公开(公告)号：WO2021247386A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/034700

申请日：2021-05-28

Applicant: RCE TECHNOLOGIES, INC.

Inventor： TITUS, Jitto ,  BURMAN, Atandra

IPC: A61B5/024 ,  A61B5/1455 ,  G01N21/33 ,  G01N21/35 ,  G01N21/49 ,  A61B2562/0238 ,  A61B5/14546 ,  A61B5/1495 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/108 ,  G01J3/42 ,  G01N21/552 ,  G01N2201/0221 ,  G01N2201/0696

Abstract: Transdermal optical sensing systems and methods of use are described. The systems include a main body, an internal reflection element arranged within the main body, with an internal reflection element surface exposed for contact with an epidermis, an optical source configured to project light into the internal reflection element, an optical detector arranged to detect reflected light that reflects internally within the internal reflection element from the internal reflection element surface, a controller configured to measure the light at the optical detector to determine the presence of one or more compounds within the epidermis, and a retention member attached to the main body, the retention member configured to wrap about a wrist of a patient.

公开(公告)号：WO2021245374A1

公开(公告)日：2021-12-09

申请号：PCT/GB2021/051280

申请日：2021-05-26

Applicant: KING'S COLLEGE LONDON

Inventor： VERCAUTEREN, Tom ,  EBNER, Michael ,  XIE, Yijing ,  NABAVI, Eli

IPC: G01J3/28 ,  G01J3/02 ,  A61B1/00 ,  A61B5/00 ,  G06T5/00 ,  G01J3/12 ,  H04N9/04 ,  A61B1/00009 ,  A61B5/0075 ,  G01J2003/1217 ,  G01J2003/283 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/2823 ,  H04N5/332 ,  H04N9/04515 ,  H04N9/04559

Abstract: Embodiments of the invention provide a method and system that allows parameters of a desired target image to be determined from hyperspectral imagery of scene. The parameters may be representative of various aspects of the scene being imaged, particularly representative of physical properties of the scene. For example, in some medical imaging contexts, the property being imaged may be blood perfusion or oxygenation saturation level information per pixel. In one embodiment the parameters are obtained by collecting lower temporal and spatial resolution hyperspectral imagery, and then building a virtual hypercube of the information having a higher spatial resolution using a spatiospectral aware demosaicking process, the virtual hypercube then being used for estimation of the desired parameters at the higher spatial resolution. Alternatively, in another embodiment, instead of building the virtual hypercube and then performing the estimation, a joint demosaicking and parameter estimation operation is performed to obtain the parameters. Various white level and spectral calibration operations may also be performed to improve the results obtained. While establishing functional and technical requirements of an intraoperative system for surgery, we present iHSI system embodiments that allows for real-time wide-field HSI and responsive surgical guidance in a highly constrained operating theatre. Two exemplar embodiments exploiting state-of-the-art industrial HSI cameras, respectively using linescan and snapshot imaging technology, were investigated by performing assessments against established design criteria and ex vivo tissue experiments. We further report the use of one real-time iHSI embodiment during an ethically-approved in-patient clinical feasibility case study as part of a spinal fusion surgery therefore successfully validating our assumptions that our invention can be seamlessly integrated into the operating theatre without interrupting the surgical workflow.

公开(公告)号：WO2021148771A1

公开(公告)日：2021-07-29

申请号：PCT/GB2021/000004

申请日：2021-01-19

Applicant: THE SECRETARY OF STATE FOR DEFENCE

Inventor： McEWAN, Kenneth, John

IPC: G01J3/02 ,  F41G11/00 ,  G01J3/28 ,  G01J3/44 ,  G01N21/65 ,  H04N5/3745 ,  G01J3/0202 ,  G01J3/2803 ,  G01N2021/1793 ,  G01N2201/0697

Abstract: Apparatus for stand-off Raman spectroscopy, comprising optical imaging device (e.g. a sight, e.g. of a rifle), Laser, Optical apparatus (optionally in the form of an adapter) with a wavelength band filter and optical dispersion means (e.g. grating) to disperse a Raman spectrum to an image sensor, and focusing means wherein the laser is a pulsed laser, and each of the detector elements of the array comprises a frequency band pass filter for detecting light pulses in preference to background radiation. Each detector element is provided with a first charge storage element to store charge, connected via a frequency band pass filter to a second charge storage element arranged to store charge preferentially resulting from high frequency light pulses. This may be performed in the short wave infrared spectrum. The image sensor can also have conventional detector elements, enabling viewing of a scene whilst simultaneously obtaining a Raman spectrum of a target in the scene. Advantageously this may be implemented in a rifle sight, optionally by means of an adapter arranged so that the rifle sight can be readily switched from conventional viewing mode to stand off Raman spectroscopy mode.

公开(公告)号：WO2021250537A1

公开(公告)日：2021-12-16

申请号：PCT/IB2021/054963

申请日：2021-06-07

Applicant: TÜBİTAK

Inventor： KILIÇ, Cihan ,  GÜLMEZ, Yakup ,  ÖZKAN, Turgay ,  TAKAOĞLU, Faruk ,  ATAY, Merve ,  KAYILLIOĞLU, Oğuz ,  ATAY, Bilal ,  DALKILIÇ, Emre ,  ÇETİN, Yücel ,  ARDIÇ, Emre

IPC: G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0248

Abstract: The invention can use different types of illumination sources to obtain radiation in the 250-1100nm wavelength range that includes a part of the visible, ultraviolet and infrared region of the electromagnetic spectrum, without the need for any external intervention, as a result of the moving illumination panels, the open frame stage, and the moving imaging system, It is related to a spectroscopic, hyperspectral and digital imaging device that provides the measurement of the energy of the light reflected from the surface of the object at different wavelengths by being homogeneously and strongly illuminated from all possible aspect and directions of the object subject to examination. The device in question basically includes; a movable floor table on which the object to be examined is placed and can be easily disassembled and installed thanks to the socketed structure of the vacuum module, which functions to fix the object to the floor and smooth its surface depending on the need, movable illumination panels that enable the use of different types of illumination sources for different wavelengths in the desired combination and number, and to adjust the angle of incidence of the light to the object to be examined at the time of examination with its mobility in horizontal and vertical axis; spectroscopic measurement module which contains the spectrometer optical fiber tips arranged in the probe tip are brought closer to the object surface to a distance of 1 mm to the surface of the object to be examined and positioned accurately to the target point to be measured by endoscopic cameras, thus enabling measurement with high accuracy and precision, free from interference effects and noise-free; colorful and monochrome camera modules, a lens system with high optical zooming capacity, a linear optical filter and a moving imaging system with motion mechanisms that ensure their alignment with each other. Spectral information of each pixel in images obtained using many narrow wavelength bands is processed using hyperspectral image analysis methods, pattern recognition algorithms, machine learning, and deep learning algorithms in a computer to which the device is connected, and extracting the desired information from the images, identifying and classifying the object and anomaly (contradiction) can be detected.

公开(公告)号：WO2021198562A1

公开(公告)日：2021-10-07

申请号：PCT/FI2021/050228

申请日：2021-03-30

Applicant: TEKNOLOGIAN TUTKIMUSKESKUS VTT OY

Inventor： HOLMLUND, Christer ,  KESKISAARI, Aki ,  STUNS, Ingmar ,  TOIVANEN, Hans

IPC: G01J3/02 ,  G01J3/26 ,  G02B26/00 ,  G01J3/0202 ,  G02B26/001 ,  G02B26/0833

Abstract: A Fabry-Perot interferometer (300) comprises: - a first mirror plate (100) comprising a first semi-transparent mirror (M1), - a second semi-transparent mirror (M2) to define an optical cavity together with the first mirror (M1), and - one or more first supporting elements (S1) to support the first mirror plate (100), wherein the first mirror plate has a first substantially planar surface (SRF11) and a second substantially planar surface (SRF12) defining the maximum thickness (h100) of the first mirror plate (100), wherein the first mirror plate (100) is bonded to the one or more first supporting elements (S1) by three or more joints (J1), wherein each joint (J1) is bonded to the first mirror plate (100) at a bonding region (REG1), wherein the distance (d1) between each bonding region (REG1) and the first substantially planar surface (SRF11) is greater than 30% of the thickness (h100) of the mirror plate (100), and the distance (d2) between each bonding region (REG1) and the second substantially planar surface (SRF12) is greater than 30% of the thickness (h100) of the mirror plate (100).