公开(公告)号：CA2219528A1

公开(公告)日：1996-12-12

申请号：CA2219528

申请日：1996-05-28

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K47/24 ,  A61K9/127 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  C07C19/08 ,  A61K9/10 ,  C07C17/42

Abstract: Stabilized compositions comprising, in combination with a gas, a fluorinated amphiphilic compound. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.

公开(公告)号：AU2460195A

公开(公告)日：1996-11-07

申请号：AU2460195

申请日：1995-04-17

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61K49/00 ,  A61B6/00

公开(公告)号：CA2217718A1

公开(公告)日：1996-10-24

申请号：CA2217718

申请日：1995-04-17

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： WU GUANLI ,  UNGER EVAN C

IPC: A61K49/00

Abstract: Novel MRI contrast agents that comprise one or more metal-ion chelates in juxtaposition with one or more free-radical nitroxide compounds in a polymeric or oligomeric molecule. Both the chelate units and the free radical units may, independently, be inside the main chain of the polymer or in a side chain of the linkage portion of the polymer. The number of combined units of chelates and free radicals in the polymer or oligomer is at least two.

公开(公告)号：AU4913896A

公开(公告)日：1996-09-11

申请号：AU4913896

申请日：1996-01-29

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  SHEN DEKANG ,  WU GUANLI

IPC: C12N15/09 ,  A61K9/107 ,  A61K9/127 ,  A61K38/00 ,  A61K47/14 ,  A61K47/16 ,  A61K48/00 ,  A61P37/04 ,  C07C237/10 ,  C07F9/10 ,  C07K14/135 ,  C07K14/50 ,  C12N15/88 ,  C07C69/00 ,  C07C233/00 ,  C12N15/64 ,  A61K9/50

Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.

公开(公告)号：AU3146595A

公开(公告)日：1996-03-29

申请号：AU3146595

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

公开(公告)号：AU7041694A

公开(公告)日：1995-01-03

申请号：AU7041694

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：DE69431753T3

公开(公告)日：2009-07-09

申请号：DE69431753

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：ES2187524T5

公开(公告)日：2009-05-04

申请号：ES94919184

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: METODO Y APARATO PARA PREPARAR LIPOSOMAS LLENADOS CON GAS. ESTOS LIPOSOMAS SON PARTICULARMENTE UTILES, POR EJEMPLO, EN LAS APLICACIONES DE REALIZACION DE IMAGENES ULTRASONICAS Y EN LOS SISTEMAS DE ENVIO DE MEDICAMENTOS TERAPEUTICOS.

公开(公告)号：ES2134214T5

公开(公告)日：2009-03-01

申请号：ES92910021

申请日：1992-03-18

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  C08F20/06 ,  A61K9/10 ,  A61K9/14 ,  A61K49/00 ,  A61K49/04 ,  A61K51/00 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08F122/38 ,  C08F126/10 ,  C08J9/30 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60 ,  G01R33/28

Abstract: SUSPENSIONES ACUOSAS SUSTANCIALMENTE HOMOGENEAS DE MICROESFERAS DE BAJA DENSIDAD SE PRESENTAN COMO MEDIO DE CONTRASTE PARA FORMACION DE IMAGENES DEL TRACTO GASTROINTESTINAL Y OTRAS CAVIDADES DEL CUERPO USANDO TOMOGRAFIA COMPUTERIZADA. EN UNA INCORPORACION, LAS MICROESFERAS DE BAJA DENSIDAD ESTAN RELLENAS DE GAS. CON TOMOGRAFIA COMPUTERIZADA, EL MEDIO DE CONTRASTE SIRVE PARA CAMBIAR LA DENSIDAD RELATIVA DE CIERTAS AREAS DENTRO DEL TRACTO GASTROINTESTINAL Y OTRAS CAVIDADES DEL CUERPO, Y MEJORA LA EFICACIA DEL DIAGNOSTICO GLOBAL DEL METODO DE FORMACION DE IMAGENES.

公开(公告)号：DE69839940D1

公开(公告)日：2008-10-09

申请号：DE69839940

申请日：1998-06-10

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCGREERY THOMAS ,  WU YUNQIU

IPC: A61K49/04 ,  A61B17/20 ,  A61K9/127 ,  A61K41/00 ,  A61K47/00 ,  A61K47/48 ,  A61K49/22 ,  B06B1/00