公开(公告)号：WO2015043623A1

公开(公告)日：2015-04-02

申请号：PCT/EP2013/069899

申请日：2013-09-25

Applicant: FOSS ANALYTICAL A/S ,  UNIVERSITY OF COPENHAGEN

Inventor： CARSTENSEN, Andreas ,  FRYDENVANG, Jens ,  HUSTED, Søren ,  MAARSCHALKERWEERD, Marie van

IPC: G01N21/64 ,  G01N21/84

CPC classification number: G01N21/6408 ,  G01N21/6486 ,  G01N33/0098 ,  G01N33/4833 ,  G01N2021/8466 ,  G01N2201/062 ,  G01N2201/12

Abstract: A method and an instrument for determining a nutritional state of a plant with respect to one or more nutrients is provided. The method comprises the steps of recording a time series of a fluorescence induction signal of a tissue sample of the plant using a fluorometer device to obtain signal data, wherein the time series at least comprises signal data within the rising portion of the fluorescence induction signal, and determining the nutritional state from an empirical model applied to the signal data, wherein the empirical model is based on pre-recorded reference data and relates nutritional states to shape-related features in the progression of the fluorescence induction signal.

Abstract translation: 提供了一种用于确定植物相对于一种或多种营养物质的营养状态的方法和仪器。 该方法包括以下步骤：使用荧光计装置记录植物的组织样本的荧光诱导信号的时间序列以获得信号数据，其中所述时间序列至少包括荧光感应信号的上升部分内的信号数据， 以及从应用于信号数据的经验模型确定营养状态，其中所述经验模型基于预先记录的参考数据，并将营养状态与荧光感应信号进展中的形状相关特征相关联。

公开(公告)号：WO2014146719A1

公开(公告)日：2014-09-25

申请号：PCT/EP2013/056091

申请日：2013-03-22

Applicant: FOSS ANALYTICAL A/S

Inventor： ELSOEE, Maja Kirstine ,  JUHL, Henrik Vilstrup ,  NIKOLAJSEN, Thomas

IPC: G01N21/35 ,  G01N21/71 ,  G01J3/443 ,  G01N33/24

CPC classification number: G01N21/3563 ,  G01J3/28 ,  G01J3/443 ,  G01J2001/083 ,  G01N1/286 ,  G01N21/35 ,  G01N21/718 ,  G01N33/24 ,  G01N2201/129

Abstract: A system (102) for determining properties of a sample (114) comprises a LIBS detector (104,106) and an infra-red absorption detector (108,110) for interrogating a sample (114) to generate LIBS spectral data and infra-red absorption spectral data respectively; and a data processor (112) adapted to apply at least one chemometric prediction model, each constructed to link, preferably quantitatively link, features of both LIBS and absorption spectral data to a different specific property of the sample, to a combined dataset derived from at least portions of both the LIBS and the absorption data to generate therefrom a determination, preferably a quantitative determination, of the specific property linked by that model.

Abstract translation: 用于确定样品（114）的性质的系统（102）包括用于询问样品（114）以产生LIBS光谱数据和红外吸收光谱数据的LIBS检测器（104,106）和红外吸收检测器（108,110） 分别; 以及适于应用至少一个化学计量预测模型的数据处理器（112），每个化学计量预测模型被构造为将LIBS和吸收光谱数据的特征优选地定量地链接到样本的不同特定属性， LIBS和吸收数据的最少部分由此产生由该模型链接的特定属性的确定，优选地定量确定。

公开(公告)号：WO2013156081A1

公开(公告)日：2013-10-24

申请号：PCT/EP2012/057290

申请日：2012-04-20

Applicant: FOSS ANALYTICAL A/S ,  BISGAARD, Christer ,  LAURELL, Thomas ,  GRENVALL, Carl ,  ANTFOLK, Christian

Inventor： BISGAARD, Christer ,  LAURELL, Thomas ,  GRENVALL, Carl ,  ANTFOLK, Christian

IPC: G01N15/12

CPC classification number: G01N27/02 ,  G01N15/12 ,  G01N2015/1062 ,  G01N2015/1236 ,  G01N2015/142

Abstract: A microfluidic impedance flow cytometer ('MIC') device (2) comprises a substrate (4) in which is formed at least one flow channel (6) for leading through a particle (22) containing fluidic sample. The flow channel (6) is formed with a focusing zone (12) and a measurement zone (14) located downstream of the focusing zone (12) in the direction of through flow and provided with an electrode arrangement (18) for characterising particles (22) in the flowing fluidic sample by means of electrical impedance wherein an acoustophoretic particle focusing arrangement (20) is provided in acoustic coupling to the flow channel (6) in the focusing zone (12) to induce acoustic forces in fluid in the flow channel (6) so as to effect a lateral and/or vertical focusing of particles before flowing to the measurement zone (14).

Abstract translation: 微流体阻流流式细胞仪（“MIC”）装置（2）包括衬底（4），其中形成有至少一个用于引导含有流体样品的颗粒（22）的流动通道（6）。 流动通道（6）形成有聚焦区域（12）和位于聚焦区域（12）的下游的测量区域（14），该测量区域沿着流动方向设置有用于表征颗粒的电极装置（18） 22）在流动的流体样品中通过电阻抗，其中在聚焦区域（12）中声学耦合到流道（6）提供声学粒子聚焦装置（20）以在流动通道中引起流体中的声力 （6），以便在流入测量区域（14）之前实现颗粒的横向和/或垂直聚焦。

公开(公告)号：WO2013113388A1

公开(公告)日：2013-08-08

申请号：PCT/EP2012/051729

申请日：2012-02-02

Applicant: FOSS ANALYTICAL A/S ,  BÜCHMANN, Bo ,  GREGERSEN, Poul

Inventor： BÜCHMANN, Bo ,  GREGERSEN, Poul

IPC: G05B13/04

CPC classification number: G05B13/048

Abstract: A method of controlling a production process including a process step for the morphological modification of a bio-material matrix comprises obtaining digital input data acquired during each of a plurality of production runs of the process, which input data includes information from radiation within a portion of the electromagnetic or acoustic spectrum having interacted with the matrix at one or more locations within the process together with a process control parameter and production event data for the associated production run; generating in a computer a prediction model from a multivariate analysis of the digital input data, which model links the information directly with one or more of process control parameters, production run events and process control settings; and applying in the computer the prediction model to interacted information obtained from a new production run to generate as an output one or more of a process control parameter a process control event and a predicted production run event for the new production run for use in controlling the production process.

Abstract translation: 一种控制生产过程的方法，包括用于生物材料矩阵的形态修饰的处理步骤，包括获得在该过程的多个生产运行期间的每一个期间获取的数字输入数据，该输入数据包括来自 电磁或声谱与过程中的一个或多个位置处的矩阵相互作用，以及用于相关联的生产运行的过程控制参数和生产事件数据; 在数字输入数据的多变量分析中，在计算机中生成预测模型，该模型直接将信息与过程控制参数，生产运行事件和过程控制设置中的一个或多个进行链接; 以及在所述计算机中将所述预测模型应用于从新的生产运行获得的交互信息，以生成作为输出的过程控制参数的一个或多个过程控制事件和用于控制所述新生产运行的新生产运行的预测生产运行事件 生产过程。

公开(公告)号：WO2013056726A1

公开(公告)日：2013-04-25

申请号：PCT/EP2011/068117

申请日：2011-10-17

Applicant: FOSS ANALYTICAL A/S ,  JUHL, Henrik Vilstrup

Inventor： JUHL, Henrik Vilstrup

IPC: G01J3/45

CPC classification number: G01J3/45 ,  G01J2003/283

Abstract: A method of compensating for frequency drift of a reference energy source in an FT interferometer based spectrometer instrument having an arithmetic unit into which has been obtained data representing a reference interferogram (40) collected in response to a trigger signal having been generated in dependence on the emission frequency of the reference energy source and data representing a target interferogram (42) recorded by the FT interferometer in response to a trigger signal also having been generated in dependence on the emission frequency of the reference energy source in the same manner. The method further comprises the comparing in the arithmetic unit the data representing the reference interferogram (40) and the data representing the target interferogram (42) to determining a phase shift (d) between the interferograms in a window W in at least one region (36) away from center-burst (44) and generating in the arithmetic unit a mathematical transform dependent on the determined shift or shifts (d) to be subsequently applied to control the operation of the spectrometer instrument in order to generate data representing a frequency stabilized interferogram of an unknown sample recorded by the FT interferometer.

Abstract translation: 一种在具有算术单元的基于FT干涉仪的光谱仪器中补偿参考能量源的频率漂移的方法，其中已经获得表示根据已经根据所述基准干涉仪产生的触发信号而收集的参考干涉图（40）的数据 参考能量源的发射频率和由FT干涉仪记录的响应于也以相同方式根据参考能量源的发射频率产生的触发信号的目标干涉图（42）的数据。 该方法还包括在运算单元中比较表示参考干涉图（40）的数据和表示目标干涉图（42）的数据，以确定至少一个区域中的窗口W中的干涉图之间的相移（d） 36）远离中心突发（44）并且在算术单元中产生依赖于所确定的移位或移位（d）的数学变换，以便随后应用于控制光谱仪器的操作，以便产生表示频率稳定的数据 由FT干涉仪记录的未知样品的干涉图。

公开(公告)号：WO2012150172A1

公开(公告)日：2012-11-08

申请号：PCT/EP2012/057631

申请日：2012-04-26

Applicant: FOSS ANALYTICAL A/S ,  FOLKENBERG, Jacob ,  LARSEN, Hans

Inventor： FOLKENBERG, Jacob ,  LARSEN, Hans

IPC: G01B9/02 ,  G01J3/453

CPC classification number: G01J3/45 ,  G01J3/4535

Abstract: A spectrometric instrument (38) comprising: a scanning interferometer (40,42,44) having a beamsplitter (40) for dividing incident optical radiation into a reflected beam, following a reflected beam path and a transmitted beam following a transmitted beam path; a monochromatic optical radiation source (52) for launching a reference beam into the interferometer (40,42,44) along a first propagation path (62) to be initially incident on a first face (40') of the beamsplitter (40); an observation optical radiation source (46) for launching a divergent observation beam (64) into the interferometer (4,6,8) along a second propagation path (66) to be initially incident on the first face (40') of beamsplitter (40) and overlap the reference beam at the first face (40'); wherein the radiation sources (52;46) cooperate to generate a first angle (θ) between the directions of propagation of the two beams along respective first (62) and second (66) propagation paths when initially and simultaneously incident at the first face (40') which is larger than a divergence half-angle (α) of the observation beam 64.

Abstract translation: 一种光谱仪器（38），包括：扫描干涉仪（40,42,44），具有分束器（40），用于将入射光辐射分成反射光束，跟随反射光束路径和发射光束跟随传输光束路径; 用于沿着第一传播路径（62）将参考光束发射到干涉仪（40,42,44）中以最初入射在分束器（40）的第一面（40'）上的单色光辐射源（52）; 观察光辐射源（46），用于沿着第二传播路径（66）将发散观察光束（64）发射到干涉仪（4,6,8）中，以最初入射到分束器的第一面（40'） 40）并且在所述第一面（40'）处与所述参考光束重叠; 其中所述辐射源（52; 46）协作以在最初和同时入射在所述第一面处时沿着相应的第一（62）和第二（66）传播路径在所述两个光束的传播方向之间产生第一角度（θ） 40'），其大于观察光束64的发散半角（a）。

公开(公告)号：WO2012072106A1

公开(公告)日：2012-06-07

申请号：PCT/EP2010/068483

申请日：2010-11-30

Applicant: FOSS ANALYTICAL A/S ,  THOMSEN, Henrik

Inventor： THOMSEN, Henrik

IPC: G01N21/35 ,  C12G1/04 ,  G01N33/00 ,  G01N33/14

CPC classification number: G01N21/59 ,  G01N21/3504 ,  G01N33/0042 ,  G01N33/146 ,  Y02A50/248

Abstract: A system for the measurement of free and bound SO 2 in a liquid beverage product sample comprising a sample container (10) having a volume sufficient to provide a headspace (14) above the sample (12) into which a gas can pass; a gas flow system (6) adapted to extract gas from the headspace (14) and recirculating it back into the liquid volume (12); a measurement system (4) configured to monitor a time dependent evolution of SO 2 in gas from the gas flow system (6); and a dosing apparatus (8) fluidly connected to the container (10) to supply an hydrolysis reagent thereto. A heater unit (3) is provided for supplying thermal radiation into the container (10) to elevate the temperature of sample therein sufficient to facilitate the hydrolysis reaction and a signal processor (30) operates to deconvolute the monitored evolution to generate an indication of the concentration of each of the free SO 2 and the total SO 2 content of the sample.

Abstract translation: 一种用于测量液体饮料产品样品中的游离和结合的SO 2的系统，其包括样品容器（10），其具有足以提供气体可以通过的样品（12）上方的顶部空间（14）的体积; 适于从顶部空间（14）提取气体并将其再循环回到液体体积（12）中的气体流动系统（6）; 测量系统（4），其被配置为监测来自所述气体流动系统（6）的气体中SO 2的时间依赖性演化; 以及流体连接到容器（10）以向其提供水解试剂的计量装置（8）。 提供加热器单元（3），用于将热辐射提供到容器（10）中以提升其中的样品的温度，足以促进水解反应，并且信号处理器（30）操作以对所监视的进化进行解卷积，以产生 样品中游离SO2和SO2含量的浓度。

公开(公告)号：WO2012052046A1

公开(公告)日：2012-04-26

申请号：PCT/EP2010/065615

申请日：2010-10-18

Applicant: FOSS ANALYTICAL A/S ,  HOLM, Claus

Inventor： HOLM, Claus

IPC: G01N33/50 ,  G01N33/569

CPC classification number: C12Q1/06 ,  G01N33/5047 ,  G01N33/5091 ,  G01N33/582 ,  G01N2800/365

Abstract: A method for determining a degree of infection comprising the steps of i) preparing an un-isolated sample by adding a differentiating marker, suitably a meta-chromatic stain such as, for example, acridine orange to mammalian milk in an amount sufficient to provide a differentiation between cell types; ii) measuring a differential somatic cell count on the sample by means of a cytometer having a detection system sensitive to differences in the differentiating marker resulting from the marker becoming differently associated with different cell types in the sample; and iii) determining an indication of a degree of infection dependent on the measured differential cell count.

Abstract translation: 一种用于确定感染程度的方法，包括以下步骤：i）通过向哺乳动物乳添加适当的元色标记（例如吖啶橙）来制备未分离的样品，其量足以提供 细胞类型之间的分化; ii）通过具有检测系统的血细胞计数器来测量样品上的差异体细胞计数，所述检测系统对由所述标记变异与所述样品中的不同细胞类型不同相关的差异标记的差异敏感; 以及iii）确定取决于测量的差异细胞计数的感染程度的指示。

公开(公告)号：WO2010040394A1

公开(公告)日：2010-04-15

申请号：PCT/EP2008/063434

申请日：2008-10-08

Applicant: FOSS Analytical A/S ,  HOLM, Claus ,  FOLKENBERG, Jacob Riis ,  GRENVALL, Carl Johan ,  LAURELL, Lars Thomas ,  AUGUSTSSON, Per

Inventor： HOLM, Claus ,  FOLKENBERG, Jacob Riis ,  GRENVALL, Carl Johan ,  LAURELL, Lars Thomas ,  AUGUSTSSON, Per

IPC: B01D43/00 ,  B01L3/00

CPC classification number: B01D21/283 ,  B01L3/502761 ,  B01L2300/0816 ,  B01L2300/0877 ,  C12M47/06 ,  G01N15/12 ,  G01N15/1459 ,  G01N33/06

Abstract: The invention relates to a device for manipulation of particles (30) in a sample liquid (32) said device comprising a source of ultrasound (16) capable of emitting ultrasound with a given wavelength, an inlet for a sample liquid (2), one or more outlets (4, 5, 6) and a compartment (14), being dimensioned to support a standing ultrasonic wave (40) of said wavelength, characterised in that the device further comprises an inlet for sheath liquid (1, 3) configured to direct a sheath liquid (34) to extend substantially in parallel to an anti-node plane (46) of the ultrasonic standing wave (40) proximate to a sheathed compartment wall. Specifically the device may be used in combination with a particle enumeration device for enumeration of somatic cells in milk.

Abstract translation: 本发明涉及一种用于操纵样品液体（32）中的颗粒（30）的装置，所述装置包括能够发射具有给定波长的超声波的超声波源（16），用于样品液体的入口（2），一个 或多个出口（4,5,6）和隔室（14），其尺寸被设计成支撑所述波长的立式超声波（40），其特征在于，所述装置还包括用于鞘液（1,3）的入口配置 引导护套液体（34）基本上平行于超声波驻波（40）的靠近护套隔室壁的反节点平面（46）延伸。 具体地，该装置可以与用于计数牛奶中体细胞的颗粒计数装置组合使用。

公开(公告)号：WO2009149766A1

公开(公告)日：2009-12-17

申请号：PCT/EP2008/057480

申请日：2008-06-13

Applicant: FOSS ANALYTICAL A/S ,  BROE BENDTSEN, Anders ,  WEIMANN, Johan ,  KJÆR ANDERSEN, Steen

Inventor： BROE BENDTSEN, Anders ,  WEIMANN, Johan ,  KJÆR ANDERSEN, Steen

IPC: C12M1/34 ,  C12M1/36

CPC classification number: C12M41/26 ,  C12M21/12 ,  C12M41/32

Abstract: A biotechnological process for conversion of a raw material (100, 200) to a desired product (130, 230) by means of one or more biological or biochemical agents (102, 104, 202) such as microorganisms and/or enzymes characterised in that the amount of one or more of said biological or biochemical agents (102, 104, 202) is controllable by a process control algorithm (124,224) dependent on one or more values of interest related to a process stream. A specific aspect of the invention is the use of a process control algorithm for controlling enzyme addition in biofuel production by fermentation of biomass to alcohols.

Abstract translation: 一种用于通过一种或多种生物或生物化学试剂（102,104,202）（例如微生物和/或酶）将原料（100,200）转化为所需产物（130,230）的生物技术方法，其特征在于 所述生物或生物化学试剂（102,104,202）中的一种或多种的量可通过依赖于与工艺流相关的一个或多个感兴趣值的过程控制算法（124,224）来控制。 本发明的一个具体方面是使用过程控制算法来控制生物燃料生产中通过发酵生物质到醇的酶添加。