公开(公告)号：FI922875A

公开(公告)日：1992-12-22

申请号：FI922875

申请日：1992-06-18

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  URBACH HANSJOERG ,  RUPPERT DIETER ,  LINZ WOLFGANG

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds of the formula (I) in which X and Y are, for example, N, R , R and R are, for example, hydrogen, A and L are, for example, CH2 or CO, Z is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydroxyl, R is, for example, n is, for example, zero or 1, are active renin-inhibiting compounds which have a high in-vitro and in-vivo activity.

公开(公告)号：HU9202062D0

公开(公告)日：1992-10-28

申请号：HU9202062

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  URBACH HANSJOERG ,  RUPPERT DIETER ,  LINZ WOLFGANG

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds of the formula (I) in which X and Y are, for example, N, R , R and R are, for example, hydrogen, A and L are, for example, CH2 or CO, Z is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydroxyl, R is, for example, n is, for example, zero or 1, are active renin-inhibiting compounds which have a high in-vitro and in-vivo activity.

公开(公告)号：MX9200026A

公开(公告)日：1992-08-01

申请号：MX9200026

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLERT HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOLKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/415 ,  A61K31/425 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D233/12

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：MX9203284A

公开(公告)日：1992-07-31

申请号：MX9203284

申请日：1992-06-24

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  NICKEL WOLF-ULRICH ,  RUPPERT DIETER ,  URBACH HANSJORG

IPC: C07D401/12 ,  C07D401/14 ,  C07C211/00

公开(公告)号：MX9102100A

公开(公告)日：1992-07-08

申请号：MX9102100

申请日：1991-11-15

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  RENNING REINER ,  LINZ WOLFGANG ,  SCHOLKENS BERNWARD ,  URBACH HANSJORG

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/675 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D403/10

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole, pyrrole, pyrazole, triazole or tetrazole type.

公开(公告)号：HUT59599A

公开(公告)日：1992-06-29

申请号：HU358191

申请日：1991-11-15

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  LINZ WOLFGANG ,  SCHOELKENS BERNWARD ,  URBACH HANSJOERG

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/675 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D403/10

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole, pyrrole, pyrazole, triazole or tetrazole type.

公开(公告)号：AU622015B2

公开(公告)日：1992-03-26

申请号：AU5371690

申请日：1990-04-23

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  LINZ WOLFGANG ,  RUPPERT DIETER ,  URBACH HANSJORG ,  WAGNER ADALBERT

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/02 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and W, R , R , R and R are as defined in the description, to processes for the preparation thereof, to the use thereof and to pharmaceutical compositions containing them.

公开(公告)号：NZ234608A

公开(公告)日：1991-12-23

申请号：NZ23460890

申请日：1990-07-23

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER ,  URBACH HANSJORG ,  WAGNER ADALBERT ,  RUPPERT DIETER ,  LINZ WOLFGANG ,  KRAMER WERNER

IPC: C12N9/99 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/445 ,  A61K31/535 ,  A61K38/55 ,  A61P9/12 ,  C07C237/08 ,  C07C237/22 ,  C07D211/26 ,  C07D211/58 ,  C07D233/54 ,  C07D233/64 ,  C07D295/20 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D521/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/078 ,  C07K14/81 ,  C07K5/02 ,  C07D413/12 ,  A61K31/40 ,  A61K31/34 ,  A61K31/195 ,  A61K37/02 ,  A61K37/64 ,  C07D209/12 ,  C07D295/04 ,  C07D333/08

Abstract: The present invention relates to compounds of the formula I in which A, R , R , R and n are defined as indicated in the description, to processes for the preparation thereof, to the use thereof as medicines and to pharmaceutical compositions containing these.

公开(公告)号：PT97195A

公开(公告)日：1991-11-29

申请号：PT9719591

申请日：1991-03-28

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG ,  ENGLERT HEINRICH CHRISTIAN ,  MANIA DIETER

IPC: A61K31/535 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P11/08 ,  A61P17/00 ,  C07D265/20 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D265/00

Abstract: Benzoxazine derivatives of the formula I where R(1) and R(2) equal H, OH, alkoxy, Hal or a multiplicity of other substituents, R(3) equals alkyl or alkanoyl; R(4) equals H, alkyl or alkanoyl, and R(5) equals pyrid(azin)yloxy, pyrimidinyloxy, pyridazinyloxy and other heterocycles and their salts are useful medicaments for the treatment of disorders of the cardiovascular system, asthma, smooth muscle disorders, high blood pressure, cardiac arrhythmias and circulatory disorders of the brain; they are also used for topical application to control hair loss.

公开(公告)号：HU204070B

公开(公告)日：1991-11-28

申请号：HU249990

申请日：1990-04-20

Applicant: HOECHST AG

Inventor： SCHOELKENS BERNWARD ,  LINZ WOLFGANG ,  RUPPERT DIETER ,  URBACH HANSJOERG ,  WAGNER ADALBERT

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, and R , R , R and R are as defined in the description, to processes for the preparation thereof, to their use as medicines and to pharmaceutical agents containing them.