： BOETTCHER ANDREAS ,  GURSKI HANS ,  KUNTZE THOMAS ,  KJAERGAARD KARSTEN

    IPC: C07B61/00 ,  C07D307/62

    Abstract: PROBLEM TO BE SOLVED: To provide a method for producing L-ascorbic acid representing no drawbacks involved in the corresponding conventional technology. SOLUTION: This method for producing L-ascorbic acid comprises lactonization of a solution containing a 2-keto-L-gulonic acid-3-10C alkyl ester under an acidic condition; wherein the lactonization is preferably carried out in an inert solvent immiscible with water in the presence of a mineral acid; alternatively, it is preferable that, the lactonization is carried out in a halocarbon in the presence of aqueous hydrochloric acid; in this case, the halocarbon as inert solvent to be used is selected from the group consisting of dichloromethane, chloroform and perchloroethylene.

    METHOD FOR PRODUCING ALKALI METAL SALT OF L-ASCORBIC ACID
    3.
    发明专利
    METHOD FOR PRODUCING ALKALI METAL SALT OF L-ASCORBIC ACID 失效

    公开(公告)号：JP2001151765A

    公开(公告)日：2001-06-05

    申请号：JP2000342489

    申请日：2000-11-09

    Applicant: BASF AG

    Inventor： BURST WOLFRAM ,  KAIBEL GERD DR ,  BOETTCHER ANDREAS ,  KESSLER VERONIQUE ,  KUNTZE THOMAS

    IPC: B01D3/32 ,  C07B61/00 ,  C07D307/62

    Abstract: PROBLEM TO BE SOLVED: To provide a method for continuously producing an alkali metal salt of L-ascorbic acid at an inexpensive cost of apparatus without causing reduction in yield. SOLUTION: In the case of producing the alkali metal salt of L-ascorbic acid by a method including a process (a) for esterifying 2-keto-L-gluconic acid or diacetone-2-keto-L-gluconic acid with a 1-10C alcohol in the presence of an acid catalyst and a process (b) for rearranging a formed 2-keto-L-gluconic acid 1-10C alkyl ester in the presence of a 1-10C alkali metal alcoholate, the treatment process (a) and the treatment process (b) are continuously carried out.

    PRODUCTION OF SALT OF ASCORBYL-2-PHOSPHATE
    5.
    发明专利
    PRODUCTION OF SALT OF ASCORBYL-2-PHOSPHATE 失效

    公开(公告)号：JP2000034296A

    公开(公告)日：2000-02-02

    申请号：JP19898699

    申请日：1999-07-13

    Applicant: BASF AG

    Inventor： BOETTCHER ANDREAS ,  GURSKI HANS

    IPC: C07F9/655

    Abstract: PROBLEM TO BE SOLVED: To produce a salt of ascorbyl-2-phosphate useful for a cosmetic or the like in a good efficiency, high purity and high yield by dissolving calcium ascorbate phosphate in an aqueous solution of ascorbyl phosphate within a prescribed acidic pH region, and treating the obtained solution under a specific condition. SOLUTION: Calcium ascorbate-2-phosphate of formula I (P is a group of formula II or the like) is dissolved in an aqueous solution of ascorbyl-2- phosphate of formula II (P1 is H2PO3, H3P2O6 or H4P3O9) at a pH value of 0.5-4, and calcium ion is removed from the obtained solution. The remaining solution is regulated so as to have 7-11 pH value by a sodium salt, a potassium salt, a magnesium salt or an aluminum salt, and the formula salt of ascorbyl-2- phosphate of formula IV [M is sodium, potassium, magnesium or aluminum; the product of (k).(m) is 3-5] is isolated to provide the objective salt of ascorbyl-2-phosphate of formula IV. The Ca++ is preferably removed by using an ion exchange resin of a strong acid.

    7.
    发明专利
    未知

    公开(公告)号：AT277030T

    公开(公告)日：2004-10-15

    申请号：AT01931684

    申请日：2001-05-03

    Applicant: BASF AG

    Inventor： BOETTCHER ANDREAS ,  BURST WOLFRAM

    IPC: A61K31/375 ,  A61P3/02 ,  C07B61/00 ,  C07D307/62

    Abstract: The invention relates to a process for the preparation of L-ascorbic acid, in which free 2-keto-L-gulonic acid or C3-C10-alkyl 2-keto-L-gulonate is lactonized under acidic conditions in the presence of a water-miscible solvent and where this solvent in situ forms a solvent in which the ascorbic acid formed is poorly soluble.

    8.
    发明专利
    未知

    公开(公告)号：BR0110657A

    公开(公告)日：2003-03-18

    申请号：BR0110657

    申请日：2001-05-03

    Applicant: BASF AG

    Inventor： BOETTCHER ANDREAS ,  BURST WOLFRAM

    IPC: A61K31/375 ,  A61P3/02 ,  C07B61/00 ,  C07D307/62

    Abstract: The invention relates to a process for the preparation of L-ascorbic acid, in which free 2-keto-L-gulonic acid or C3-C10-alkyl 2-keto-L-gulonate is lactonized under acidic conditions in the presence of a water-miscible solvent and where this solvent in situ forms a solvent in which the ascorbic acid formed is poorly soluble.

    10.
    发明专利
    未知

    公开(公告)号：DE58904500D1

    公开(公告)日：1993-07-01

    申请号：DE58904500

    申请日：1989-12-27

    Applicant: BASF AG

    Inventor： REHMER GERD ,  BOETTCHER ANDREAS ,  AUCHTER GERHARD

    IPC: C08F212/08 ,  C08F2/46 ,  C08F20/10 ,  C08F20/26 ,  C08F20/52 ,  C08F212/00 ,  C08F220/18 ,  C08F220/30 ,  C08F220/58 ,  C08F290/00 ,  C08F290/06 ,  C08F299/00 ,  C09D4/00 ,  C09D133/04 ,  C09J4/00 ,  C09J133/04

    Abstract: UV-crosslinkable materials based on (meth)acrylate copolymers contain copolymerized monomers of the general formula I (I) where R is a certain alkyl radical, an aryl radical or a radical R1 and R1 is a radical where R2 to R6 are each H, alkyl, a non-ortho OH group, OCH3, OC2H3, SH, SCH3, Cl, F, CN, COOH, COO(C1-C3-alkyl), CF3, N(CH3)2, N(C2H5)2, N(CH3)C6H5, +N(CH3)3X- or +N(CH3)XX-, where X- is an acid anion, and one or more of the radicals R2 to R6 are each a radical or or where Sp is one of the spacer groups of the following type and R', R'' and R''' are each H or a certain hydrocarbon, and where the radicals X may be identical or different and are each a divalent, alkylene radical, a cycloalkylene radical or phenylene radical, which are bonded directly to one another and/or are bonded to one another by identical or different groups Y, and Y is a divalent radical from the group consisting of and k and m are each from 1 to 10 and 1 and n are each from 0 to 25.

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