-
公开(公告)号：WO2012061428A3
公开(公告)日：2012-10-11
申请号：PCT/US2011058838
申请日：2011-11-01
Applicant: PORTOLA PHARM INC , BAUER SHAWN M , SONG YONGHONG , XU QING , ROSE JACK W , JIA ZHAOZHONG J , KANE BRIAN , HUANG WOLIN , PANDEY ANJALI , MEHROTRA MUKUND
Inventor： BAUER SHAWN M , SONG YONGHONG , XU QING , ROSE JACK W , JIA ZHAOZHONG J , KANE BRIAN , HUANG WOLIN , PANDEY ANJALI , MEHROTRA MUKUND
IPC: C07D213/82 , A61K31/455 , A61P35/00 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04
CPC classification number: C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK kinase activity, methods ofinhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
Abstract translation: 本发明涉及作为JAK激酶抑制剂的式I化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这种化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制JAK激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗多种 至少部分由JAK激酶活性介导的病症，例如不期望的血栓形成和非霍奇金淋巴瘤。
-
公开(公告)号：WO2012061418A3
公开(公告)日：2012-08-02
申请号：PCT/US2011058826
申请日：2011-11-01
Applicant: PORTOLA PHARM INC , JIA ZHAOZHONG J , SONG YONGHONG , XU QING , KANE BRIAN , BAUER SHAWN M , PANDEY ANJALI
Inventor： JIA ZHAOZHONG J , SONG YONGHONG , XU QING , KANE BRIAN , BAUER SHAWN M , PANDEY ANJALI
IPC: C07D213/82 , A61K31/455 , A61P35/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D495/04
CPC classification number: C07C237/42 , C07C237/30 , C07C2601/14 , C07D209/08 , C07D209/40 , C07D213/74 , C07D213/82 , C07D231/12 , C07D231/38 , C07D233/56 , C07D239/48 , C07D249/06 , C07D249/08 , C07D257/04 , C07D261/14 , C07D275/03 , C07D277/42 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.
Abstract translation: 本发明涉及作为Syk激酶抑制剂的式I化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这类化合物的中间体，这种化合物的制备，含有这种化合物的药物组合物，抑制Syk激酶活性的方法，抑制血小板聚集的方法以及预防或治疗一些 至少部分由Syk激酶活性介导的病症，如非霍奇金淋巴瘤。
-
公开(公告)号：WO2013192049A3
公开(公告)日：2014-02-13
申请号：PCT/US2013046006
申请日：2013-06-14
Applicant: PORTOLA PHARM INC
Inventor： JIA ZHAOZHONG J , KANE BRIAN , ROSE JACK , BAUER SHAWN M , SONG YONGHONG , XU QING , PANDEY ANJALI
IPC: A01N43/64 , A01N43/707 , A61K31/53
CPC classification number: C07D253/075 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
Abstract translation: 提供用于抑制Syk激酶的三嗪化合物，用于制备这种化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法，以及至少部分地通过Syk激酶活性介导的病症的治疗方法。
-
公开(公告)号：WO2013192046A2
公开(公告)日：2013-12-27
申请号：PCT/US2013045987
申请日：2013-06-14
Applicant: PORTOLA PHARM INC
Inventor： SONG YONGHONG , XU QING , SRAN ARVINDER , BAUER SHAWN M , JIA ZHAOZHONG J , KANE BRIAN , PANDEY ANJALI
IPC: A61K31/4709 , C07D401/02
CPC classification number: C07D417/12 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: Provided are picolinamide compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
Abstract translation: 提供了用于抑制Syk激酶的吡啶酰胺化合物，用于制备这种化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法，以及用于至少部分地通过Syk激酶活性介导的病症的治疗方法。
-
公开(公告)号：EP2782580A4
公开(公告)日：2015-10-07
申请号：EP12851734
申请日：2012-11-23
Applicant: PORTOLA PHARM INC
Inventor： JIA ZHAOZHONG J , KANE BRIAN , XU QING , BAUER SHAWN M , SONG YONGHONG , PANDEY ANJALI , DICK RYAN
IPC: A61K31/506 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07H13/12
CPC classification number: C07H15/26 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07H13/12
-
Patent Agency Ranking
公开(公告)号：EP2782579A4
公开(公告)日：2015-08-26
申请号：EP12852197
申请日：2012-11-23
Applicant: PORTOLA PHARM INC
Inventor： SONG YONGHONG , XU QING , JIA ZHAOZHONG J , KANE BRIAN , BAUER SHAWN M , PANDEY ANJALI
IPC: C07D403/12 , A61K31/4965 , A61P7/00 , A61P9/00 , A61P31/00 , A61P33/00 , A61P37/00 , C07D401/12 , C07D417/12
CPC classification number: C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
Abstract: Provided are substituted pyrazine-2-carboxamide compounds of Formula I: useful for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
Abstract translation: 提供式I的取代吡嗪-2-甲酰胺化合物：可用于抑制Syk激酶，用于制备此类化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法和用于治疗在 至少部分由Syk激酶活性。
-
公开(公告)号：EP2863905A4
公开(公告)日：2015-12-16
申请号：EP13807089
申请日：2013-06-14
Applicant: PORTOLA PHARM INC
Inventor： SONG YONGHONG , XU QING , SRAN ARVINDER , BAUER SHAWN M , JIA ZHAOZHONG J , KANE BRIAN , PANDEY ANJALI
IPC: C07D401/12 , A61K31/4439 , A61K31/444 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
CPC classification number: C07D417/12 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
-
8.发明公开
公开(公告)号：EP2863748A4
公开(公告)日：2015-12-09
申请号：EP13807456
申请日：2013-06-14
Applicant: PORTOLA PHARM INC
Inventor： JIA ZHAOZHONG J , KANE BRIAN , ROSE JACK , BAUER SHAWN M , SONG YONGHONG , XU QING , PANDEY ANJALI
IPC: A01N43/64 , A01N43/707 , A61K31/53 , C07D253/075 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
CPC classification number: C07D253/075 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
Abstract translation: 提供用于抑制Syk激酶的三嗪化合物，用于制备这种化合物的中间体，其制备方法，其药物组合物，抑制Syk激酶活性的方法，以及至少部分地通过Syk激酶活性介导的病症的治疗方法。
-
公开(公告)号：CA2728893C
公开(公告)日：2017-03-14
申请号：CA2728893
申请日：2009-04-16
Applicant: PORTOLA PHARM INC
Inventor： VENKATARAMANI CHANDRASEKAR , HUANG WOLIN , MEHROTRA MUKUND , SONG YONGHONG , XU QING , BAUER SHAWN M , PANDEY ANJALI , KANE BRIAN , JIA ZHAOZHONG J , ROSE JACK W
IPC: C07D239/48 , A61K31/506 , A61P9/00 , A61P35/00 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods ofinhibilion the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as cardiovascular disease, inflammatory disease and autoimune disease and cell proliferative disorder. Formula (I) Y1 is selected from the group consisting of: (a) and (b); Z is O or S; D1 is selected from the group consisting of: (a) phenyl substituted with a group, R5 (b) naphthyl (c) C3-8cycloalkyl (d) heteroaryl (e) heterocyclyl
-
公开(公告)号：AU2011323484B2
公开(公告)日：2016-10-06
申请号：AU2011323484
申请日：2011-11-01
Applicant: PORTOLA PHARM INC
Inventor： JIA ZHAOZHONG J , SONG YONGHONG , XU QING , KANE BRIAN , BAUER SHAWN M , PANDEY ANJALI
IPC: C07D213/82 , A61K31/455 , A61P35/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D495/04
Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.
-
-
-
-
-
-
-
-
-
Search Results
61
records
(took 0.022 seconds)
