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    New 3-aryl-methyl-uracil derivatives
    1.
    发明专利
    New 3-aryl-methyl-uracil derivatives 未知

    公开(公告)号：DE19738084A1

    公开(公告)日：1999-03-04

    申请号：DE19738084

    申请日：1997-09-01

    Applicant: BASF AG

    Inventor： MENKE OLAF DR ,  GOETZ ROLAND DR ,  RACK MICHAEL DR ,  HAMPRECHT GERHARD DR ,  MENGES MARKUS DR ,  REINHARD ROBERT DR ,  SCHAEFER PETER DR ,  ZAGAR CYRILL DR ,  WESTPHALEN KARL-OTTO DR ,  WALTER HELMUT DR ,  MISLITZ ULF DR

    IPC: A01N43/80 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07F9/6584 ,  C07D239/54 ,  A01N43/54 ,  A01N43/84 ,  A01N57/02 ,  C07D403/06 ,  C07F9/6564 ,  C07F9/6571

    Abstract: 3-Arylmethyluracil derivatives (I.1)-(I.4) are new, where A = H, 1-4C alkyl, NH2, 1-4C alkylamino or di-(1-4C alkyl)amino; X = O or S; n = not defined; R1 = 1-4C haloalkyl; R2 = H, halo or 1-3C alkyl; R3-R5 = H, CN, thiocyanato, halo, 1-4C haloalkyl, 1-4C haloalkoxy, 1-4C haloalkylthio, 1-4C alkyl or 1-4C alkoxy; R6, R7 = 1-4C alkyl, NH2, 1-4C alkylamino or di(1-4C alkyl)amino, or R6 and R7 together form =O; R8 may be in position alpha or beta and R3 is in the other position; R8 = (1) H, halo, amino, 1-4C alkylsulphonylamino or di(1-4C alkyl)amino; (2) 1-6C alkoxy, 1-6C alkylthio, 3-6C cycloalkoxy, 3-6C cycloalkylthio, 2-6C alkenyloxy, 5-7C cycloalkenyloxy, 2-6C alkenylthio, 2-6C alkynyloxy, 2-6C alkynylthio, (1-6C alkyl)carbonyloxy, (1-6C alkyl)carbonylthio, (1-6C alkoxy)carbonyloxy, (2-6C alkenyl)carbonyloxy, (2-6C alkenyl)carbonylthio, (2-6C alkynyl)carbonyloxy, (2-6C alkynyl)carbonylthio, 1-6C alkylsulphonyloxy or 1-6C alkylsulphonyl, where the last 18 groups may contain 1-4 substituents; (3) CT-R11, C(R11)(Y1R12)(Y2R13), C(R11)=C(R14)CN, C(R11)=C(R14)CO-R15, CH(R11)-CH(R14)CO-R15, C(R11)=C(R14)-CH2-CO-R15, C(R11)=C(R14)-C(R16)=C(R17)-CO-R15, C(R11)=C(R14)-CH2-CH(R18)CO-R15, CO-OR19, CO-SR19, CO-N(R19)-OR20, C?=C-CO-NH-OR20, C?=C-CO-N(R19)-OR20, , C?=C-CS-NH-OR20, C?=C-CS-N(R19)-OR20, C(R11)=C(R14)-CO-NH-OR20, C(R11)=C(R14)-CO-N(R19)-OR20, C(R11)=C(R14)-CS-NH-OR20, C(R11)=C(R14)-CS-N(R19)-OR20, C(R11)=C(R14)-C(R21)=N-OR20, C(R21)=N-OR20, C?=C-C(R21)=N-OR20, C(Y1R12)(Y2R13)-OR19, C(Y1R12)(Y2R13)-SR19, C(Y1R12)(Y2R13)-N(R23)(R24), N(R23)(R24), CO-N(R23)(R24), or groups of formula (i), (ii), -C?=C-(i), -C?=C-(ii), -C(R11)=C(R14)-(i) or -C(R11)=C(R14 )-(ii); Y1, Y2 = S or O; theta = 1-3C alkylene optionally substituted by 1-6C alkyl; R11 = H, CN, 1-6C alkyl, 1-6C haloalkyl, 2-6C alkenyl, 2-6C alkynyl, 3-6C cycloalkyl, 1-6C alkoxy-(1-6C alkyl) or (1-6C alkoxy)carbonyl; R12, R13 = 1-6C alkyl, 1-6C haloalkyl, 3-6C alkenyl, 3-6C alkynyl or 1-6C alkoxy-(1-6C alkyl) or R12 and R13 together form a 2-4 membered carbon chain which is optionally substituted and can contain non-adjacent O, S or N atoms instead of C atoms or be condensed or form a spiro attachment with a 3-7 membered ring; R14 = H, CN, halo, 1-6C alkyl, 1-6C haloalkyl, 1-6C alkoxy, (1-6C alkyl)carbonyl or (1-6C alkoxy)carbonyl; R15 = H, OR22, SR22, 1-6C alkyl (optionally substituted by one or two 1-6C alkoxy groups), 2-6C alkenyl, 2-6C alkynyl, 1-6C haloalkyl, 3-6C cycloalkyl, 1-6C alkylthio-(1-6C alkyl), 1-6C alkyliminooxy, N(R23)(R24) or optionally substituted phenyl; R22 has the same meanings as R19; R16 = H, CN, halo, 1-6C alkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkoxy-(1-6C alkyl), (1-6C alkyl)carbonyl, (1-6C alkoxy)carbonyl, N(R25)(R26) or optionally substituted phenyl; R25, R26 have the same meanings as R23 and R24; R17 = H, halo, CN, 1-6C alkyl, 1-6C alkoxy, 1-6C haloalkyl, (1-6C alkyl)carbonyl or (1-6C alkoxy)carbonyl; R18 = H, CN, 1-6C alkyl or (1-6C alkoxy)carbonyl; R19 = H, 1-6C alkyl, 1-6C haloalkyl, 2-6C alkenyl or 2-6C alkynyl (where the latter four groups are optionally substituted), (1-6C alkyl)carbonyl, (1-6C haloalkyl)carbonyl, (1-6C alkoxy)carbonyl, 1-6C alkylaminocarbonyl, di-(1-6C alkyl)aminocarbonyl, 1-6C alkoxyimino-(1-6C alkyl), 3-6C cycloalkyl, phenyl or phenyl-(1-6C alkyl), where the phenyl ring is optionally substituted; R20 = H, 1-6C alkyl, 1-6C haloalkyl, 3-6C cycloalkyl, 3-6C alkenyl, 3-6C alkynyl, hydroxy-(1-6C alkyl), 1-6C alkoxy-(1-6C alkyl), 1-6C alkylthio-(1-6C alkyl), cyano-(1-6C alkyl), (1-6C alkyl)carbonyl-(1-6C alkyl), (1-6C alkoxy)carbonyl-(1-6C alkyl), (1-6C alkoxy)carbonyl-(2-6C alkenyl), (1-6C alkyl)carbonyloxy-(1-6C alkyl) or phenyl-(1-6C alkyl), where the phenyl ring may contain 1-3 substituents; R

    6.
    发明专利
    未知

    公开(公告)号：DE19755926A1

    公开(公告)日：1999-06-24

    申请号：DE19755926

    申请日：1997-12-17

    Applicant: BASF AG

    Inventor： REINHARD ROBERT DR ,  HAMPRECHT GERHARD DR ,  MENGES MARKUS DR ,  MENKE OLAF DR ,  SCHAEFER PETER DR ,  ZAGAR CYRILL DR ,  HEISTRACHER ELISABETH DR ,  OTTEN MARTINA DR ,  WALTER HELMUT DR ,  WESTPHALEN KARL-OTTO DR

    IPC: C07D239/54 ,  A01N43/54 ,  A01N43/647 ,  A01N43/707 ,  A01N43/74 ,  A01N43/76 ,  A01N43/78 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07F9/6558

    Abstract: The invention relates to 3-(benzazol-4-yl)pyrimidine-dione-derivatives of formula (I) and the salts thereof, whereby X = O, S; R = H, NH2, C1-C6-alkyl, C1-C6-alkyl halide; R = H, halogen, C1-C6-alkyl, C1-C6-alkyl halide, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl; R = H, halogen, C1-C6-alkyl; R = H, halogen; R = CN, halogen, C1-C6-alkyl, C1-C6-alkyl halide, C1-C6-alkoxyl, C1-C6-alkoxyl halide; =Y- = a group =N-N(R )-, =C(ZR )-N(R )-, =C(ZR )-O-, =C(ZR )-S-; R = C1-C6-alkyl, C1-C4-alkyl halide, C3-C6-cycloalkyl, C3-C6-alkenyl, C3-C6-alkynyl, C1-C6-alkyl-SO2, C1-C6-alkyl-CO, C1-C6-alkyl halide-CO, C1-C6-alkyl-CS, C1-C6-alkoxyl-CO, C1-C6-alkoxyl-CS or optionally substituted C1-C6-alkyl; Z = chemical bond, O, S, -S(O)-, -SO2-, -NH-, -N(R )-; R , R = C1-C6-alkyl, C1-C6-alkyl halide, hydroxy-C1-C4-alkyl, cyano-C1-C4-alkyl, C1-C4-alkoxyl-C1-C4-alkyl, C1-C4-alkoxyl halide-C1-C4-alkyl, C3-C4-alkenyloxyl-C1-C4-alkyl, C3-C4-alkynyloxyl-C1-C4-alkyl, C3-C8-cycloalkoxyl-C1-C4-alkyl, amino-C1-C4-alkyl, C1-C4-alkylamino-C1-C4-alkyl, di(C1-C4-alkyl)amino-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-alkylthio halide-C1-C4-alkyl, C3-C4-alkenylthio-C1-C4-alkyl, C3-C4-alkynylthio-C1-C4-alkyl, C1-C4-alkylsulfinyl-C1-C4-alkyl, C1-C4-alkylsulfinyl halide-C1-C4-alkyl, C3-C4-alkenylsulfinyl-C1-C4-alkyl, C3-C4-alkynylsulfinyl-C1-C4-alkyl, C3-C6-alkenyl, cyano-C3-C6-alkenyl, C3-C6-alkenyl halide, C3-C6-alkynyl, cyano-C3-C6-alkynyl, C3-C6-alkynyl halide, HO-CO-C1-C4-alkyl, (C1-C4-alkoxyl)CO-C1-C4-alkyl, (C1-C4-alkyl)CS-C1-C4-alkyl, H2N-CO-C1-C4-alkyl, C1-C4-alkyl-NHCO-C1-C4-alkyl, di(C1-C4-alkyl)NCO-C1-C4-alkyl, di(C1-C4-alkyl)phosphonyl-C1-C4-alkyl, optionally substituted C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl, phenyl-C1-C4-alkyl, 3- to 7-linked heterocyclyl or heterocyclyl-C1-C4-alkyl, whereby each heterocyclyl ring can contain a CO-ring link or CS-ring link, or provided that Z = chemical bond, R also H, OH, CN, SH, NH2, halogen, -CH(OH)-CH2-R , -CH(halogen)-CH2-R , -CH2-CH(halogen)-R , -CH=CH-R or -CH=C(halogen)-R , whereby R = COOH, (C1-C4-alkoxyl)carbonyl, (C1-C4-alkylthio)carbonyl, CONH2, C1-C4-alkyl-NHCO or di(C1-C4-alkyl)NCO, or R + R = an optionally substituted 1,3-propylene-, tetramethylene-, pentamethylene- or ethylene oxyethylene-chain.

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