公开(公告)号：AU2009244897A1

公开(公告)日：2009-11-12

申请号：AU2009244897

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： MEHROTRA MUKUND ,  HUANG WOLIN ,  SONG YONGHONG ,  JIA ZHAOZHONG J ,  XU QING ,  VENKATARAMANI CHANDRASEKAR ,  BAUER SHAWN M ,  PANDEY ANJALI ,  ROSE JACK W ,  KANE BRIAN

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

公开(公告)号：CA2723185A1

公开(公告)日：2009-10-29

申请号：CA2723185

申请日：2009-04-22

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  JIA ZHAOZHONG J ,  MEHROTRA MUKUND ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61K31/52 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07D473/16

Abstract: The present invention is directed to compounds of formula (I)-(II) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

公开(公告)号：AU2009238590A1

公开(公告)日：2009-10-29

申请号：AU2009238590

申请日：2009-04-22

Applicant: PORTOLA PHARM INC

Inventor： MEHROTRA MUKUND ,  PANDEY ANJALI ,  SONG YONGHONG ,  JIA ZHAOZHONG J ,  XU QING ,  BAUER SHAWN M

IPC: C07D239/48 ,  A61K31/506 ,  A61K31/52 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07D473/16

公开(公告)号：MA30775B1

公开(公告)日：2009-10-01

申请号：MA31756

申请日：2009-04-02

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  A61K31/536 ,  A61K31/381 ,  A61K31/517 ,  A61P7/02 ,  C07D239/96 ,  C07D265/22

Abstract: LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS UTILISABLES EN TANT QU'INHIBITEURS DU RÉCEPTEUR PLAQUETTAIRE DE L'ADP DANS LE BUT DE TRAITER UNE THROMBOSE ET DE RÉDUIRE L'ÉVENTUALITÉ ET/OU LA SÉVÉRITÉ D'UN ÉVÉNEMENT ISCHÉMIQUE SECONDAIRE CHEZ UN PATIENT.

公开(公告)号：NO20091331A

公开(公告)日：2009-05-20

申请号：NO20091331

申请日：2009-03-31

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K31/536 ,  C07D239/96

CPC classification number: C07D409/12 ,  C07D239/96 ,  C07D265/22 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

公开(公告)号：CA2664411A1

公开(公告)日：2008-03-27

申请号：CA2664411

申请日：2007-09-20

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  PANDEY ANJALI ,  BAUER SHAWN M

IPC: A61K31/536 ,  A61K31/381 ,  A61K31/517 ,  A61P7/02 ,  C07D239/96 ,  C07D265/22 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds are provided which are useful as platelet ADP receptor inhibito rs, for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.

公开(公告)号：AU2007299723A1

公开(公告)日：2008-03-27

申请号：AU2007299723

申请日：2007-09-20

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  PANDEY ANJALI ,  BAUER SHAWN M

IPC: A61K31/381 ,  A61K31/517 ,  A61K31/536 ,  A61P7/02 ,  C07D239/96 ,  C07D265/22 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds of formula I are provided: wherein Ar1 and Ar2 are substituted aromatic rings and L1 and L2 are independent divalent linking groups. The compounds are useful as platelet ADP receptor inhibitors, for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.

公开(公告)号：CA2856301C

公开(公告)日：2020-10-06

申请号：CA2856301

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D403/12 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/506 ,  C07D239/48 ,  C07D401/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04

Abstract: Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：SG10201601352UA

公开(公告)日：2016-03-30

申请号：SG10201601352U

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

公开(公告)号：PT2323993E

公开(公告)日：2015-10-12

申请号：PT09742982

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： HUANG WOLIN ,  PANDEY ANJALI ,  MEHROTRA MUKUND ,  JIA ZHAOZHONG J ,  VENKATARAMANI CHANDRASEKAR ,  SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  KANE BRIAN ,  ROSE JACK W

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12