公开(公告)号：JP2004043502A

公开(公告)日：2004-02-12

申请号：JP2003358317

申请日：2003-10-17

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフト

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/715 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K38/00 ,  C07K14/7151

Abstract: PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα (tumor necrusis factor α).
SOLUTION: This protein has molecular weight of about 42,000 daltons measured by SDS gel electrophoresis and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and a mutein is obtained by subjecting the protein having the TNFα suppressing action to a proper substitution, deletion or addition of an amino acid or peptide or the change of a glycoside group without strongly lowering the TNFα suppressing action.
COPYRIGHT: (C)2004,JPO

公开(公告)号：JP2002302500A

公开(公告)日：2002-10-18

申请号：JP2002013319

申请日：2002-01-22

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  MOELLER ACHIM ,  DAUM LOTHAR ,  DOERPER THOMAS ,  SUBKOWSKI THOMAS

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα. SOLUTION: The protein has a molecular weight of about 42,000 daltons in the first glycosylated form and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and the protein and a mutein obtained by the proper substitution, deletion or addition of an amino acid or peptide for/ from/or to/the protein or the change of a glycoside group without strongly lowering the action of the protein are used for suppressing the abnormal increase in the TNF-α.

公开(公告)号：AU608677B2

公开(公告)日：1991-04-11

申请号：AU2749288

申请日：1988-12-23

Applicant: BASF AG

Inventor： HERR DIETER ,  DOERPER THOMAS ,  DAUM LOTHAR ,  GEISS KARL-HEINZ ,  MOELLER ACHIM

IPC: C08B37/10 ,  A61K20060101 ,  A61K31/715 ,  A61P31/12 ,  A61K31/725

公开(公告)号：CA2425101A1

公开(公告)日：1990-11-15

申请号：CA2425101

申请日：1990-05-04

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HILLEN HEINZ ,  SUBKOWSKI THOMAS ,  DOERPER THOMAS ,  DAUM LOTHAR ,  MOELLER ACHIM

IPC: A61K35/22 ,  A61K38/00 ,  A61K38/17 ,  A61K38/19 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P11/00 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K1/18 ,  C07K1/22 ,  C07K7/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/525 ,  C07K14/715 ,  C07K16/18

Abstract: Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.

公开(公告)号：ZA8803428B

公开(公告)日：1990-01-31

申请号：ZA8803428

申请日：1988-05-16

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  THOMAS DOERPER ,  MOELLER ACHIM ,  ACHIM MOELLER ,  HILLEN HEINZ ,  HEINZ HILLEN ,  KEILHAUER GERHARD ,  GERHARD KEILHAUER ,  EMLING FRANZ ,  FRANZ EMLING ,  DAUM LOTHAR ,  LOTHAR DAUM

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C07K ,  C07H ,  C12P

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/525 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/75 ,  Y10S930/144

公开(公告)号：FI882283A

公开(公告)日：1988-11-17

申请号：FI882283

申请日：1988-05-16

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  MOELLER ACHIM ,  HILLEN HEINZ ,  KEILHAUER GERHARD ,  EMLING FRANZ ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C12N

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：DK263588D0

公开(公告)日：1988-05-13

申请号：DK263588

申请日：1988-05-13

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  MOELLER ACHIM ,  HILLEN HEINZ ,  KEILHAUER GERHARD ,  EMLING FRANZ ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  C12N15/00

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：AU7452187A

公开(公告)日：1988-01-07

申请号：AU7452187

申请日：1987-06-19

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS ,  MOELLER ACHIM ,  KOERWER WOLFGANG ,  DOERPER THOMAS ,  HILLEN HEINZ ,  DAUM LOTHAR ,  EMLING FRANZ ,  KEILHAUER GERHARD

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  A61K37/02 ,  A61K37/42 ,  C07G17/00 ,  C07H21/04 ,  C12N1/20 ,  C12P19/34

公开(公告)号：DK312787A

公开(公告)日：1987-12-21

申请号：DK312787

申请日：1987-06-19

Applicant: BASF AG

Inventor： SCHOLLMEIER KLAUS ,  MOELLER ACHIM ,  KOERWER WOLFGANG ,  DOERPER THOMAS

IPC: C07K14/52 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/525 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  C07K13/00 ,  A61K37/02 ,  C07H21/04

公开(公告)号：ZA903475B

公开(公告)日：1992-01-29

申请号：ZA903475

申请日：1990-05-08

Applicant: BASF AG

Inventor： LEMAIRE HANS-GEORG ,  HANS-GEORG LEMAIRE ,  HILLEN HEINZ ,  HEINZ HILLEN ,  MOELLER ACHIM ,  ACHIM MOELLER ,  DAUM LOTHAR ,  LOTHAR DAUM ,  DOERPER THOMAS ,  THOMAS DOERPER ,  SUBKOWSKI THOMAS ,  THOMAS SUBKOWSKI

IPC: C07K20060101 ,  C07K