公开(公告)号：JP2002322150A

公开(公告)日：2002-11-08

申请号：JP2002073851

申请日：2002-03-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94

Abstract: PROBLEM TO BE SOLVED: To provide a compound which exerts a useful pharmacological characteristic toward melatoninergic receptors. SOLUTION: The compound represented by formula (I), not including indeno[1,2-b]indol-10(5H)-one, is provided [wherein, R is H or an arbitrarily substituted alkenyl or an alkyl group; R1 , R2 , R3 , R4 , R5 , R6 , R7 and R8 are each H, an alkyl, an alkenyl, a hydroxy, an alkoxy, an alkenyloxy, an arylalkyl, an arylalkoxy, a carboxy, an acyloxy or an arylcarbonyloxy group, or one of R1 to R8 groups forms an alkylenedioxy group with a group adjacent to the one of R1 to R8 ]. In the compound, when R is not H, at least one of R1 to R8 groups is a hydroxy or an acyloxy group.

公开(公告)号：JP2002265469A

公开(公告)日：2002-09-18

申请号：JP2002065233

申请日：2002-03-11

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04

Abstract: PROBLEM TO BE SOLVED: To provide a medicine which contains a compound having high affinity with a melatonin receptor and is useful for treating diseases related to the melatonin operation system. SOLUTION: The compound represented by the formula (R1 , R2 , R3 , R4 , R5 , R6 , and R8 are each H or the like, R7 is H or the like, or one of R1 to R8 forms a 1 to 2C alkylenedioxy together with another adjacent one of R1 to R8 ), its optically isomer (when the optical isomer exists), and its pharmacologically acceptable acid or base adduct; a process for preparing the same; and a pharmaceutical composition containing the same.

公开(公告)号：FR2929276B1

公开(公告)日：2010-04-23

申请号：FR0801779

申请日：2008-04-01

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61K31/7048 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07H15/26

公开(公告)号：ES2363196T3

公开(公告)日：2011-07-26

申请号：ES09290237

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

Abstract: Compuesto de fórmula (I): **Fórmula** donde R1, R2 y R3, idénticos o diferentes, representan cada uno un átomo de hidrógeno o un grupo de Fórmula (A): **Fórmula**

公开(公告)号：DK2107055T3

公开(公告)日：2011-06-27

申请号：DK09290237

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS ,  VERBEUREN TONY

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

公开(公告)号：FR2929276A1

公开(公告)日：2009-10-02

申请号：FR0801779

申请日：2008-04-01

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61K31/7048 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07H15/26

Abstract: Composés de formule (I) : dans laquelle R1, R2 et R3, identiques ou différents, représentent chacun un atome d'hydrogène ou le groupement de formule (A) : Médicaments.

公开(公告)号：FR2882654B1

公开(公告)日：2007-04-27

申请号：FR0502044

申请日：2005-03-01

Applicant: SERVIER LAB

Inventor： VERBEUREN TONY ,  RUPIN ALAIN ,  SANSILVESTRI MOREL PATRICIA ,  VALLEZ MARIE ODILE ,  BOUSSARD MARIE FRANCOISE ,  WIERZBICKI MICHEL

IPC: A61K31/352 ,  A61P7/02

Abstract: Use of diosmetin compounds in obtaining pharmaceutical compositions intended for the prevention and/or treatment of thrombotic pathologies and pathologies with a risk of thrombosis.

公开(公告)号：FR2821843B1

公开(公告)日：2003-05-09

申请号：FR0103293

申请日：2001-03-12

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04 ,  A61K31/404

Abstract: Compound of formula (I):wherein:R1, R2, R3, R4, R5, R6 and R8, which may be identical or different, each represents hydrogen, alkyl, arylalkyl, hydroxy, alkoxy, arylalkoxy, acyloxy, arylcarbonyloxy, carboxyalkyl or carboxy,R7 represents hydrogen, hydroxy, alkoxy, arylalkoxy, acyloxy or arylcarbonyloxy group,or one of R1 to R8, together with another of R1 to R8 adjacent to it, forms an alkylenedioxy,its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base.

公开(公告)号：FR2826009A1

公开(公告)日：2002-12-20

申请号：FR0107718

申请日：2001-06-13

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  ROUSSEAU ANNE ,  ATASSI GHANEM ,  HICKMAN JOHN ,  PIERRE ALAIN ,  LEONCE STEPHANE ,  GUILBAUD NICOLAS ,  KRAUS BERTHIER LAURENCE

IPC: C07D209/80 ,  A61K31/403 ,  A61K31/433 ,  A61K31/4439 ,  A61P35/00 ,  C07D209/94 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D491/04 ,  C07D491/056 ,  C07D405/14 ,  C07D403/12 ,  A61K31/4045 ,  A61K31/4402 ,  A61K31/4453

Abstract: Indenoindolone derivatives (I), their isomers and salts with acids and bases are new. Indenoindolone derivatives (I), their isomers and salts with acids and bases are new; R = H, alkyl (optionally substituted by carboxy, alkoxycarbonyl, or NR10R11), or alkenyl; R1-R8 = H, alkyl (optionally substituted by aryl, carboxy or alkoxycarbonyl), OH, acyloxy, NR12R13, carboxy, alkoxy (optionally substituted by aryl or NR14R15), alkenyloxy, or to adjacent groups R1-R8 = 1 or 2C alkylenedioxy; R9 = H, aryl, heteroaryl or alkyl (optionally containing one or more unsaturations and optionally substituted by one or more aryl, heteroaryl, 3-8C cycloalkyl, CN, or NR17R18 groups); X = O or NR16; R10, R11, R14, R15, R17, R18 = alkyl; NR10+R11, NR14+R15, NR17+R18 = nitrogen heterocycle; R12, R13 = H, alkyl, or NR14R15; R16 = H, alkyl, aryl, or aryl alkyl. Where alkyl, alkoxy, acyloxy, alkenyl and alkenyloxy groups have up to 6 C atoms, aryl is defined as phenyl, biphenyl, or naphthyl (optionally substituted by one or more halogen, alkyl, alkenyl, alkoxy, phenoxy, nitro, CN, amino, mono- and di-alkylamino or 1-2C alkylenedioxy groups) and heteroaryl groups may be mono- or bicyclic of 5-12 members with 1-3 heteroatoms (O, N, S) and optionally substituted by halogen, alkyl, OH, alkoxy, polyhaloalkyl, amino, mono- and di-alkylamino groups, and nitrogen heterocycles are monocyclic having 5-7 members including 1-3 heteroatoms, one of which is N and the others may be O, N, or S. An Independent claim is also included for the preparation of (I).

公开(公告)号：GEP20115342B

公开(公告)日：2011-12-12

申请号：GEAP2009011185

申请日：2009-03-25

Applicant: SERVIER LAB

Inventor： SANSILVESTRI-MOREL PATRICIA ,  WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12

Abstract: Compounds of the formula (I), (I) wherein R1, R2 and R3 have the values indicated in the claims; a method for its production and use thereof for prevention or treatment of chronic vein diseases.