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    MOLECULAR MANIPULATION SYSTEM AND METHOD
    91.
    发明申请
    MOLECULAR MANIPULATION SYSTEM AND METHOD 审中-公开
    分子操作系统和方法

    公开(公告)号：WO2014200341A1

    公开(公告)日：2014-12-18

    申请号：PCT/NL2014/050377

    申请日：2014-06-11

    Applicant: STICHTING VU-VUMC

    Inventor： PETERMAN, Erwin Johannes Gerard ,  WUITE, Gijs Jan Lodewijk ,  SITTERS, Gerrit ,  KAMSMA, Douwe

    IPC: G02B21/32 ,  B82Y35/00

    CPC classification number: C12Q1/6837 ,  G01N29/0681 ,  G02B21/32

    Abstract: A molecular manipulation system for investigating molecules,having a sample holder constructed to hold a sample comprising a plurality of molecules attached on one side to a surface in the sample holder and on another side attached to a microbead of a plurality of microbeads. The system having; an acoustic wave generator to generate an acoustic wave exerting a force on the microbeads in the sample; anda detector device to detect a response of the plurality of microbeads in the sample on the force exerted by the acoustic wave to investigate the molecules attached to the microbeads.

    Abstract translation: 一种用于调查分子的分子操纵系统，具有样品架，其被构造成将包含附着在一侧的多个分子的样品保持在样品保持器中的表面上，另一侧附着在多个微珠的微珠上。 系统有 声波发生器，用于产生在样品中的微珠上施加力的声波; 以及检测器装置，用于检测样品中的多个微珠对由声波施加的力的响应，以研究附着于微珠的分子。

    METHOD AND SYSTEM FOR IMAGING A MOLECULAR STRAND
    92.
    发明申请
    METHOD AND SYSTEM FOR IMAGING A MOLECULAR STRAND 审中-公开
    用于成像分子条的方法和系统

    公开(公告)号：WO2014196854A1

    公开(公告)日：2014-12-11

    申请号：PCT/NL2014/050351

    申请日：2014-06-02

    Applicant: STICHTING VU-VUMC

    Inventor： WUITE, Gijs Jan Lodewijk ,  PETERMAN, Erwin Johannes Gerard ,  HELLER, Iddo ,  SITTERS, Gerrit ,  CANDELLI, Andrea ,  HELL, Stefan Walter

    IPC: G01N21/64 ,  G02B21/00 ,  G02B21/16 ,  G02B21/32 ,  B01L3/00 ,  C12Q1/68

    CPC classification number: G01N21/6428 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0877 ,  B01L2400/0454 ,  C12Q1/6816 ,  G01N21/6458 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/16 ,  G02B21/32 ,  C12Q2565/629

    Abstract: The present disclosure concerns a method and system for imaging a molecular strand (MS). The method comprises providing a sample volume (SV) comprising the strand (MS); providing an excitation beam (EB) having an excitation focus (EF) in the sample volume (SV); scanning the excitation focus (EF) in the sample volume (SV) along a one dimensional scanning line (SL); trapping an end of the strand (MS) in the sample volume (SV) and extending the strand (MS) along a one-dimensional trapping line (LL) parallel to the scanning line (SL); aligning the trapping line (LL) to coincide with the scanning line (SL) to have the scanning excitation focus (EF) coincide with the strand (MS); and recording the fluorescence response (FR) as a function of a plurality of distinct scanning positions (X0) of the excitation focus (EF) along the scanning line (SL).

    Abstract translation: 本公开涉及用于使分子链（MS）成像的方法和系统。 该方法包括提供包含链（MS）的样品体积（SV）; 提供在样本体积（SV）中具有激发焦点（EF）的激发束（EB）; 沿着一维扫描线（SL）扫描样品体积（SV）中的激发聚焦（EF）; 将样品体积（SV）中的股线（MS）的末端捕获并沿着平行于扫描线（SL）的一维捕获线（LL）延伸股线（MS）; 对准捕获线（LL）以与扫描线（SL）重合以使扫描激发聚焦（EF）与链（MS）重合; 以及沿着扫描线（SL）记录作为激发焦点（EF）的多个不同扫描位置（X0）的函数的荧光响应（FR）。

    METHODS OF TREATMENT AND DIAGNOSIS FOR COGNITIVE DECLINE AND MEMORY IMPAIRMENT
    94.
    发明申请
    METHODS OF TREATMENT AND DIAGNOSIS FOR COGNITIVE DECLINE AND MEMORY IMPAIRMENT 审中-公开
    治疗和诊断方法对认知失调和记忆障碍的影响

    公开(公告)号：WO2014065669A1

    公开(公告)日：2014-05-01

    申请号：PCT/NL2013/050756

    申请日：2013-10-28

    Applicant: STICHTING VU-VUMC

    Inventor： SMIT, August Benjamin ,  VAN KESTEREN,, Ronald Ernst

    IPC: A61K38/51 ,  A61P25/28

    CPC classification number: A61K38/51

    Abstract: The invention relates to treatments for cognitive decline and/or memory impairment based on reducing the extracellular matrix in the hippocampus. Improved compositions are provided for such treatments. The invention also relates to detection methods for the early diagnosis of cognitive decline and/or memory impairment based on an increase in extracellular matrix in the hippocampus. The treatments and diagnostic methods are especially useful in the field of Alzheimer's disease.

    Abstract translation: 本发明涉及基于减少海马细胞外基质的认知衰退和/或记忆障碍的治疗。 为这些处理提供了改进的组合物。 本发明还涉及基于海马细胞外基质增加的认知衰退和/或记忆障碍的早期诊断的检测方法。 治疗和诊断方法在阿尔茨海默病领域特别有用。

    MICROSCOPIC IMAGING APPARATUS AND METHOD TO DETECT A MICROSCOPIC IMAGE
    95.
    发明申请
    MICROSCOPIC IMAGING APPARATUS AND METHOD TO DETECT A MICROSCOPIC IMAGE 审中-公开
    MICROSCOPIC IMAGAT设备和检测微观图像的方法

    公开(公告)号：WO2014035238A1

    公开(公告)日：2014-03-06

    申请号：PCT/NL2013/050618

    申请日：2013-08-27

    Applicant: STICHTING VU-VUMC

    Inventor： WITTE, Stefan Michiel ,  EIKEMA, Kjeld Sijbrand Eduard

    IPC: G02B21/36 ,  G06F17/14 ,  H01J37/26

    CPC classification number: G02B21/365 ,  G02B21/367 ,  G03F7/70616

    Abstract: The invention relates to amicroscopic imaging apparatus to provide an image of a sample. The apparatus having an illumination system to provide an illumination beam with radiation;and a sensor constructed and arranged to receive: a first image of a first diffraction pattern created by diffraction of the illumination beam on the sample; a second image of a second diffraction pattern created by diffraction of the illumination beam on the sample. The sensor may be connected with a processor running a program to retrieve phase information from the sample from the first and second image received by the sensor. The illumination system may have a first illumination device to provide the illumination beam with radiation of substantially a first wavelength; and a second illumination device to provide the illumination beam with radiation of substantially a second wavelength different than the first wavelength. The sensor may receive a first image of a first diffraction pattern created by diffraction of the illumination beam with radiation of substantially the first wavelength on the sample; and,a second image of a second diffraction pattern created by diffraction of the illumination beam with radiation of substantially the second wavelength on the sample.

    Abstract translation: 本发明涉及提供样品图像的显微镜成像装置。 该装置具有照明系统以提供具有辐射的照明光束;以及传感器，被构造和布置成接收：通过照射光束在样本上的衍射而产生的第一衍射图案的第一图像; 通过照射光束在样品上的衍射而产生的第二衍射图案的第二图像。 传感器可以与运行程序的处理器连接，以从传感器接收的第一和第二图像中检索来自样本的相位信息。 照明系统可以具有第一照明装置，以向照明光束提供基本上第一波长的辐射; 以及第二照明装置，以向照明光束提供不同于第一波长的基本上第二波长的辐射。 传感器可以接收通过照射光束衍射产生的第一衍射图案的第一图像，其中样品具有基本上第一波长的辐射; 以及通过照射光束与样品上具有基本上第二波长的辐射的衍射形成的第二衍射图案的第二图像。

    EBV MARKERS AND SYSTEMIC LUPUS ERYTHEMATOSUS
    96.
    发明申请
    EBV MARKERS AND SYSTEMIC LUPUS ERYTHEMATOSUS 审中-公开

    公开(公告)号：WO2014025254A9

    公开(公告)日：2014-02-13

    申请号：PCT/NL2013/050581

    申请日：2013-08-06

    Applicant: STICHTING VU-VUMC

    Inventor： PEGTEL, Dirk Michiel

    IPC: C12Q1/68 ,  C12Q1/70

    Abstract: The present invention relates to an in vitro method for diagnosis and/or determining severity of Systemic Lupus Erythematosus. The method determines presence and/or quantity of at least one EBV marker, preferably EBV-EBER and/or antibody against EBV antigen, in a sample obtained from a subject. The method may further be used to discriminate between Systemic Lupus Erythematosus, and rheumatoid arthritis.

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