公开(公告)号：ES2077948T3

公开(公告)日：1995-12-01

申请号：ES92115766

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE3884021T2

公开(公告)日：1994-04-14

申请号：DE3884021

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE3884021D1

公开(公告)日：1993-10-21

申请号：DE3884021

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE3884136T2

公开(公告)日：1994-04-21

申请号：DE3884136

申请日：1988-10-31

Applicant: KAO CORP

Inventor： HONMA YASUHIRO ,  MIYAZAKI NOBUO ,  MISUMI HISASHI ,  SUDA TOSHIYASU ,  AKAZAKI SHUICHI ,  MINEMATSU YOSHIHIRO ,  KAWAI MICHIO

IPC: G01N27/02 ,  A61B5/103 ,  G01N27/04 ,  A61B5/05

Abstract: This invention relates to the measurement of the moisture content retained in the skin, and enables accurate diagnosis of the skin condition by the device, which can be switched in the connection of measurement electrodes to measure the moisture content either in the surface or in the depth of the keratinous layer of the skin.

公开(公告)号：DE3884136D1

公开(公告)日：1993-10-21

申请号：DE3884136

申请日：1988-10-31

Applicant: KAO CORP

Inventor： HONMA YASUHIRO ,  MIYAZAKI NOBUO ,  MISUMI HISASHI ,  SUDA TOSHIYASU ,  AKAZAKI SHUICHI ,  MINEMATSU YOSHIHIRO ,  KAWAI MICHIO

IPC: G01N27/02 ,  A61B5/103 ,  G01N27/04 ,  A61B5/05

Abstract: This invention relates to the measurement of the moisture content retained in the skin, and enables accurate diagnosis of the skin condition by the device, which can be switched in the connection of measurement electrodes to measure the moisture content either in the surface or in the depth of the keratinous layer of the skin.

公开(公告)号：DE3854275T2

公开(公告)日：1996-04-11

申请号：DE3854275

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：DE3854275D1

公开(公告)日：1995-09-07

申请号：DE3854275

申请日：1988-03-02

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKAZAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE ,  OHTOMO TSUYOSHI ,  KOMORI TAKASHI

IPC: A61K8/42 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/00 ,  C07H15/04 ,  A61K7/48

Abstract: An external skin care preparation comprising a compound represented by the following general formula (II), or a salt thereof: General formula (II): wherein R6 and R7 mean individually an aliphatic hydrocarbon group having 10-26 carbon atoms and R8 denotes a group -CH CH OH, -CH COOH or -COCH , and further comprising a surfactant.p

公开(公告)号：ES2045061T3

公开(公告)日：1994-01-16

申请号：ES88118083

申请日：1988-10-31

Applicant: KAO CORP

Inventor： HONMA YASUHIRO ,  MIYAZAKI NOBUO ,  MISUMI HISASHI ,  SUDA TOSHIYASU ,  AKAZAKI SHUICHI ,  MINEMATSU YOSHIHIRO ,  KAWAI MICHIO

IPC: G01N27/02 ,  A61B5/103 ,  G01N27/04 ,  A61B5/05

Abstract: This invention relates to the measurement of the moisture content retained in the skin, and enables accurate diagnosis of the skin condition by the device, which can be switched in the connection of measurement electrodes to measure the moisture content either in the surface or in the depth of the keratinous layer of the skin.

公开(公告)号：JPH0624955A

公开(公告)日：1994-02-01

申请号：JP18397192

申请日：1992-07-10

Applicant: KAO CORP

Inventor： SHINPOU TSUNEO ,  KIMURA MITSUTOSHI ,  MASUDA MITSUHARU ,  SUZUKI YUJI ,  MINEMATSU YOSHIHIRO

IPC: A61K8/67 ,  A61K8/00 ,  A61K8/96 ,  A61K8/97 ,  A61Q19/00 ,  A61Q19/02 ,  A61K7/48 ,  A61K7/00

Abstract: PURPOSE:To obtain a beautifying and whitening cosmetic capable of preventing and treating dermal stains and ephelides by sunburn, etc., due to its excellent beautifying and whitening effects on the skin. CONSTITUTION:This beautifying and whitening cosmetic comprises (A) one or two or more selected from the group consisting of L-ascorbic acid and water- soluble derivatives thereof and (B) an extract from Caryophyllus.

公开(公告)号：JPS63216812A

公开(公告)日：1988-09-09

申请号：JP5127687

申请日：1987-03-06

Applicant: KAO CORP

Inventor： YANO SHINJI ,  KAWAMATA AKIRA ,  MINEMATSU YOSHIHIRO ,  AKASAKI SHUICHI ,  ZAMA MITSUKO ,  IMOKAWA GENJI ,  TAKAISHI NAOTAKE

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61K8/68 ,  A61K31/22 ,  A61P17/00 ,  A61Q5/00 ,  A61Q19/00 ,  C07C233/18 ,  C07C233/20 ,  C07H15/04

Abstract: PURPOSE:To obtain a skin drug for external use, containing a specific amide derivative, capable of enhancing moisture holding power of keratinous layers and exhibiting excellent improving and preventive effects on roughening of the skin. CONSTITUTION:A skin drug for external use obtained by containing a compound expressed by formula I (R is 10-26C hydrocarbon group; R is 9-25C hydrocar bon group; n is 3-6), e.g. N-(2-hydroxyl-3-hexadecyloxypropyl)-N-3-hydroxy propylhexadacanamide, in an amount of 0.001-50wt.%, preferably 0.1-20wt.% based on the total composition. Effects are further increased by additionally blending 0.01-20wt.% preferably 0.1-5wt.% surfactant, particularly nonionic surfactant. The compound expressed by formula I is prepared by reacting a glycidyl ether expressed by formula II with an amino-alcohol expressed by formula III and then selectively acylating the amino group of the resultant compound expressed by formula IV.