公开(公告)号：JP2004043502A

公开(公告)日：2004-02-12

申请号：JP2003358317

申请日：2003-10-17

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/715 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K38/00 ,  C07K14/7151

Abstract: PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα (tumor necrusis factor α).
SOLUTION: This protein has molecular weight of about 42,000 daltons measured by SDS gel electrophoresis and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and a mutein is obtained by subjecting the protein having the TNFα suppressing action to a proper substitution, deletion or addition of an amino acid or peptide or the change of a glycoside group without strongly lowering the TNFα suppressing action.
COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2002302500A

公开(公告)日：2002-10-18

申请号：JP2002013319

申请日：2002-01-22

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα. SOLUTION: The protein has a molecular weight of about 42,000 daltons in the first glycosylated form and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and the protein and a mutein obtained by the proper substitution, deletion or addition of an amino acid or peptide for/ from/or to/the protein or the change of a glycoside group without strongly lowering the action of the protein are used for suppressing the abnormal increase in the TNF-α.

公开(公告)号：WO9010006A3

公开(公告)日：1990-11-01

申请号：PCT/EP9000280

申请日：1990-02-20

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  KEILHAUER GERHARD ,  SAUTER HUBERT ,  BERTRAM GUNDA ,  ANKE TIMM ,  WEBER WOLFGANG ,  STEGLICH WOLFGANG

IPC: C07D319/14 ,  A61K31/335 ,  A61K31/357 ,  A61P31/04 ,  C07D407/12 ,  C07D493/10

CPC classification number: C07D407/12 ,  C07D493/10

Abstract: β-methoxyacrylates of formula (I), in which R?1, R2 and R3¿ have the meanings given in the description, are useful for treating diseases. Their production is also described.

公开(公告)号：WO9006943A3

公开(公告)日：1990-08-09

申请号：PCT/EP8901470

申请日：1989-12-02

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  DAUM LOTHAR ,  HAUPT ANDREAS ,  SCHMIED BERNHARD ,  WALKER NIGEL ,  ZECHEL JOHANN-CHRISTIAN

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/52 ,  C07K14/525 ,  A61K37/02 ,  C07K7/56

CPC classification number: C07K14/525 ,  A61K38/00

Abstract: Peptides derived from TNF, of formula (I): X-A-Gly-Asp-Y, in which A X and Y have the meanings given in the description. Process for producing them. The novel peptides are useful therapeutic agents.

公开(公告)号：AU615541B2

公开(公告)日：1991-10-03

申请号：AU3406089

申请日：1989-05-05

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  KEILHAUER GERHARD ,  LORENZ GISELA ,  AMMERMANN EBERHARD ,  ANKE TIMM ,  WEBER WOLFGANG ,  STEGLICH WOLFGANG ,  STEFFAN BERT ,  SCHERER ANGELA

IPC: C12P17/18 ,  A01N43/90 ,  A61K31/335 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07D493/10 ,  C12R1/645 ,  C12P17/06

Abstract: Novel strobilurine derivatives which are suitable for the treatment of disorders and as fungicides are described.

公开(公告)号：AU608677B2

公开(公告)日：1991-04-11

申请号：AU2749288

申请日：1988-12-23

Applicant: BASF AG

Inventor： HERR DIETER ,  DOERPER THOMAS ,  DAUM LOTHAR ,  GEISS KARL-HEINZ ,  MOELLER ACHIM

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12 ,  A61K31/725

公开(公告)号：AU607941B2

公开(公告)日：1991-03-21

申请号：AU7999687

申请日：1987-10-21

Applicant: BASF AG

Inventor： SEITZ WERNER ,  DAUM LOTHAR ,  EMLING FRANZ ,  KEILHAUER GERHARD

IPC: A61K31/275 ,  A61K31/277 ,  A61P35/00

公开(公告)号：CA2425101A1

公开(公告)日：1990-11-15

申请号：CA2425101

申请日：1990-05-04

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  SUBKOWSKI THOMAS ,  DOERPER THOMAS ,  DAUM LOTHAR ,  MOELLER ACHIM

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.

公开(公告)号：CA2005056A1

公开(公告)日：1990-06-12

申请号：CA2005056

申请日：1989-12-11

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  DAUM LOTHAR ,  HAUPT ANDREAS ,  SCHMIED BERNHARD ,  WALKER NIGEL ,  ZECHEL JOHANN-CHRISTIAN

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/19 ,  C07K7/50 ,  C07K7/64

Abstract: Peptides of the formula X-Ala-His-A-Y, where A, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.

公开(公告)号：CA2005050A1

公开(公告)日：1990-06-12

申请号：CA2005050

申请日：1989-12-11

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  DAUM LOTHAR ,  HAUPT ANDREAS ,  SCHMIED BERNHARD ,  WALKER NIGEL ,  ZECHEL JOHANN-CHRISTIAN

IPC: A61K38/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K1/04 ,  C07K7/06 ,  C07K7/08 ,  C07K7/64 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/19 ,  C07K7/02 ,  C07K7/50

Abstract: Peptides of the formula X-Pro-A-B-Y where A, B, X and Y are defined in the description, and the preparation thereof are described. The novel peptides are suitable for controlling diseases.